In a recent communication1 was presented the pharmacologic action of the so-called female remedies on strips of the excised uterus of the guinea-pig. Many of them depressed the activity of the strips, but it was suggested that this effect might have been nothing more than an action on nonstriped muscle in general and that it was in no sense specific to the uterus muscle. To investigate this question experiments have been made on other forms of smooth muscle, namely, strips of intestine of the rabbit and the arteries of the kidneys of dogs. The results of this work show that these drugs, when active, do not act specifically on the uterus.
The experiments on the intestine were made in a similar manner to the experiments on the excised uterus of the guinea-pigs ; a segment of the small intestine of the rabbit, about 2 or 3 cm. long, was attached