The trial by Case et al1 adds to the limited evidence that is available on the effectiveness of acetaminophen in OA. To our knowledge, this study is only the second randomized controlled trial comparing acetaminophen with placebo and appears to contradict the results of a previous double-blind crossover trial in 25 patients conducted in the early 1980s.2 More recent trials compared traditional nonsteroidal anti-inflammatory drugs with acetaminophen, but did not include a placebo arm.3
Zwahlen M, Jüni P, Egger M. What Now About Acetaminophen? Arch Intern Med. 2003;163(15):1862–1863. doi:10.1001/archinte.163.15.1862-a
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