Across all hospitals, the change in mean DOT per 1000 patient-days were estimated by generalized estimating equation models controlling for case mix index, average patient age, bed size category, teaching status, urban or rural facility location, proportion of surgical discharges, average comorbidity score, facility geographic location, critical care setting, and proportion of inpatient-days in which the International Classification of Diseases, Ninth Revision, Clinical Modification21 diagnosis code was related to an infection. Data points represent mean DOT per 1000 patient-days for each antibiotic class, and the whiskers represent 95% CIs. DOT indicates days of therapy.
Across all hospitals, the mean DOT per 1000 patient-days by census division were estimated by generalized estimating equation models controlling for year, case mix index, average patient age, bed size category, teaching status, urban or rural facility location, proportion of surgical discharges, average comorbidity score, facility geographic location, critical care setting, and proportion of inpatient-days in which the International Classification of Diseases, Ninth Revision, Clinical Modification21 diagnosis code was related to an infection. DOT indicates days of therapy.
eFigure 1. Days of Therapy (DOT) / 1,000 Patient-days by Antibiotic Class for Critical Care and non-Critical Care locations, 2006-2012 Truven MarketScan Hospital Drug Database
eFigure 2. Proportion of Mean Days of Therapy / 1,000 Patient-days by Antibiotic Class over Time from 2006-2012, Truven MarketScan Hospital Drug Database
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Baggs J, Fridkin SK, Pollack LA, Srinivasan A, Jernigan JA. Estimating National Trends in Inpatient Antibiotic Use Among US Hospitals From 2006 to 2012. JAMA Intern Med. 2016;176(11):1639–1648. doi:10.1001/jamainternmed.2016.5651
How much antibiotic use occurs in US hospitals, and has the pattern of use changed over time?
Overall rates of antibiotic use in US hospitals did not change significantly from 2006 to 2012; however, use of certain antibiotic classes, including glycopeptides, β-lactam/β-lactamase inhibitor combinations, and carbapenems, increased significantly.
Patterns of antibiotic use in US hospitals may have important implications for reducing antibiotic-resistant infections; these findings can help inform national efforts to improve antibiotic use by suggesting key targets for improvement.
The rising threat of antibiotic resistance and other adverse consequences resulting from the misuse of antibiotics requires a better understanding of antibiotic use in hospitals in the United States.
To use proprietary administrative data to estimate patterns of US inpatient antibiotic use in recent years.
Design, Setting, and Participants
For this retrospective analysis, adult and pediatric in-patient antibiotic use data was obtained from the Truven Health MarketScan Hospital Drug Database (HDD) from January 1, 2006, to December 31, 2012. Data from adult and pediatric patients admitted to 1 of approximately 300 participating acute care hospitals provided antibiotic use data for over 34 million discharges representing 166 million patient-days.
Main Outcomes and Measures
We retrospectively estimated the days of therapy (DOT) per 1000 patient-days and the proportion of hospital discharges in which a patient received at least 1 dose of an antibiotic during the hospital stay. We calculated measures of antibiotic usage stratified by antibiotic class, year, and other patient and facility characteristics. We used data submitted to the Centers for Medicare and Medicaid Services Healthcare Cost Report Information System to generate estimated weights to apply to the HDD data to create national estimates of antibiotic usage. A multivariate general estimating equation model to account for interhospital covariance was used to assess potential trends in antibiotic DOT over time.
During the years 2006 to 2012, 300 to 383 hospitals per year contributed antibiotic data to the HDD. Across all years, 55.1% of patients received at least 1 dose of antibiotics during their hospital visit. The overall national DOT was 755 per 1000 patient-days. Overall antibiotic use did not change significantly over time. The multivariable trend analysis of data from participating hospitals did not show a statistically significant change in overall use (total DOT increase, 5.6; 95% CI, −18.9 to 30.1; P = .65). However, the mean change (95% CI) for the following antibiotic classes increased significantly: third- and fourth-generation cephalosporins, 10.3 (3.1-17.5); macrolides, 4.8 (2.0-7.6); glycopeptides, 22.4 (17.5-27.3); β-lactam/β-lactamase inhibitor combinations, 18.0 (13.3-22.6); carbapenems, 7.4 (4.6-10.2); and tetracyclines, 3.3 (2.0-4.7).
