Background All relevant authorities recommend an interval of 10 years between normal screening colonoscopies. We assessed the timing of repeated colonoscopies after a negative screening colonoscopy finding in a population-based sample of Medicare patients.
Methods A 5% national sample of Medicare enrollees from 2000 through 2008 was used to identify average-risk patients undergoing screening colonoscopy between 2001 and 2003. Colonoscopy was classified as a negative screening examination finding if no indication other than screening were in the claims and if no biopsy, fulguration, or polypectomy was performed. Time to repeated colonoscopy was calculated.
Results Among 24 071 Medicare patients who had a negative screening colonoscopy finding in 2001 through 2003, 46.2% underwent a repeated examination in fewer than 7 years. In 42.5% of these patients (23.5% of the overall sample), there was no clear indication for the early repeated examination. In patients aged 75 to 79 years or 80 years or older at the time of the initial negative screening colonoscopy result, 45.6% and 32.9%, respectively, received a repeated examination within 7 years. In multivariable analyses, male sex, more comorbidities, and colonoscopy by a high-volume colonoscopist or in an office setting were associated with higher rates of early repeated colonoscopy without clear indication, while those 80 years or older had a reduced risk. There were also marked geographic variations, from less than 5% in some health referral regions to greater than 50% in others.
Conclusions A large proportion of Medicare patients who undergo screening colonoscopy do so more frequently than recommended. Current Medicare regulations intending to limit reimbursement for screening colonoscopy to every 10 years would not appear to be effective.
The adoption of screening for colorectal cancer (CRC) has been accompanied by declines in CRC mortality.1 Colonoscopy is the screening modality preferred by authorities such as the American Cancer Society because of its ability to identify and remove precancerous lesions, thus reducing cancer incidence.2-4 Considerable attention has been given to the underuse of CRC screening, particularly screening colonoscopy.4-8 Ethnic minorities and the uninsured have substantially lower rates of colonoscopy as well as other CRC screening modalities.5,8 Limitations in the current endoscopist workforce have been cited as a barrier to increasing screening rates.6,7
Less attention has been paid to possible overuse of screening colonoscopy.9-11 Overuse is important for several reasons. First, screening colonoscopy can have adverse effects, including hospitalization and death.12-14 Too frequent performance of the examination may shift the benefit to risk ratio by increasing complications without additional benefit. Second, colonoscopy screening is costly; it is important to restrain expenditures for unnecessary procedures. Third, colonoscopy is a limited resource, in terms of facilities and practitioners.6,7 Identifying and decreasing overuse of screening colonoscopy should free up resources to increase appropriate colonoscopy in inadequately screened populations.
Most patients at initial screening colonoscopy have no findings relevant to cancer, such as polyps.15-19 In such patients, the time interval for a repeated examination recommended by all expert panels is 10 years.2-4 The objective of this study is to determine the frequency of early repeated colonoscopy after a negative screening colonoscopy finding among fee-for-service Medicare patients in the United States and to examine its association with demographic variables, health care provider specialty, and location of service.
Our overall approach involved identifying subjects with a negative screening colonoscopy finding between 2001 and 2003 and determining what percentage of them had an additional colonoscopy between 2001 and 2008. The selection of the subjects is outlined in Figure 1. We used the claims and enrollment data for the 2000-2008 period from a 5% random national sample of Medicare beneficiaries. We first identified a cohort of patients 66 years or older with parts A and B Medicare and not enrolled in a health maintenance organization, who underwent a complete colonoscopy between 2001 and 2003 (n = 236 145).
The identification of screening colonoscopy is complicated by the fact that few colonoscopies are submitted using the screening code (eg, 4.6% in 2001 and 14.6% in 2007-2008), although approximately two-thirds of colonoscopies are estimated to be performed for CRC screening.8 In addition, Medicare will not reimburse for a screening colonoscopy within 10 years after a negative examination result, consistent with all guidelines.2-4
Our approach to identifying negative screening colonoscopy results was to define several successive cohorts from the 236 145 beneficiaries who underwent a complete colonoscopy between 2001 and 2003 (Figure 1). First, we eliminated all colonoscopies that were accompanied by a biopsy, fulguration, or any other procedure. This left 114 468 patients with what we considered a negative colonoscopy result. We should note that findings from colonoscopies with biopsies or other procedures might also be negative. For example, a biopsy result might be normal. However, we had no way to identify such cases, so all colonoscopies with a procedure were excluded. Also, the term negative is limited to cancer screening. These colonoscopies might have found other abnormalities, such as internal hemorrhoids or diverticula.
