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April 2021, Vol 181, No. 4, Pages 420-570

Viewpoint

Challenges of a Supplemental Private Option Under National Health Insurance—Observations From Australia

Abstract Full Text
JAMA Intern Med. 2021;181(4):421-422. doi:10.1001/jamainternmed.2020.8435

This Viewpoint describes the role of private hospital insurance in Australia, a country with universal government-sponsored insurance.

Authorized Generics and Their Evolving Role in Prescription Drug Pricing and Access

Abstract Full Text
JAMA Intern Med. 2021;181(4):423-424. doi:10.1001/jamainternmed.2020.8450

This Viewpoint describes how authorized generics are used and discusses whether they improve access to prescription drugs or lower out-of-pocket spending for patients.

Perspective

Testimony of the Beirut Explosion—A White Coat Soaked in Blood and Tears

Abstract Full Text
JAMA Intern Med. 2021;181(4):425-426. doi:10.1001/jamainternmed.2020.8720

This article provides the perspective of a first-line responder after an explosion in Beirut, Lebanon, on August 4, 2020.

Original Investigation

Efficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial

Abstract Full Text
JAMA Intern Med. 2021;181(4):429-438. doi:10.1001/jamainternmed.2020.7101

This randomized clinical trial determines the efficacy of a 6-week combination of conservative treatments vs an education comparator for people with thumb base osteoarthritis.

Risk Factors Associated With All-Cause 30-Day Mortality in Nursing Home Residents With COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(4):439-448. doi:10.1001/jamainternmed.2020.7968

This cohort study examines risk factors for 30-day all-cause mortality among US nursing home residents with COVID-19.

Estimated SARS-CoV-2 Seroprevalence in the US as of September 2020

Abstract Full Text
open access has active quiz
JAMA Intern Med. 2021;181(4):450-460. doi:10.1001/jamainternmed.2020.7976

This cross-sectional study examines the prevalence of persons with SARS-CoV-2 antibodies across the US and changes from July to September 2020.

Evaluation of Cloth Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the COVID-19 Pandemic

Abstract Full Text
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JAMA Intern Med. 2021;181(4):463-469. doi:10.1001/jamainternmed.2020.8168

This comparative study examines the fitted filtration efficiency of 7 consumer-grade face masks and 5 medical procedure mask modifications.

Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic

Abstract Full Text
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JAMA Intern Med. 2021;181(4):471-478. doi:10.1001/jamainternmed.2020.8193

This cohort study examines variations in COVID-19 mortality rates and over the first 6 months of the pandemic.

Association of the Intensity of Diagnostic Evaluation With Outcomes in Incidentally Detected Lung Nodules

Abstract Full Text
JAMA Intern Med. 2021;181(4):480-489. doi:10.1001/jamainternmed.2020.8250

This comparative effectiveness research reports the radiation exposure, adverse events, and health expenditures associated with the varying intensities of lung nodule detection.

Assessment of Coverage in England of Cancer Drugs Qualifying for US Food and Drug Administration Accelerated Approval

Abstract Full Text
open access
JAMA Intern Med. 2021;181(4):490-498. doi:10.1001/jamainternmed.2020.8441

This cohort study assesses the concordance between cancer drug indications receiving accelerated approval from the US Food and Drug Administration between 1992 and 2017 and those subsequently authorized for funding through the National Health Service in England.

Evaluation of the Clinical Benefit of Cancer Drugs Submitted for Reimbursement Recommendation Decisions in Canada

Abstract Full Text
JAMA Intern Med. 2021;181(4):499-508. doi:10.1001/jamainternmed.2020.8588

This cohort study evaluates the quality of evidence in the drug submission process for provincial reimbursement of the pan-Canadian Oncology Drug Review.

Risk of Progression to Diabetes Among Older Adults With Prediabetes

Abstract Full Text
has active quiz has audio
JAMA Intern Med. 2021;181(4):511-519. doi:10.1001/jamainternmed.2020.8774

This cohort study of older adults without diabetes compares different prediabetes definitions and characterizes the risks of prediabetes and diabetes in this population.

Contents of US Food and Drug Administration Refuse-to-File Letters for New Drug Applications and Efficacy Supplements and Their Public Disclosure by Applicants

Abstract Full Text
open access
JAMA Intern Med. 2021;181(4):522-529. doi:10.1001/jamainternmed.2020.8866

This cross-sectional study analyzes the US Food and Drug Administration’s reasons for issuing refuse-to-file letters and assesses public transparency of refuse-to-file letters and their contents.

Effect of Telephone Cognitive Behavioral Therapy for Insomnia in Older Adults With Osteoarthritis Pain: A Randomized Clinical Trial

Abstract Full Text
JAMA Intern Med. 2021;181(4):530-538. doi:10.1001/jamainternmed.2020.9049

This randomized clinical trial evaluates the effectiveness of a telephone cognitive behavioral therapy for insomnia vs education-only control in older adults with moderate to severe osteoarthritis pain.

