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In This Issue of JAMA Internal Medicine
October 14, 2013


JAMA Intern Med. 2013;173(18):1665-1667. doi:10.1001/jamainternmed.2013.6323

Low 25-hydroxyvitamin D (25OHD) levels have been associated with higher blood pressure (BP) and with future cardiovascular events. Witham and coauthors conducted a randomized clinical trial of high-dose, intermittent, oral vitamin D3 supplementation in 159 patients 70 years and older with isolated systolic hypertension, the commonest type of hypertension in older people. Despite significant increases in circulating 25OHD levels in the intervention group, no effect on office BP or 24-hour ambulatory BP was evident; surrogate markers of vascular function, including measures of arterial stiffness and endothelial function, also failed to improve with vitamin D3 supplementation. In an Invited Commentary, Giovannucci looks at the evidence base for vitamin D3 supplementation for isolated systolic hypertension and calls for further research.