The next step was to exclude any colonoscopy with a diagnosis suggesting a nonscreening indication or if there were prior diagnoses or procedures suggesting that there might be an indication other than screening. We excluded colonoscopies if there was a claim for barium enema or abdominal computerized tomography in the prior 3 months, or if there was a diagnosis on the colonoscopy claim or on any inpatient or outpatient claim in the prior 3 months for anemia, gastrointestinal tract (GI) bleeding, change in bowel habits, abdominal pain, irritable bowel syndrome, ischemic bowel disease, history of colon cancer, or any other condition for which a colonoscopy might plausibly be indicated (see eAppendix). If the primary diagnosis on the colonoscopy claim was diverticular disease and there was evidence of diverticulitis on prior claims, those colonoscopies were excluded. We also excluded those with any diagnosis of CRC, inflammatory bowel disease, or familial polyposis syndromes on the colonoscopy claim or in the 12 months prior to colonoscopy or those who had procedures or diagnoses suggestive of colon cancer in the month after colonoscopy. All other colonoscopies were categorized as a negative screening colonoscopy result (N = 24 071).
The study outcome was the first repeated colonoscopy in the period starting at 3 months after the initial examination between 2001 and 2003 and ending at December 31, 2008. Beneficiaries were censored at death, loss of coverage, or end of follow-up. The repeated colonoscopies were classified as “probably indicated,” “possibly indicated,” or “no clear indication,” based on the following approach. First, we examined the diagnosis on the colonoscopy claim and also all diagnoses on inpatient and outpatient claims in the 3 months prior to the colonoscopy. If there was a diagnosis on the claim that might represent an indication for diagnostic colonoscopy, and if that or any other diagnosis consistent with an indication for diagnostic colonoscopy were present in the claims in the 3 months prior, the colonoscopy was considered as probably indicated. If a diagnosis consistent with an indication for diagnostic colonoscopy were present in only one of the sources (colonoscopy claim or claims in the prior 3 months), this was labeled as possibly indicated. Colonoscopies with no relevant diagnoses on the colonoscopy claim or in the prior 3 months were labeled as “without indication.” The indications for diagnostic colonoscopy are the same as those used to categorize the baseline colonoscopy and are listed in the eAppendix.
Age, sex, race, and zip code and region of residence of each beneficiary were obtained from the Medicare enrollment file. Education for zip code areas were obtained from the 2000 Census data. Urban/rural was categorized by Rural-Urban Continuum Codes.20 Comorbidity measures were generated from all claims in the year prior to the baseline colonoscopy,21 with conditions possibly related to a clinical indication for colonoscopy (anemia and weight loss) excluded (see footnote to Table 1 for a list of included comorbidities). Physician specialty was obtained from Medicare Part B claims. Volume of colonoscopies by the endoscopist who performed the baseline colonoscopy was assessed between 2001 and 2003.
The rates of early repeated colonoscopy were estimated by the Kaplan-Meier method. Hospital referral regions described in the Dartmouth Atlas of Health Care22 were used to assess regional variation. Multivariable survival analyses were performed using the Cox proportional hazards model. All analyses were performed using SAS version 9.1 statistical software (SAS Institute, Cary, North Carolina).
Figure 2 shows the cumulative percentage of repeated colonoscopies over the 7 years following the initial colonoscopy in 2001 through 2003. Curves for 3 different cohorts are given: all patients who underwent complete colonoscopies in 2001 through 2003, all those with complete colonoscopies with negative results in 2001 through 2003, and those with complete negative colonoscopy results with no indication other than screening in 2001 through 2003. For the 236 145 patients who underwent complete colonoscopy in 2001 through 2003, the rates of repeated colonoscopy at 5 and 7 years were 43.3% and 59.5%, respectively. For those with negative examination results in 2001 through 2003, the repeated colonoscopy rates at 5 and 7 years were 31.9% and 50.1%, respectively, and for those with no indications other than screening and a negative examination result, the repeated colonoscopy rates at 5 and 7 years were 24.6% and 46.2%, respectively. With all 3 lines, one can note inflection points at approximately 3 and 5 years after the initial colonoscopy, suggesting that those colonoscopies were performed as part of a routine scheduled follow-up. All other analyses in this article relate to the cohort with a negative screening baseline colonoscopy finding in 2001 through 2003, the bottom line in Figure 2.
