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May 2021, Vol 181, No. 5, Pages 576-732

Viewpoint

Health Care Policy and Law

Placebo—The Unknown Variable in a Controlled Trial

Abstract Full Text
JAMA Intern Med. 2021;181(5):577-578. doi:10.1001/jamainternmed.2020.8670

This Viewpoint discusses how improper matching of placebos to experimental drugs in controlled trials can lead to underreporting of harms, confounding, and misleading trial outcomes.

Declining Accuracy of the Traditional Diamond-Forrester Estimates of Pretest Probability of Coronary Artery Disease: Time for New Methods

Abstract Full Text
JAMA Intern Med. 2021;181(5):579-580. doi:10.1001/jamainternmed.2021.0171

This Viewpoint summarizes the evidence for a decline in the accuracy of Diamond-Forrester pretest probability estimates, indicates which estimation method is most reliable, and explains why these estimates are clinically useful.

Perspective

Outpatient Dietary Management of Electrolyte Disorders During COVID-19: Food as Medicine

Abstract Full Text
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JAMA Intern Med. 2021;181(5):581-582. doi:10.1001/jamainternmed.2020.8897

This essay discusses the use of food substitutes rather than medications as a treatment for electrolyte repletion.

Original Investigation

Association of Medicaid Expansion With Quality in Safety-Net Hospitals

Abstract Full Text
JAMA Intern Med. 2021;181(5):590-597. doi:10.1001/jamainternmed.2020.9142

This cohort study compares quality measures in safety-net hospitals between states with Medicaid expansion vs nonexpansion following implementation of the Affordable Care Act.

Severe Hypoglycemia Risk With Long-Acting Insulin Analogs vs Neutral Protamine Hagedorn Insulin

Abstract Full Text
JAMA Intern Med. 2021;181(5):598-607. doi:10.1001/jamainternmed.2020.9176

This cohort study compares the associations of long-acting insulin analogs and NPH insulin with the risk of severe hypoglycemia in older patients with type 2 diabetes.

Effect of a Multifaceted Clinical Pharmacist Intervention on Medication Safety After Hospitalization in Persons Prescribed High-risk Medications: A Randomized Clinical Trial

Abstract Full Text
JAMA Intern Med. 2021;181(5):610-618. doi:10.1001/jamainternmed.2020.9285

This randomized clinical trial examines the effect of a multifaceted clinical pharmacist intervention on medication safety for patients who are discharged from the hospital and prescribed medications within 1 or more high-risk drug classes.

Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial

Abstract Full Text
JAMA Intern Med. 2021;181(5):620-630. doi:10.1001/jamainternmed.2021.0005

This randomized clinical trial compares the efficacy of standard vs sham osteopathic manipulative treatment for reducing activity limitations at 3 months in patients with nonspecific subacute or chronic low back pain.

Associations of Fish Consumption With Risk of Cardiovascular Disease and Mortality Among Individuals With or Without Vascular Disease From 58 Countries

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(5):631-649. doi:10.1001/jamainternmed.2021.0036

This analysis pools data from 4 large cohort studies conducted in 58 countries to assess whether associations of fish consumption with risk of cardiovascular disease or mortality differ between individuals with and individuals without vascular disease.

Deficits in Advance Care Planning for Patients With Decompensated Cirrhosis at Liver Transplant Centers

Abstract Full Text
JAMA Intern Med. 2021;181(5):652-660. doi:10.1001/jamainternmed.2021.0152

This qualitative study describes the end-of-life care attitudes, beliefs, practices, and discussions reported by patients with decompensated cirrhosis and the clinical team at liver transplant centers.

Health Care Reform

Unmet Need for Equipment to Help With Bathing and Toileting Among Older US Adults

Abstract Full Text
JAMA Intern Med. 2021;181(5):662-670. doi:10.1001/jamainternmed.2021.0204

This national cohort study estimates the lack of equipment to help with bathing and toileting among US adults 65 years or older and describes factors associated with underuse.

Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection

Abstract Full Text
open access has active quiz
JAMA Intern Med. 2021;181(5):672-679. doi:10.1001/jamainternmed.2021.0366

This cohort study evaluates evidence of SARS-CoV-2 infection based on diagnostic nucleic acid amplification test among patients who tested positive versus negative for antibodies.

Editorial

JAMA Internal Medicine—The Year in Review, 2020

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JAMA Intern Med. 2021;181(5):583-584. doi:10.1001/jamainternmed.2021.0351

Screening for Asymptomatic Carotid Artery Stenosis in Adult Patients: Unclear Benefit but Downstream Risks

Abstract Full Text
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JAMA Intern Med. 2021;181(5):585-587. doi:10.1001/jamainternmed.2021.0029

Less Is More

Recommendations From Breast Cancer Centers for Frequent Screening Mammography in Younger Women May Do More Harm Than Good

Abstract Full Text
JAMA Intern Med. 2021;181(5):588-589. doi:10.1001/jamainternmed.2021.0161
Invited Commentary

Less Is More

The Cost and Safety of Insulin in Older Adults

Abstract Full Text
JAMA Intern Med. 2021;181(5):608-609. doi:10.1001/jamainternmed.2020.9185

Adverse Drug Events After Hospitalization—Are We Missing the Mark?

