What we now call angioneurotic edema was first adequately described by Quincke,1 in 1882, as "acute circumscribed edema of the skin." He looked on it as a vascular neurosis and attempted to separate it clinically from all other forms of local edema as a distinct disease. But while to Quincke belongs all the credit of having first presented the subject with the detail and interpretation necessary to its general recognition, he was not the first to observe the condition so carefully as to recognize its individual character. This had been done ten years earlier by Milton,2 who recorded his observations in 1876 under the title, "On Giant Urticaria," pointing out clearly that the cases were of a new kind to him and were distinctly different from the severest forms of urticaria as previously described and commonly understood. Had he dignified with a new name the new condition he observed so
CROWDER JR, CROWDER TR. FIVE GENERATIONS OF ANGIONEUROTIC EDEMA. Arch Intern Med (Chic). 1917;XX(6):840–852. doi:10.1001/archinte.1917.00090060014002
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