Table 1 details the characteristics of the patients with negative screening colonoscopy findings in 2001 through 2003, and the percentage of patients who underwent a repeated colonoscopy examination within 7 years after the negative screening colonoscopy result, stratified by patient and health care provider characteristics. Because of the large sample, almost all variations are statistically significant. Therefore, it is important to focus on the magnitude of any differences, rather than statistical significance. Surprisingly, 45.6% of patients aged 75 to 79 years and one-third of patients 80 years or older at the time of the initial negative screening colonoscopy result underwent a repeated colonoscopy within 7 years. Male sex, black race, and more comorbidities were all associated with a higher rate of early repeated colonoscopy. The rate of early repeated colonoscopy by geographic region ranged from 39.8% to 54.6%. The rate of early repeated colonoscopy was greater in patients whose initial colonoscopy was performed in an office setting and whose initial colonoscopy was performed by a physician who performed a high volume of colonoscopies. Also given in Table 1 is the percentage of patients who underwent an early repeated colonoscopy with no clear indication other than screening.
Among the patients with a repeated colonoscopy within 7 years after a negative screening colonoscopy, 26.9% had a diagnosis on the colonoscopy claim consistent with a medical indication for the repeated examination. These included anemia, abdominal pain, constipation, change in bowel habits, hemorrhoids, and weight loss (a complete list is given in the eAppendix). The diagnoses listed on the claims for the repeated colonoscopies are given in Table 2, along with any diagnoses or procedures in the 3 months prior to the repeated examination that might represent an indication. For example, 1252 claims for repeated colonoscopies listed anemia or GI bleeding as the indication. In 887 of these, there were diagnoses or procedures in the prior 3 months that could be consistent with anemia or GI bleeding or that might represent another indication for colonoscopy, such as change in bowel habits, constipation, or weight loss. These repeated colonoscopies were classified as probably indicated. The remaining 365 of the 1252 repeated colonoscopies with an anemia/GI bleeding indication and no prior procedure or related diagnosis were classified as possibly indicated. In 1955 early repeated colonoscopies, diverticulosis (n = 1588) or another unrelated diagnosis (n = 367) were listed as the indication on the claim (Table 2). Diverticulosis is not an indication for colonoscopy, but it might be considered appropriate for evaluation of a prior episode of acute diverticulitis. Only 4.6% of the patients had such diagnosis in the prior claims, and 49.2% had 1 or more other potential indications for colonoscopy listed in the 3 months prior. Thus, 52.4% of the colonoscopies with a diverticulosis indication were listed as possibly indicated and the remaining 47.6% as without indication. Approximately half of the early repeated colonoscopies were accompanied by diagnoses that suggested that the colonoscopy was performed for screening. These diagnoses included benign neoplasm of the colon, history of polyps, screening for colon cancer, and family history of colon cancer. In 37.2% of those cases, there were procedures or diagnoses in the prior 3 months consistent with a nonscreening indication for colonoscopy. These cases were considered possibly indicated, and the remaining 62.8% were considered without indications.
Using that strategy, we classified 57.5% of the early repeated colonoscopies as possibly or probably indicated, while 42.5% were without indications (Table 2). Of the 3656 claims for colonoscopies without clear indications, only 86 (2%) were denied reimbursement by Medicare. As noted previously, the curves of cumulative percentage of early repeated colonoscopies in Figure 1 show inflection points with noticeable increases in the rate of repeated colonoscopies at 3 and 5 years, suggesting that those procedures might have been routinely scheduled rather than in response to symptoms. To investigate this, we selected colonoscopies that occurred 59 to 65 months after the baseline colonoscopy and calculated the percentage that were without indication. That percentage was 61.5%, compared with 42.5% for the entire sample.
