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Article
September 1917

THE ETIOLOGIC AGENT OF RAT BITE DISEASE: PRELIMINARY REPORT

Arch Intern Med (Chic). 1917;XX(3):317-328. doi:10.1001/archinte.1917.00090030002001
Abstract

That there exists a particular form of disease due to rat bite has been long recognized in Japan, where incidents of rat bite have been more frequent than in certain other countries. Although some cases have been reported by American, as well as French, German, British and Spanish physicians, yet the establishment of a definite disease as a result of rat bite has been chiefly the work of Japanese observers. Miyake1 and Crohn2 have given exhaustive reviews of the subject, together with their own case reports.

As to the etiologic agent, Ogata3 thought it to be an organism belonging to the Sporozoa, while in German cases, the association of a streptothrix was reported by Schottmüller.4 In a recent article, Blake5 reports having obtained a pure culture of Streptothrix muris ratti of Schottmüller from a case of rat bite, by means of which he was able to reproduce in some rats

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