Abstract Full Text
JAMA Intern Med. 2021;181(5):618-619. doi:10.1001/jamainternmed.2020.9282

Fish, Cardiovascular Disease, and Mortality—What Is the Global Evidence?

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(5):649-651. doi:10.1001/jamainternmed.2021.0045

Advance Care Planning in Liver Transplant—Preparing for Both Life and Death

Abstract Full Text
JAMA Intern Med. 2021;181(5):660-661. doi:10.1001/jamainternmed.2021.0149

Addressing Unmet Adaptive Equipment Needs Through Primary Care

Abstract Full Text
JAMA Intern Med. 2021;181(5):670-671. doi:10.1001/jamainternmed.2021.0398

The Health Consequences of Restrictive Abortion Laws

Abstract Full Text
JAMA Intern Med. 2021;181(5):713-714. doi:10.1001/jamainternmed.2020.9279
Editor's Note

How to Advise Persons Who Are Antibody Positive for SARS-CoV-2 About Future Infection Risk

Abstract Full Text
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JAMA Intern Med. 2021;181(5):679. doi:10.1001/jamainternmed.2021.0374

Challenges in Testing for SARS-CoV-2 Among Patients Who Recovered From COVID-19

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(5):704-705. doi:10.1001/jamainternmed.2020.7575
Special Communication

Clinical Trials Without Clinical Sites

Abstract Full Text
JAMA Intern Med. 2021;181(5):680-684. doi:10.1001/jamainternmed.2020.9223

This special communication reviews the benefits and limitations of conducting clinical trials without clinical sites.

Teachable Moment

Insulin Pump Treatment for the Hospitalized Patient

Abstract Full Text
JAMA Intern Med. 2021;181(5):685-686. doi:10.1001/jamainternmed.2021.0106

This Teachable Moment describes the necessity for clinician familiarity with insulin pumps because of their increased use among patients with type 1 diabetes.

Health Care Reform

Avoiding a Crisis With High-Deductible Insurance Plans: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2021;181(5):687-688. doi:10.1001/jamainternmed.2021.0109

This Teachable Moment explores the issues associated with high-deductible insurance plans when a patient delayed diagnosis and treatment because of financial concerns.

Missed Opportunity for Fall Prevention: A Teachable Moment

Abstract Full Text
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JAMA Intern Med. 2021;181(5):689-690. doi:10.1001/jamainternmed.2021.0221

This Teachable Moment discusses the experience of a 76-year-old patient with a fractured hip and a history of repeated falls and considers missed opportunities to recommend fall prevention interventions.

Research Letter

Health Care Policy and Law

Payment for Dialysis Services in the Individual Market

Abstract Full Text
JAMA Intern Med. 2021;181(5):698-699. doi:10.1001/jamainternmed.2020.7372

This cross-sectional study examines the prevalence and spending of patients with end-stage kidney disease in the individual market.

Unemployment Insurance, Health-Related Social Needs, Health Care Access, and Mental Health During the COVID-19 Pandemic

Abstract Full Text
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JAMA Intern Med. 2021;181(5):699-702. doi:10.1001/jamainternmed.2020.7048

This cross-sectional study assesses whether receiving unemployment insurance is associated with lower health-related social needs, better health care access, and better mental health during the COVID-19 pandemic.

Assessment of SARS-CoV-2 RNA Test Results Among Patients Who Recovered From COVID-19 With Prior Negative Results

Abstract Full Text
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JAMA Intern Med. 2021;181(5):702-704. doi:10.1001/jamainternmed.2020.7570

This study examines positive real-time polymerase chain reaction nasal-oropharyngeal swab results from patients who recovered from COVID-19 with prior negative results.

Excess Mortality in California During the Coronavirus Disease 2019 Pandemic, March to August 2020

Abstract Full Text
open access has active quiz
JAMA Intern Med. 2021;181(5):705-707. doi:10.1001/jamainternmed.2020.7578

This time-series analysis examines the excess number of deaths across population subgroups in California during the COVID-19 pandemic.

Association of Medical Stimulants With Mortality in the US From 2010 to 2017

Abstract Full Text
JAMA Intern Med. 2021;181(5):707-709. doi:10.1001/jamainternmed.2020.7850

This cross-sectional study examines the association of medical stimulants with mortality in the US from 2010 to 2017.

Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry

Abstract Full Text
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JAMA Intern Med. 2021;181(5):709-711. doi:10.1001/jamainternmed.2020.8360

This cohort study assesses the association of cumulative smoking exposure, as measured by pack-years, with outcomes of patients with coronavirus disease 2019.

State Legislation Related to Abortion Services, January 2017 to November 2020

Abstract Full Text
JAMA Intern Med. 2021;181(5):711-713. doi:10.1001/jamainternmed.2020.8781

This survey study examines trends in abortion policies among states by analyzing legislation enacted between January 2017 and November 2020.

Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(5):714-717. doi:10.1001/jamainternmed.2020.9241

This cohort study compares the clinical characteristics and outcomes of hospitalized women who gave birth with and without coronavirus disease 2019.