We repeated the analyses in Table 1 and Table 2, excluding those with a family history of GI cancer both from the initial negative screening colonoscopy cohort and from those identified as undergoing early repeated colonoscopy with no clear indication. Using that method, we found that the percentage of patients undergoing early repeated colonoscopy and early repeated colonoscopy without clear indication were similar to those in Table 1 (45.5% vs 46.2% and 21.8% vs 23.5%, respectively).
Table 3 presents the results of a multivariable analysis examining the independent associations of patient and health care provider characteristics with the hazard of early repeated colonoscopy. We present a model for the hazard of any repeated colonoscopy within 7 years and also a model assessing hazard for patients who had no clear indication for the repeated examination.
In both models, the hazard was lower in patients 75 and older at the time of their initial examination. It was also lower in women, in those with fewer comorbidities, in those residing in zip codes with lower educational levels, and in those residing outside of large metropolitan areas. Patients receiving their initial examination in an office setting were more likely to undergo an early repeated examination, as were those whose initial examinations were by endoscopists in with high volumes of colonoscopies. The variation by census region was similar to the unadjusted analyses, with patients in the New England, Mountain, and Pacific regions at the lowest risk for early repeated colonoscopy.
We further explored the geographic variation in early repeated colonoscopy after a negative screening colonoscopy finding by examining those rates at the level of the 306 US health referral regions (HRRs). Those analyses were restricted to patients with no clear indication for the repeated examination. Figure 3 shows marked variation, with rates higher than 50% in Pueblo, Colorado, and Bryan, Texas, and lower than 5% in many HRRs. Of interest is the juxtaposition of HRRs with very high and very low rates in the same state, such as in Colorado, Texas, Wisconsin, and California.
The analyses in this study were based on a number of assumptions. One is that colonoscopy results can be classified as negative if not accompanied by a biopsy, polypectomy, or other procedure. We reasoned that the class of abnormalities associated with colon cancer would almost always trigger a procedure. This strategy would tend to underestimate the true prevalence of negative examination results; eg, biopsy finding can be negative. Another assumption is that the colonoscopies were performed for screening purposes rather than for evaluating a sign or symptom. We reasoned that a diagnostic colonoscopy for conditions such as anemia, GI bleeding, change in bowel habit, or abdominal pain would produce relevant diagnoses in the colonoscopy claim or in physician claims in the prior 3 months.
An alternative approach would be to limit the baseline cohort to those with a charge for a screening rather than a diagnostic colonoscopy. This is problematic because many endoscopists continued to use diagnostic codes for those cases even after Medicare initiated reimbursement for screening colonoscopy in 2001 for men and women 50 years or older at average risk. For example, the percentage of all Medicare colonoscopies with a screening code was only 4.6% in 2001 and 14.6% in 2007 through 2008, while an estimated two-thirds of all colonoscopies are performed for CRC screening.8 In one validation study, approximately half of the procedures that had a nonscreening indication in the Medicare claims were listed as screening in the medical record.23
The final cohort of negative screening colonoscopy results represented only 10.2% of all complete colonoscopies in 2001 through 2003. This is clearly a gross underestimate of the true percentage of screening colonoscopies.8 However, the method we used to create the cohort should ensure a very high specificity for negative screening colonoscopy results. This method also tends to underestimate the rate of early repeated colonoscopies. We examined a large number of ways to stratify the cohort of 236 145 individuals with complete colonoscopies in 2001 through 2003. The rate of repeated colonoscopies within 7 years was never lower than 45%. When we examined all patients who received colonoscopies between 2001 and 2003, the repeat rate at 7 years was 59.5%. Thus, the actual practice of colonoscopy in the community seems quite different from the assumptions made in assessing the cost-effectiveness of CRC screening by colonoscopy.24
Overall, 57.5% of the early repeated colonoscopies were accompanied by a diagnosis that might represent a legitimate indication for an examination. This proportion dropped to 38.5% when we examined the colonoscopies done around the inflection point at 60 months shown in Figure 1. The rapid increase in colonoscopies in the period around 60 months suggests that those might have been routinely scheduled, a concept supported by the lower percentage of legitimate indications included in the claims for these examinations.
The estimates of repeated colonoscopy within 7 years produces a highly conservative estimate of potential overuse of screening colonoscopy, given that no guidelines recommend a screening interval of fewer than 10 years after a negative examination result.2-4 We lack full 10-year follow-up data, since Medicare initiated reimbursement for screening colonoscopy for normal-risk individuals in 2001.
