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Research Letter
Jan 28, 2013

Availability of DMAA Supplements Despite US Food and Drug Administration Action

Author Affiliations

Author Affiliations: Natural Medicines Comprehensive Database, Stockton, California, and Pharmacy Practice, Center for Drug Information and Evidence-Based Practice, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska.

JAMA Intern Med. 2013;173(2):164-165. doi:10.1001/2013.jamainternmed.724

The stimulant DMAA, also known as 1,3-dimethylamylamine, has been the subject of much controversy.1 In the United States, it is currently marketed as a dietary supplement, primarily in products promoted as a preworkout supplement for boosting strength, energy, and power. Two of the most prominent supplements containing DMAA are “Jack3d” and “OxyELITE Pro” (USP Labs) However, there are over 250 commercial dietary supplements containing DMAA on the market.2

As has been reported elsewhere,1 DMAA supplements are immensely popular among consumers. However, there is great concern among health professionals and regulators for several reasons. First, it is unlikely that DMAA is truly of natural origin. Therefore, its marketing as a dietary supplement may be illegitimate. Second, there are significant safety concerns. To date, there have been over 40 reports of serious adverse events, including at least 2 reports of death.2,3