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January 2021, Vol 181, No. 1, Pages 4-144

Perspective

Watch Your Language!—Misusage and Neologisms in Clinical Communication

Abstract Full Text
JAMA Intern Med. 2021;181(1):5-6. doi:10.1001/jamainternmed.2020.5679

This essay discusses the prevalence of medical jargon and how clinicians can consciously avoid jargon and work to improve communication with patients and their families.

No Bad Blood—Surviving Severe Anemia Without Transfusion

Abstract Full Text
JAMA Intern Med. 2021;181(1):7-8. doi:10.1001/jamainternmed.2020.6560

This article describes the care of a Jehovah’s Witness patient to highlight the importance of patient-centered care and shared decision-making when treating underrepresented populations at risk for stigmatization by the medical community.

Original Investigation

Assessment of Variation in State Regulation of Generic Drug and Interchangeable Biologic Substitutions

Abstract Full Text
JAMA Intern Med. 2021;181(1):16-22. doi:10.1001/jamainternmed.2020.3588

This cohort study examines the varying policies on substitution of generic drugs for brand-name products throughout the US.

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Intern Med. 2021;181(1):24-31. doi:10.1001/jamainternmed.2020.6615

This randomized clinical trial evaluates the effect of early tocilizumab administration vs standard therapy in preventing clinical worsening in patients hospitalized with COVID-19.

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):32-40. doi:10.1001/jamainternmed.2020.6820

This randomized clinical trial examines the effects of tocilizumab vs usual care in patients hospitalized with COVID-19 and moderate-to-severe pneumonia.

Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

Abstract Full Text
free access
JAMA Intern Med. 2021;181(1):41-51. doi:10.1001/jamainternmed.2020.6252

This cohort study assesses mortality rates among patients with COVID-19 admitted to intensive care who were treated with tocilizumab.

Assessment of Availability, Clinical Testing, and US Food and Drug Administration Review of Biosimilar Biologic Products

Abstract Full Text
JAMA Intern Med. 2021;181(1):52-60. doi:10.1001/jamainternmed.2020.3997

This study examines the US Food and Drug Administration’s approval process for biosimilar biologic products by evaluating the site and facility inspections, animal and human studies, and comparative efficacy trials conducted to support the applications.

Nutritional Analysis of Foods and Beverages Depicted in Top-Grossing US Movies, 1994-2018

Abstract Full Text
JAMA Intern Med. 2021;181(1):61-70. doi:10.1001/jamainternmed.2020.5421

This qualitative study compares nutritional content depicted in the 250 top-grossing US movies from 1994 to 2018 with established nutrition rating systems, dietary recommendations, and US individuals’ actual consumption.

Effect of Recombinant Human Granulocyte Colony–Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia: A Randomized Clinical Trial

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):71-78. doi:10.1001/jamainternmed.2020.5503

This randomized clinical trial examines the effect of recombinant human granulocyte colony-stimulating factor on peripheral blood leukocyte and lymphocyte cell counts and clinical improvement in Chinese patients with COVID-19.

Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial

Abstract Full Text
JAMA Intern Med. 2021;181(1):81-92. doi:10.1001/jamainternmed.2020.5519

This randomized clinical trial compares the risk of overcorrection with use of rapid intermittent bolus and slow continuous infusion with hypertonic saline in patients with symptomatic severe hyponatremia.

Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(1):93-102. doi:10.1001/jamainternmed.2020.5640

This cohort study describes the ventilatory support provided within 30 days of death in older adults with chronic obstructive pulmonary disease, congestive heart failure, cancer, or dementia.

Association of Therapies With Reduced Pain and Improved Quality of Life in Patients With Fibromyalgia: A Systematic Review and Meta-analysis

Abstract Full Text
has active quiz
JAMA Intern Med. 2021;181(1):104-112. doi:10.1001/jamainternmed.2020.5651

This systematic review and meta-analysis investigates the effectiveness of therapies for reducing pain and improving quality of life in people with fibromyalgia.

Editorial

Severe COVID-19 Infections—Knowledge Gained and Remaining Questions

Abstract Full Text
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JAMA Intern Med. 2021;181(1):9-11. doi:10.1001/jamainternmed.2020.6047

Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia

Abstract Full Text
free access
JAMA Intern Med. 2021;181(1):12-15. doi:10.1001/jamainternmed.2020.6557
Invited Commentary

Addressing the Cost of Biologic and Specialty Drugs

Abstract Full Text
JAMA Intern Med. 2021;181(1):22-23. doi:10.1001/jamainternmed.2020.3593

Immune Stimulation With Recombinant Human Granulocyte Colony–Stimulating Factor for Coronavirus Disease 2019 (COVID-19)—Beware of Blind Spots

Abstract Full Text
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JAMA Intern Med. 2021;181(1):78-80. doi:10.1001/jamainternmed.2020.5536

Noninvasive Ventilation in Seriously Ill Older Adults at the End of Life—The Evidence Remains Elusive

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(1):102-103. doi:10.1001/jamainternmed.2020.5648
Teachable Moment

Addressing Spiritual and Religious Needs in Advanced Illness: A Teachable Moment

Abstract Full Text
has active quiz
JAMA Intern Med. 2021;181(1):115-116. doi:10.1001/jamainternmed.2020.6564

This Teachable Moment discusses the benefits of addressing patients’ spiritual and religious needs in patient care, particularly at the end of life.