Several other findings of this study bear consideration. First, one-third of patients 80 years or older at their initial negative screening examination result underwent a repeated screening examination within 7 years. This is of special concern, given the increased potential for complications and decreased benefit of this examination in the very old.9,16,25 The US Preventive Services Task Force recommends against routine screening in those aged between 75 and 84 years and against any screening of those 85 years or older.25 A second finding of concern is that older patients with 3 or more comorbidities were much more likely to undergo early repeated screening colonoscopy. Because increasing comorbidity is closely linked to decreasing life expectancy, any potential benefit from identifying and removing precancerous lesions would be considerably lower in these patients.16,26,27 It is unclear why such patients are actually more likely to be tested. We had removed from the comorbidity measure any diagnoses that might be indications for colonoscopy. It may be that patients with multiple comorbidities see more medical providers, increasing their risk of being recommended for another screening colonoscopy.
A limitation of this study is the lack of information on the quality of the initial colonoscopy. Early repeated colonoscopies could result from incomplete or poor-quality initial colonoscopies. However, we eliminated patients with incomplete initial colonoscopies from the analyses. Also, one would expect repeated colonoscopies to follow up on suspicious findings to occur relatively soon after the initial colonoscopy, which is not the temporal pattern we found (Figure 2).
Another limitation is that we studied patients 66 years or older with fee-for-service Medicare coverage. The results may not be applicable to younger patients, and we doubt that they are applicable to patients in health maintenance organizations.
The evidence base for the determination of optimal spacing for screening colonoscopy is limited. Indeed, there are no randomized prospective trials of screening colonoscopy, though both observational data and our understanding of tumor biology are strongly supportive.1,25,28 An understanding of tumor biology also underlies the recommendations on frequency of screening colonoscopy.25,28,29 Investigators at the Mayo Clinic identified 226 patients with colonic polyps found by barium enema examination in the precolonoscopy era.28 Three-quarters of the polyps were 10 to 15 mm in diameter, and the rest were larger. These patients were then followed up with periodic barium enema examinations. The rate of conversion to cancer of these large polyps was 2.5% at 5 years and 8% at 10 years, with greater than 70% without nodal involvement or distant spread at surgery.28 This relatively slow rate of progression to cancer of large polyps underlies the recommendation for a 10-year interval following a negative colonoscopy result or a colonoscopy finding of a few small polyps.23
Few quality indicators deal with the overuse of diagnostic tests or treatments for a condition.30 Medicare regulations preclude reimbursement for screening colonoscopy within 10 years of a negative examination result. However, only 2% of the claims for early repeated colonoscopies without indication were denied. Identification of claims for early repeated colonoscopy without an indication other than screening is complicated by the seeming underuse of the screening code in colonoscopies billed to Medicare.
Early repeated colonoscopies without clear indication compose a substantial proportion of the present endoscopist workload and also represents substantial Medicare expenditures. There also seems to be considerable divergence between the current recommendations and the opinions of colonoscopists on appropriate screening intervals,31,32 even though those recommendations have been stable over the past 3 decades.2,3 A recent Institute of Medicine report recommended the development of monitoring systems to identify patterns of overuse of CRC screening.9 Our analyses, when applied to 100% Medicare data (in contrast to the 5% sample used), should be able to identify individual endoscopists with patterns of potential overuse, such as early repeated colonoscopy without indications or screening colonoscopy in very old patients. Such findings could then trigger audits involving medical chart reviews. Pressure from patients may also lead to inappropriate screening.33 Given the increasing public interest in and ownership of cancer screening,33,34 public information campaigns that emphasize both the necessity for CRC screening as well as the dangers of overuse may prove beneficial in reducing overuse.
Correspondence: James S. Goodwin, MD, 301 University Blvd, RSH–6.622, University of Texas Medical Branch, Galveston, TX 77555-0177 (jsgoodwi@utmb.edu).
Accepted for Publication: March 1, 2011.