Conclusions and Relevance
Overall DOT of all antibiotics among hospitalized patients in US hospitals has not changed significantly in recent years. Use of some antibiotics, especially broad spectrum agents, however, has increased significantly. This trend is worrisome in light of the rising challenge of antibiotic resistance. Our findings can help inform national efforts to improve antibiotic use by suggesting key targets for improvement interventions.
Owing to the rising threat of antibiotic resistance and other consequences resulting from unnecessary antibiotic use, ensuring appropriate antibiotic usage in the United States has become a national priority.1-4 In response, the US government has developed The National Strategy for Combating Antibiotic-Resistant Bacteria.2,5 Antibiotic use surveillance is a key objective within that strategy and a core element of hospital antibiotic stewardship programs identified by the Centers for Disease Control and Prevention (CDC).6 Appropriate antibiotic prescribing improves patient safety, slows development of antibiotic resistance, and reduces wasted resources.1
A better understanding of antibiotic use in US hospitals can inform stewardship efforts by identifying targets for reducing inappropriate or unnecessary prescribing. Previous national surveys of antibiotic usage in acute care hospitals were conducted in 20023,7,8 and 20119 by the CDC. Furthermore, several studies have capitalized on electronic or administrative data from US hospitals to characterize antibiotic use.10-16 However, past efforts have been limited by diversity in patient populations and facilities that precluded national estimates and provided limited longitudinal estimates. To address these gaps, we used a proprietary administrative data set from a large and diverse population of US hospitals to estimate patterns of inpatient antibiotic use over several years and extrapolate these findings to all US hospitals.
Adult and pediatric drug use data were obtained from the Truven Health MarketScan Hospital Drug Database (HDD). The HDD contains hospital discharge records for all patients discharged from participating acute care, general, nonfederal hospitals in the United States. These records include discharge-specific diagnostic and procedure codes, demographic information, inpatient drug usage data based on billing records, admission and discharge dates, and facility descriptors. We included visits from contributing hospitals for patients discharged from January 1, 2006, to December 31, 2012, including in-hospital deaths. For each discharge, we identified antibiotic doses charged to the patient during the inpatient stay. We searched the HDD for doses of any antibiotic listed in the US Food and Drug Administration’s National Drug Code Directory17 or the World Health Organization’s Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD) classification system.18 We eliminated antibiotics not administered by oral, parental, or inhalation routes. Each antibiotic was categorized into 1 of 15 classes: aminoglycoside, first- and second-generation cephalosporin, third- and fourth-generation cephalosporin, lincosamide, fluoroquinolone, macrolide, glycopeptide, sulfonamide, β-lactam/β-lactamase inhibitor combination, carbapenem, penicillin, tetracycline, metronidazole, and other antibacterial agents. We further eliminated hospitals not submitting any antibiotic usage data within a given year (2% of participating hospitals). This study did not require review by an investigational review board as the HDD contains no personally identifiable data, and the data use agreement precluded any access by the investigators to such identifiers; therefore, the analysis did not involve human subjects.
We retrospectively estimated measures of antibiotic use as both days of therapy per 1000 patient-days (DOT) and the proportion of hospital discharges in which a patient received at least 1 dose of an antibiotic during their stay. One DOT represents the administration of a single agent on a given day regardless of the dosage strength or number of doses. For example, administration of a single 1000-mg dose of cefazolin or 3 1000-mg doses given 8 hours apart both constitute 1 DOT, while a patient receiving doses of vancomycin and ceftazidime would count as 2 DOTs.10 In addition to calculating overall usage measures, we stratified measures by antibiotic class, year, or other patient and facility characteristics. All hospital locations were included.
