In their report of a randomized trial of nicotine lozenges, Shiffman et al1 comment that the study demonstrated the efficacy and safety of the lozenges for smoking cessation. However, Penman and I have previously cautioned against generalizing the results of nicotine replacement therapy (NRT) efficacy trials conducted under relatively ideal conditions to more "real-world" conditions.2
Walsh RA. Nicotine Lozenge Trial: A "Real-World" Perspective. Arch Intern Med. 2002;162(22):2632. doi:
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