Published Online: May 9, 2011. doi:10.1001/archinternmed.2011.212
Author Contributions:Study concept and design: Goodwin, Reddy, Riall, and Kuo. Acquisition of data: Goodwin. Analysis and interpretation of data: Goodwin, Singh, Reddy, Riall, and Kuo. Drafting of the manuscript: Goodwin, Reddy, and Riall. Critical revision of the manuscript for important intellectual content: Singh and Kuo. Statistical analysis: Kuo. Obtained funding: Goodwin. Administrative, technical, and material support: Goodwin and Singh. Study supervision: Goodwin and Riall.
Financial Disclosure: None reported.
Funding/Support: This study was supported by grants K05CA134923 and R01CA134275 from the National Institutes of Health and grant RP101207 from the Cancer Prevention and Research Institute of Texas.
Additional Contributions: Sarah Toombs Smith, PhD, and Kelley Prevou assisted in the preparation of the manuscript.
1.Edwards BK, Ward E, Kohler BA,
et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates.
Cancer. 2010;116(3):544-57319998273
PubMedGoogle ScholarCrossref 2.Levin B, Lieberman DA, McFarland B,
et al; American Cancer Society Colorectal Cancer Advisory Group; US Multi-Society Task Force; American College of Radiology Colon Cancer Committee. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
Gastroenterology. 2008;134(5):1570-159518384785
PubMedGoogle ScholarCrossref 3.Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM.American College of Gastroenterology. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected].
Am J Gastroenterol. 2009;104(3):739-75019240699
PubMedGoogle ScholarCrossref 4.Davila RE, Rajan E, Baron TH,
et al; Standards of Practice Committee, American Society for Gastrointestinal Endoscopy. ASGE guideline: colorectal cancer screening and surveillance.
Gastrointest Endosc. 2006;63(4):546-55716564851
PubMedGoogle ScholarCrossref 5.Centers for Disease Control and Prevention (CDC). Vital signs: colorectal cancer screening among adults aged 50-75 years—United States, 2008.
MMWR Morb Mortal Wkly Rep. 2010;59(26):808-81220613704
PubMedGoogle Scholar 6.Seeff LC, Manninen DL, Dong FB,
et al. Is there endoscopic capacity to provide colorectal cancer screening to the unscreened population in the United States?
Gastroenterology. 2004;127(6):1661-166915578502
PubMedGoogle ScholarCrossref 7.Brown ML, Klabunde CN, Mysliwiec P. Current capacity for endoscopic colorectal cancer screening in the United States: data from the National Cancer Institute Survey of Colorectal Cancer Screening Practices.
Am J Med. 2003;115(2):129-13312893399
PubMedGoogle ScholarCrossref 8.Chao A, Connell CJ, Cokkinides V, Jacobs EJ, Calle EE, Thun MJ. Underuse of screening sigmoidoscopy and colonoscopy in a large cohort of US adults.
Am J Public Health. 2004;94(10):1775-178115451749
PubMedGoogle ScholarCrossref 9.Holden DJ, Harris R, Porterfield DS,
et al. Enhancing the Use and Quality of Colorectal Cancer Screening: Evidence Report/Technology Assessment No. 190 (Prepared by the RTI International-University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I) Rockville, MD: Agency for Healthcare Research and Quality. February 2010. AHRQ publication 10-E-002
10.Song Y, Skinner J, Bynum J, Sutherland J, Wennberg JE, Fisher ES. Regional variations in diagnostic practices.
N Engl J Med. 2010;363(1):45-5320463332
PubMedGoogle ScholarCrossref 11.Holden DJ, Jonas DE, Porterfield DS, Reuland D, Harris R. Systematic review: enhancing the use and quality of colorectal cancer screening.
Ann Intern Med. 2010;152(10):668-67620388703
PubMedGoogle Scholar 12.Levin TR, Zhao W, Conell C,
et al. Complications of colonoscopy in an integrated health care delivery system.
Ann Intern Med. 2006;145(12):880-88617179057
PubMedGoogle Scholar 13.Arora G, Mannalithara A, Singh G, Gerson LB, Triadafilopoulos G. Risk of perforation from a colonoscopy in adults: a large population-based study.
Gastrointest Endosc. 2009;69(3, pt 2):654-66419251006
PubMedGoogle ScholarCrossref 14.Warren JL, Klabunde CN, Mariotto AB,
et al. Adverse events after outpatient colonoscopy in the Medicare population.
