Following the administration of full therapeutic doses of salicylate there is a rather marked diminution in urine output, reaching its greatest depression about ten to twenty hours after the symptoms of toxicity appear and persisting for about forty to seventy hours after the administration of the drug. The output of urine reaches its previous level roughly about the time excretion of salicyl is completed.
Two possible explanations are suggested for this: (1) sweating; (2) retention of water, that is, edema; the important factors to be considered in retention are (a) tissues, and (b) kidney.
It is the object of this communication to report certain facts bearing on these causes. The work was conducted in a quantitative way and on persons some of whom were practically normal, others convalescent from various disorders. The following procedures were carried out before and after the administration of the salicylate, and throughout the experiment, which
HANZLIK PJ, SCOTT RW, REYCRAFT JL. THE SALICYLATES: VIII. SALICYL EDEMA. Arch Intern Med (Chic). 1917;XX(3):329–340. doi:10.1001/archinte.1917.00090030014002
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