Editorial

Antibiotic Treatment for Inpatient Asthma Exacerbations: What Have We Learned?

Abstract Full Text
JAMA Intern Med. 2021;181(4):427-428. doi:10.1001/jamainternmed.2020.7229
Invited Commentary

Beyond Age—Improvement of Prognostication Through Physical and Cognitive Functioning for Nursing Home Residents With COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(4):448-449. doi:10.1001/jamainternmed.2020.8190

Antibodies, Immunity, and COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(4):460-462. doi:10.1001/jamainternmed.2020.7986

Decreased COVID-19 Mortality—A Cause for Optimism

Abstract Full Text
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JAMA Intern Med. 2021;181(4):478-479. doi:10.1001/jamainternmed.2020.8438

Approval and Coverage of Cancer Drugs in England, Canada, and the US

Abstract Full Text
JAMA Intern Med. 2021;181(4):509-510. doi:10.1001/jamainternmed.2020.8587

Less Is More

Prediabetes—A Risk Factor Twice Removed

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(4):520-521. doi:10.1001/jamainternmed.2020.8773
Editor's Note

Filtration Efficiency of Face Masks Used by the Public During the COVID-19 Pandemic

Abstract Full Text
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JAMA Intern Med. 2021;181(4):470. doi:10.1001/jamainternmed.2020.8234

Another Reason for Greater Transparency at the US Food and Drug Administration

Abstract Full Text
JAMA Intern Med. 2021;181(4):529. doi:10.1001/jamainternmed.2020.8841
Teachable Moment

Screening for Lipoprotein(a) Levels in Persons at Low Risk for Cardiovascular Disease: A Teachable Moment

Abstract Full Text
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JAMA Intern Med. 2021;181(4):539. doi:10.1001/jamainternmed.2020.8367

This Teachable Moment assesses cardiac risk in a 64-year-old woman with a history of breast cancer and paroxysmal atrial fibrillation and considers whether referral to cardiology and statin therapy are advisable.

The Toxic Effects of an Incomplete Medication History: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2021;181(4):540-541. doi:10.1001/jamainternmed.2020.8863

This Teachable Moment discusses the importance of the patient history in guiding diagnosis and treatment and offers strategies to overcome barriers in obtaining a thorough medication history.

Research Letter

Evaluation of Progress Toward Gender Equity Among Departmental Chairs in Academic Medicine

Abstract Full Text
JAMA Intern Med. 2021;181(4):548-550. doi:10.1001/jamainternmed.2020.6267

This cross-sectional study evaluates the extent of progress in female representation among program directors, chairs, and deans to provide a benchmark by which to evaluate future progress.

Prevalence of Personal Attacks and Sexual Harassment of Physicians on Social Media

Abstract Full Text
JAMA Intern Med. 2021;181(4):550-552. doi:10.1001/jamainternmed.2020.7235

This survey study examines the self-reports of personal attacks and sexual harassment of physicians through social media outlets.

Association of Diet and Lifestyle With the Risk of Gastroesophageal Reflux Disease Symptoms in US Women

Abstract Full Text
JAMA Intern Med. 2021;181(4):552-554. doi:10.1001/jamainternmed.2020.7238

This cohort study evaluated the joint association of dietary and lifestyle factors with risk of gastroesophageal reflux disease symptoms among women participating in the Nurses’ Health Study II.

Health Needs and Functional Disability Among Mail-Order Pharmacy Users in the US

Abstract Full Text
JAMA Intern Med. 2021;181(4):554-556. doi:10.1001/jamainternmed.2020.7254

This cross-sectional study examines the health characteristics of individuals who use mail-order pharmacies.

COVID-19 Test Result Turnaround Time for Residents and Staff in US Nursing Homes

Abstract Full Text
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JAMA Intern Med. 2021;181(4):556-559. doi:10.1001/jamainternmed.2020.7330

This cross-sectional study examines trends in test result turnaround rates for COVID-19 testing nursing facility residents and staff in hot spot counties in the US.

Speed, Evidence, and Safety Characteristics of Vaccine Approvals by the US Food and Drug Administration

Abstract Full Text
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JAMA Intern Med. 2021;181(4):559-560. doi:10.1001/jamainternmed.2020.7472

This cross-sectional study evaluates all of the novel vaccines approved by the US Food and Drug Administration over the last decade.

Engagement in Meaningful Activities Among Older Adults With Disability, Dementia, and Depression

Abstract Full Text
JAMA Intern Med. 2021;181(4):560-562. doi:10.1001/jamainternmed.2020.7492

This cross-sectional study examines the association between disability, dementia, and depression and engagement in meaningful activities in community-dwelling older adults.