Ann Intern Med. 2009;150(12):849-857, W15219528563
PubMedGoogle Scholar 15.Prajapati DN, Saeian K, Binion DG,
et al. Volume and yield of screening colonoscopy at a tertiary medical center after change in Medicare reimbursement.
Am J Gastroenterol. 2003;98(1):194-19912526957
PubMedGoogle ScholarCrossref 16.Lin OS, Kozarek RA, Schembre DB,
et al. Screening colonoscopy in very elderly patients: prevalence of neoplasia and estimated impact on life expectancy.
JAMA. 2006;295(20):2357-236516720821
PubMedGoogle ScholarCrossref 17.Schoenfeld P, Cash B, Flood A,
et al; CONCeRN Study Investigators. Colonoscopic screening of average-risk women for colorectal neoplasia.
N Engl J Med. 2005;352(20):2061-206815901859
PubMedGoogle ScholarCrossref 18.Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G.Veterans Affairs Cooperative Study Group 380. Use of colonoscopy to screen asymptomatic adults for colorectal cancer.
N Engl J Med. 2000;343(3):162-16810900274
PubMedGoogle ScholarCrossref 19.Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings.
N Engl J Med. 2000;343(3):169-17410900275
PubMedGoogle ScholarCrossref 21.Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data.
Med Care. 1998;36(1):8-279431328
PubMedGoogle ScholarCrossref 23.Schenck AP, Klabunde CN, Warren JL,
et al. Data sources for measuring colorectal endoscopy use among Medicare enrollees.
Cancer Epidemiol Biomarkers Prev. 2007;16(10):2118-212717932360
PubMedGoogle ScholarCrossref 24.Frazier AL, Colditz GA, Fuchs CS, Kuntz KM. Cost-effectiveness of screening for colorectal cancer in the general population.
JAMA. 2000;284(15):1954-196111035892
PubMedGoogle ScholarCrossref 25.US Preventive Services Task Force. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement.
Ann Intern Med. 2008;149(9):627-63718838716
PubMedGoogle Scholar 26.Braithwaite RS, Fiellin D, Justice AC. The payoff time: a flexible framework to help clinicians decide when patients with comorbid disease are not likely to benefit from practice guidelines.
Med Care. 2009;47(6):610-61719433991
PubMedGoogle ScholarCrossref 27.Gross CP, McAvay GJ, Krumholz HM, Paltiel AD, Bhasin D, Tinetti ME. The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening.
Ann Intern Med. 2006;145(9):646-65317088577
PubMedGoogle Scholar 28.Stryker SJ, Wolff BG, Culp CE, Libbe SD, Ilstrup DM, MacCarty RL. Natural history of untreated colonic polyps.
Gastroenterology. 1987;93(5):1009-10133653628
PubMedGoogle Scholar 29.Peipins LA, Sandler RS. Epidemiology of colorectal adenomas.
Epidemiol Rev. 1994;16(2):273-2977713180
PubMedGoogle Scholar 30. McGlynn EA, Asch SM, Adams J,
et al. The quality of health care delivered to adults in the United States.
N Engl J Med. 2003;348(26):2635-264512826639
PubMedGoogle ScholarCrossref 31.Mysliwiec PA, Brown ML, Klabunde CN, Ransohoff DF. Are physicians doing too much colonoscopy? a national survey of colorectal surveillance after polypectomy.
Ann Intern Med. 2004;141(4):264-27115313742
PubMedGoogle Scholar 32.Krist AH, Jones RM, Woolf SH,
et al. Timing of repeat colonoscopy: disparity between guidelines and endoscopists' recommendation.
Am J Prev Med. 2007;33(6):471-47818022063
PubMedGoogle ScholarCrossref 33.Schwartz LM, Woloshin S, Fowler FJ Jr, Welch HG. Enthusiasm for cancer screening in the United States.
JAMA. 2004;291(1):71-7814709578
PubMedGoogle ScholarCrossref 34.Cram P, Fendrick AM, Inadomi J, Cowen ME, Carpenter D, Vijan S. The impact of a celebrity promotional campaign on the use of colon cancer screening: the Katie Couric effect.
Arch Intern Med. 2003;163(13):1601-160512860585
PubMedGoogle ScholarCrossref