To create national estimates of inpatient antibiotic use, we performed a weighted extrapolation of data from the subset of US hospitals reporting to the HDD. We generated estimated weights to apply to HDD data using data submitted to the Centers for Medicare and Medicaid Services Healthcare Cost Report Information System (HCRIS). The HCRIS includes reports submitted from all Medicare-certified US hospitals.19 We used the HCRIS to determine the number of patient-days and discharges among all US nonfederal acute care hospitals for each year of the study. Furthermore, we stratified by bed size (<300, ≥300), US census division, urban or rural status, and teaching status. In a similar fashion, we determined the number of patient-days and discharges for each hospital participating in the HDD by year, stratified by the same characteristics. To determine hospital-specific weights for the extrapolation, we divided year-specific total patient-days or discharges in each of the HCRIS strata by the number of patient-days or discharges for each participating HDD hospital to generate a hospital-specific weight. There were 72 possible strata based on these variables, but certain strata were combined due to the small number of participating hospitals in the HDD. As a result, 35 strata were created to generate weights. For the DOT measure, weights based on patient-days were used and further stratified by critical care days vs all other inpatient-days; for the proportion of discharges during which an antibiotic was used, weights based on discharges were used. Results are reported as the weighted national estimates except where otherwise noted.
To validate the extrapolated national estimates, we compared our national estimates based on the HDD with independent national estimates derived from the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (Agency for Healthcare Research and Quality, Rockville, Maryland; http://hcupnet.ahrq.gov/). Specifically, we compared results from our extrapolated national estimates with those of the HCUP with regard to the following: number of annual inpatient discharges and inpatient-days, the mean and median length of stay (LOS), age and sex distribution of discharged patients, payer distribution, distribution of certain common diagnostic and procedure codes, and proportion of inpatient deaths. Comparisons were limited to nonfederal hospitals in the HCUP because our weights were based on nonfederal hospitals and to the year 2012 for this report.
To assess potential trends in antibiotic use over time, we developed a multivariate model using linear regression based on the approximately normal distribution of the outcome. Our model used generalized estimating equations (GEE) to account for interhospital covariance. Our outcome was DOT per 1000 patient-days for each facility and used facility weights as described previously. Our main variable of interest was calendar year, and we included facility characteristics such as case mix index, average age, bed size category, teaching status, facility urban or rural location, proportion of surgical discharges, average comorbidity score for the facility,20 and facility geographic location as determined by US census division. Furthermore, we used revenue codes to identify days in which patients received care from intensive care units; for those days, antibiotic usage was attributed to a critical care location. For all other patient-days, antibiotic usage was attributed to a noncritical care location. We also included in the model the proportion of inpatient-days in which the primary International Classification of Diseases, Ninth Revision, Clinical Modification21 diagnosis code for that admission was related to an infection, which we previously found to be an important predictor of hospital antibiotic usage.22 To examine possible region-specific and age-specific trends, we included interaction terms between calendar year and census division or age category instead of average age.
All data were analyzed using SAS version 9.3 (SAS Institute Inc).
From January 1, 2006, to December 31, 2012, data on over 34 million discharges representing 166 million patient-days from 552 hospitals were included in the study. Over the 7 years, the number of hospitals contributing data for a given year ranged from 300 to 383 (Table 1). The proportion of hospitals varied by geographic location, with the largest number of hospitals participating in the South Atlantic region (29%) and the lowest in the New England region (3%); a distribution that was slightly but significantly different than that of all US hospitals. Hospitals were generally larger and more frequent in urban areas.
National estimates from our analysis were compared with those from the HCUP (Table 2). While patient-days and discharges among reporting hospitals decreased over time, the weighted national estimates of total patient-days and discharges were similar to those from the HCUP across study years, differing by −0.7% to 5.6% for any given year. In addition, our extrapolated estimates were similar to the HCUP estimates for median LOS, sex distribution, age categories, distribution of common diagnostic and procedure codes, and proportion of inpatient stays resulting in death. Estimates of the proportion of discharges with a private source primary payer was higher than the HCUP (38.8% vs 31.5%).
