The term "lipodystrophia progressiva" was first applied by Arthur Simons to a syndrome as described by him,1 in 1911.
This condition is rather uncommon. Up to the present about twenty-four cases have been reported and the only case in American literature I have been able to find has been published by Herrman.2 The most recent and comprehensive review of this subject is by F. Parks Webber,3 who has collected all the reported cases and clearly discusses this condition, its probable causes, its course, the outlook in the various cases, and has reviewed them up to the time of his article and also several cases with which he was familiar but which had not yet appeared in the literature.
Lipodystrophia progressiva is a term applied by Simons to a syndrome beginning most frequently between the fifth and twelfth year, and chiefly affecting females. In this condition, there occurs a gradual, progressive