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In This Issue of Archives of Internal Medicine
June 11, 2012

In This Issue of Archives of Internal Medicine

Arch Intern Med. 2012;172(11):833. doi:10.1001/archinternmed.2011.952

n this study, Fine et al performed national-scale validations of the Centor and McIsaac scores for predicting group A streptococcal pharyngitis. Leveraging retail health data from more than 200 000 patients with sore throat, the study provides more precise estimates of a patient's risk of group A streptococcal infection based on a geographically diverse population, thus aiding clinical decision making.

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This systematic review with meta-analysis by Gellert et al aimed to provide an overview on the empirical evidence of the association of smoking with all-cause mortality in people 60 years and older. Seventeen studies from 7 countries were identified after a systematic literature search. Current smoking was associated with increased all-cause mortality in all studies; relative mortality (RM) of current smokers compared with never smokers was 1.83 (95% CI, 1.65-2.03) in meta-analysis. A moderate decrease of RM with increasing age was observed, but mortality remained increased up to the highest ages. Furthermore, a dose-response relationship of the amount of smoked cigarettes and premature death was found. Former smokers also showed increased mortality (meta-analysis: RM, 1.34; 95% CI, 1.28-1.40), but excess mortality compared with never smokers clearly decreased with duration of cessation. Smoking remains a strong risk factor for premature mortality also at older age.