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Editor's Correspondence
December 9/23, 2002

Cyclooxygenase-2 Inhibitors and Myocardial Infarction

Arch Intern Med. 2002;162(22):2639. doi:

The findings from 3 case-control studies in a recent issue of the ARCHIVES1-3 do not eliminate the possibility that cyclooxygenase (COX)-2 inhibitors increase the risk of myocardial infarction (MI) and other thrombotic cardiovascular events by altering the balance between prostacyclin and thromboxane.4,5 The studies suggest that naproxen may modestly decrease the risk of MI.

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