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Leung et al performed a multicenter cohort study of 964 263 cases from nearly 300 hospitals using the America College of Surgeons–National Surgical Quality Improvement Program database to determine the association between preoperative hyponatremia and 30-day perioperative outcomes. The investigators found that patients with hyponatremia, compared with those with normal baseline sodium levels, had greater odds of perioperative death, and this association was present for all subgroups without exception. There were likewise increased odds of major coronary events, surgical site infections, and pneumonia. These findings suggest that hyponatremia, when detected preoperatively, should be considered a marker for perioperative complications.
In This Issue of Archives of Internal Medicine. Arch Intern Med. 2012;172(19):1437. doi:10.1001/archinternmed.2011.992
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