Research Letter

COVID-19: Beyond Tomorrow

Implications of Early Health Care Spending Reductions for Expected Spending as the COVID-19 Pandemic Evolves

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):118-120. doi:10.1001/jamainternmed.2020.5333

This cohort study examines how early spending changes vary by incidence of coronavirus disease 2019 and how implementation of policies to limit transmission affect health care spending as the pandemic evolves.

Risk of Severe COVID-19 Among Workers and Their Household Members

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):120-122. doi:10.1001/jamainternmed.2020.6249

This survey study uses prepandemic data to estimate how many adults at increased risk of severe COVID-19 held essential jobs and could not work at home or lived in households with such workers.

Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):122-124. doi:10.1001/jamainternmed.2020.6278

This case-control study examines the association of COVID-19 with the respiratory muscles in Dutch critically ill patients.

Diversity and Representation of Physicians During the COVID-19 News Cycle

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):124-127. doi:10.1001/jamainternmed.2020.6285

This cross-sectional study investigates the diversity of speakers who discussed COVID-19 and other content on cable news programs.

Outcomes of Universal COVID-19 Testing Following Detection of Incident Cases in 11 Long-term Care Facilities

Abstract Full Text
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JAMA Intern Med. 2021;181(1):127-129. doi:10.1001/jamainternmed.2020.3738

This cross-sectional study evaluates the outcomes of universal COVID-19 testing following discovery of incident cases in 11 long-term care facilities in the US.

Association of Neighborhood Characteristics and Travel Patterns With Fatal Drug Overdoses

Abstract Full Text
JAMA Intern Med. 2021;181(1):129-131. doi:10.1001/jamainternmed.2020.3823

This cross-sectional study examines the travel patterns from home residences to locations of fatal drug overdoses in Cook County, Illinois, from August 1, 2014, to December 31, 2018.

Assessment of COVID-19 Hospitalizations by Race/Ethnicity in 12 States

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(1):131-134. doi:10.1001/jamainternmed.2020.3857

This cohort study uses data from a COVID-19 tracking project to assess the prevalence of COVID-19 infection by race/ethnicity in 12 US states.

Disparities in Secondhand Smoke Exposure in the United States: National Health and Nutrition Examination Survey 2011-2018

Abstract Full Text
open access
JAMA Intern Med. 2021;181(1):134-137. doi:10.1001/jamainternmed.2020.3975

This cross-sectional study examines National Health and Nutrition Examination Survey data to assess the prevalence of secondhand smoke exposure in nonsmokers in the US population 3 years and older.

Challenges in Clinical Electrocardiography

Syncope Due to Complete Heart Block—A Ticking Time Bomb

Abstract Full Text
JAMA Intern Med. 2021;181(1):113-114. doi:10.1001/jamainternmed.2020.5660

This case report describes man in his 20s with no documented medical history presented to the emergency department after an unwitnessed syncopal event who was subsequently diagnosed with Lyme disease.

Comment & Response

The Assessment of Different Diets and Mortality Fails to Address Unmeasured Confounding

Abstract Full Text
JAMA Intern Med. 2021;181(1):137-138. doi:10.1001/jamainternmed.2020.1391

The Assessment of Different Diets and Mortality Fails to Address Unmeasured Confounding—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(1):138-139. doi:10.1001/jamainternmed.2020.1388

The Uncertain Role of Corticosteroids in the Treatment of COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(1):139-140. doi:10.1001/jamainternmed.2020.2438

The Uncertain Role of Corticosteroids in the Treatment of COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(1):140. doi:10.1001/jamainternmed.2020.2444

The Uncertain Role of Corticosteroids in the Treatment of COVID-19—Reply

Abstract Full Text
free access
JAMA Intern Med. 2021;181(1):140-141. doi:10.1001/jamainternmed.2020.2435

Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin

Abstract Full Text
JAMA Intern Med. 2021;181(1):141. doi:10.1001/jamainternmed.2020.5050

Health Care Policy and Law

Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(1):141-142. doi:10.1001/jamainternmed.2020.5047

Anticoagulation Therapy and Fall Reduction

Abstract Full Text
JAMA Intern Med. 2021;181(1):142. doi:10.1001/jamainternmed.2020.5418

Complexities and Outcomes of Advance Care Planning

Abstract Full Text
JAMA Intern Med. 2021;181(1):142-143. doi:10.1001/jamainternmed.2020.5539

Prediction Models for COVID-19 Need Further Improvements

Abstract Full Text
free access
JAMA Intern Med. 2021;181(1):143-144. doi:10.1001/jamainternmed.2020.5740

Corrections to Assessment of Variation in State Regulation of Generic Drug and Interchangeable Biologic Substitutions

Abstract Full Text
JAMA Intern Med. 2021;181(1):144. doi:10.1001/jamainternmed.2020.6554
Correction

Coding Errors Resulting in Some US State Misclassifications

Abstract Full Text
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JAMA Intern Med. 2021;181(1):144. doi:10.1001/jamainternmed.2020.7344

Error in Author Order of the Byline

Abstract Full Text
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JAMA Intern Med. 2021;181(1):144. doi:10.1001/jamainternmed.2020.7772

Errors in Group Information Supplement and End Matter

Abstract Full Text
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JAMA Intern Med. 2021;181(1):144. doi:10.1001/jamainternmed.2020.7810
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
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JAMA Intern Med. 2021;181(1):4. doi:10.1001/jamainternmed.2020.5243
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