Assessment of Filled Buprenorphine Prescriptions for Opioid Use Disorder During the Coronavirus Disease 2019 Pandemic

Abstract Full Text
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JAMA Intern Med. 2021;181(4):562-565. doi:10.1001/jamainternmed.2020.7497

This cohort study examines changes in the number of buprenorphine prescriptions fill by individuals with opioid use disorder before and during the coronavirus disease 2019 pandemic.

Challenges in Clinical Electrocardiography

Unusual Cause of Cardiac Arrest

Abstract Full Text
JAMA Intern Med. 2021;181(4):542-543. doi:10.1001/jamainternmed.2020.8370

This case report describes a patient with a history of remote coronary artery bypass grafting, heart failure with reduced ejection fraction, and poorly controlled insulin-dependent diabetes who presented with acute decompensated heart failure.

Atrioventricular Dissociation in a Heart Transplant Recipient

Abstract Full Text
JAMA Intern Med. 2021;181(4):544-545. doi:10.1001/jamainternmed.2020.8889

This case report describes a patient with a recent heart transplant who presented with syncope followed by asystole.

An Unusual Case of Chest Pain With Wide Complex Arrhythmia—No Stents Needed

Abstract Full Text
JAMA Intern Med. 2021;181(4):546-547. doi:10.1001/jamainternmed.2020.8999

This case report describes the electrocardiographic findings of a current smoker in their 50s with uncontrolled hypertension who presented with acute substernal chest pain and shortness of breath.

Comment & Response

What to Do With Sideline Guilt

Abstract Full Text
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JAMA Intern Med. 2021;181(4):565. doi:10.1001/jamainternmed.2020.6523

What to Do With Sideline Guilt

Abstract Full Text
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JAMA Intern Med. 2021;181(4):565. doi:10.1001/jamainternmed.2020.6529

What to Do With Sideline Guilt—Reply

Abstract Full Text
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JAMA Intern Med. 2021;181(4):565-566. doi:10.1001/jamainternmed.2020.6526

Negative Conversion Rate of SARS-CoV-2 Infection

Abstract Full Text
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JAMA Intern Med. 2021;181(4):566. doi:10.1001/jamainternmed.2020.7201

Negative Conversion Rate of SARS-CoV-2 Infection—Reply

Abstract Full Text
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JAMA Intern Med. 2021;181(4):566-567. doi:10.1001/jamainternmed.2020.7204

Substitution of Generic Drugs and Biosimilars

Abstract Full Text
JAMA Intern Med. 2021;181(4):567-568. doi:10.1001/jamainternmed.2020.8561

Health Care Policy and Law

Substitution of Generic Drugs and Biosimilars—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(4):568. doi:10.1001/jamainternmed.2020.8564

Possible Immortal Time Bias in Study of Antibiotic Treatment and Outcomes in Patients Hospitalized for Asthma

Abstract Full Text
JAMA Intern Med. 2021;181(4):568-569. doi:10.1001/jamainternmed.2020.7602

Notice of Retraction and Replacement. Stefan et al. Association of antibiotic treatment with outcomes in patients hospitalized for an asthma exacerbation treated with systemic corticosteroids. JAMA Intern Med. 2019;179(3):333-340

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JAMA Intern Med. 2021;181(4):569-570. doi:10.1001/jamainternmed.2020.7599

Notice of Retraction and Replacement. Stefan et al. Association of antibiotic treatment with outcomes in patients hospitalized for an asthma exacerbation treated with systemic corticosteroids. JAMA Intern Med. 2019;179(3):333-340.

Correction

Error in Quiz Answer Option

Abstract Full Text
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JAMA Intern Med. 2021;181(4):570. doi:10.1001/jamainternmed.2020.8212

Incorrect Answer in CME Online Quiz Questions

Abstract Full Text
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JAMA Intern Med. 2021;181(4):570. doi:10.1001/jamainternmed.2020.8943

Errors in Degree Symbols and Descriptors

Abstract Full Text
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JAMA Intern Med. 2021;181(4):570. doi:10.1001/jamainternmed.2020.8975

Error in Author Surname

Abstract Full Text
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JAMA Intern Med. 2021;181(4):570. doi:10.1001/jamainternmed.2020.8976

Replacement of Nonauthor Collaborator Names

Abstract Full Text
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JAMA Intern Med. 2021;181(4):570. doi:10.1001/jamainternmed.2021.0139

Errors in Data Presentation in Text, Table, and Supplement

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JAMA Intern Med. 2021;181(4):570. doi:10.1001/jamainternmed.2021.1321
JAMA Internal Medicine Masthead

JAMA Internal Medicine

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JAMA Intern Med. 2021;181(4):420. doi:10.1001/jamainternmed.2020.5261
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