Assessment of Screening Mammography Recommendations by Breast Cancer Centers in the US

Abstract Full Text
JAMA Intern Med. 2021;181(5):717-719. doi:10.1001/jamainternmed.2021.0157

This cross-sectional study examines current screening mammography recommendations regarding starting age and screening interval among breast cancer centers in the US.

Challenges in Clinical Electrocardiography

Progressive PR Prolongation in an Asymptomatic Man

Abstract Full Text
JAMA Intern Med. 2021;181(5):691-692. doi:10.1001/jamainternmed.2020.9216

This case report presents the electrocardiographic findings of an asymptomatic older adult with a heart rate of 54 beats/min who was referred for a cardiologic evaluation.

Sustained Postural Wide QRS Complex Tachycardia in an Intensive Care Unit Patient

Abstract Full Text
JAMA Intern Med. 2021;181(5):693-694. doi:10.1001/jamainternmed.2021.0001

This case report describes a patient in their 30s with obesity and a history of alcohol use who presented with recurrent arrhythmia on telemetry during an admission for acute pancreatitis.

ST Segment Elevation in a Patient With Myocardial Metastases: What Is Up With That?

Abstract Full Text
JAMA Intern Med. 2021;181(5):695-696. doi:10.1001/jamainternmed.2021.0101

This case report describes the electrocardiographic findings of a man in his 70s with a history of multiple prior ST-segment elevation myocardial infarctions and squamous cell carcinoma of the lung.

JAMA Internal Medicine Patient Page

Should I Get a Coronary CT Scan?

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JAMA Intern Med. 2021;181(5):732. doi:10.1001/jamainternmed.2021.0168

This JAMA Patient Page describes the 2 different types of coronary computed tomography scans, as well as their benefits and risks.

Comment & Response

Community Outbreak Investigation of SARS-CoV-2 Transmission Among Bus Riders in Eastern China—More Detailed Studies Are Needed

Abstract Full Text
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JAMA Intern Med. 2021;181(5):719-720. doi:10.1001/jamainternmed.2020.8567

Community Outbreak Investigation of SARS-CoV-2 Transmission Among Bus Riders in Eastern China—More Detailed Studies Are Needed—Reply

Abstract Full Text
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JAMA Intern Med. 2021;181(5):720-721. doi:10.1001/jamainternmed.2020.8570

Physicians’ Electrocardiogram Interpretations

Abstract Full Text
JAMA Intern Med. 2021;181(5):721. doi:10.1001/jamainternmed.2020.8598

Physicians’ Electrocardiogram Interpretations

Abstract Full Text
JAMA Intern Med. 2021;181(5):721-722. doi:10.1001/jamainternmed.2020.8605

Physicians’ Electrocardiogram Interpretations—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(5):722-723. doi:10.1001/jamainternmed.2020.8652

Second-degree Atrioventricular Block

Abstract Full Text
JAMA Intern Med. 2021;181(5):723-724. doi:10.1001/jamainternmed.2020.8601

Second-Degree Atrioventricular Block—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(5):724. doi:10.1001/jamainternmed.2020.8595

Timing of Dialysis Initiation and End-stage Kidney Disease Incidence

Abstract Full Text
JAMA Intern Med. 2021;181(5):724-725. doi:10.1001/jamainternmed.2020.8809

Timing of Dialysis Initiation and End-Stage Kidney Disease Incidence—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(5):725-726. doi:10.1001/jamainternmed.2020.8806

Preventing Opioid-Induced Constipation

Abstract Full Text
JAMA Intern Med. 2021;181(5):726. doi:10.1001/jamainternmed.2020.8894

Preventing Opioid-Induced Constipation—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(5):726-727. doi:10.1001/jamainternmed.2020.8886
Correction

Updated Information About Index Patient in Study of SARS-CoV-2 Transmission Among Bus Riders in Eastern China

Abstract Full Text
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JAMA Intern Med. 2021;181(5):727. doi:10.1001/jamainternmed.2020.8608

Error in the Results Section

Abstract Full Text
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JAMA Intern Med. 2021;181(5):727. doi:10.1001/jamainternmed.2020.9154

Error in Results Data

Abstract Full Text
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JAMA Intern Med. 2021;181(5):727. doi:10.1001/jamainternmed.2021.0340

Error in Figure

Abstract Full Text
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JAMA Intern Med. 2021;181(5):727. doi:10.1001/jamainternmed.2021.1353

Error in Author Affiliation

Abstract Full Text
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JAMA Intern Med. 2021;181(5):727. doi:10.1001/jamainternmed.2021.1536

Error in Figure Value

Abstract Full Text
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JAMA Intern Med. 2021;181(5):727. doi:10.1001/jamainternmed.2021.2050
Peer Reviewers List

JAMA Internal Medicine Peer Reviewers in 2020

Abstract Full Text
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JAMA Intern Med. 2021;181(5):e210185. doi:10.1001/jamainternmed.2021.0185
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
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JAMA Intern Med. 2021;181(5):576. doi:10.1001/jamainternmed.2020.5267
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