The Archives of Internal Medicine, along with JAMA and other Archives journals, will publish a special theme issue in March 2010 on Cancer. We invite submission of papers as Clinical Trials, Original Investigations, Systematic Reviews, and Research Letters. We are interested in articles on the treatment and prevention of cancer, management of conditions associated with cancer (eg, pain, depression), the psychosocial care of patients with cancer, and issues facing practicing clinicians in caring for people with cancer as well as issues related to costs of chemotherapy, evaluating new chemotherapy, the role of surrogate markers, and issues related to the Cancer Compendium. Papers submitted by October 1, 2009, will have the best opportunity to be considered for this theme issue.