Overall, 55.1% of patients discharged received at least 1 dose of an antibiotic during their hospital visit. The overall rate of antibiotic use for all study years was 755 per 1000 patient-days (Table 3). Both the proportion of discharges during which an antibiotic was received and the DOT per 1000 patient-days varied by antibiotic class. Days of therapy per 1000 patient-days were highest for fluoroquinolones, third- and fourth-generation cephalosporins, and β-lactam/β-lactamase inhibitor combinations. The proportion of discharges in which an antibiotic was given during the hospital visit was highest for first- and second-generation cephalosporins, fluoroquinolones, and third- and fourth-generation cephalosporins.
The multivariable trend analysis of data from participating hospitals did not show a statistically significant change in overall use (total DOT increase, 5.6; 95% CI, −18.9 to 30.1; P = .65). Temporal trends varied by antibiotic class (Figure 1). Estimates of usage decreased for aminoglycosides, first and second generation cephalosporins, fluoroquinolones, sulfa, metronidazole (P < .001 for preceding medications), and penicillins (P = .01) with the greatest decrease among fluoroquinolones. Macrolides, third- and fourth-generation cephalosporins, glycopeptides, β-lactam/β-lactamase inhibitor combinations, carbapenems, tetracyclines, and other types of antibacterials all increased (P < .001 for all except third- and fourth-generation cephalosporins [P = .001]).
Usage of antibiotics was about 52% greater in critical care locations (1092 vs 720 DOT per 1000 patient-days) (Table 3) compared with noncritical care locations (P < .001) but not consistently for every class. Usage was significantly greater in critical care locations for aminoglycoside, third- and fourth-generation cephalosporin, glycopeptide, β-lactam/β-lactamase inhibitor combination, carbapenem, penicillin, metronidazole, and other types of antibacterials (eFigure 1 in the Supplement).
Antibiotic usage varied by geographic location of the hospital even after controlling for various facility characteristics in the multivariable model (P < .001) (Figure 2). Divisions in the Southeast Central, Northeast Central, Southwest Central, and Mountain areas of the United States had the highest DOT per 1000 patient-days overall, while divisions in the New England, Mid Atlantic, and Pacific had the lowest. Trends in usage over time did not vary significantly by geographic region (P = .25).
Antibiotic usage did not vary significantly by facility bed size (P = .17) or urban or rural location (P = .34). Based on our GEE model, hospitals identified as nonteaching had slightly higher DOT per 1000 patient-days compared with teaching hospitals (P = .004). Similarly hospitals denoted as large urban teaching hospitals had a lower but not significantly different DOT per 1000 patient-days compared with other hospitals (P = .16).
Antibiotic usage varied by age group. Usage was lowest for those younger than 18 years and highest for those 45 years and older. Among the youngest age group, aminoglycosides, third- and fourth-generation cephalosporin, and penicillin were the most commonly used antibiotics, while the most commonly used classes for older age groups were third- and fourth-generation cephalosporin, fluoroquinolones, glycopeptide, and β-lactam/β-lactamase inhibitor combinations. The distribution of usage by age group was consistent among census divisions, and usage over time did not vary significantly by age group in GEE models (P = .12).
Our study is the first, to our knowledge, to provide national estimates of temporal trends in antibiotic use among US hospitals. These observations build upon previous studies, including those from a recent national point-prevalence survey of inpatient antibiotic use,9 by demonstrating important changes in use over time and quantifying days of antibiotic therapy. While overall rates of antibiotic use in US hospitals did not change significantly from 2006 to 2012, we identified important trends within individual antibiotic classes. There were significant decreases in fluoroquinolones (20%) and first- and second-generation cephalosporins (7%) usage, but these decreases were offset by significant increases in vancomycin (32%) and agents with broad-spectrum activity against gram-negative bacteria, including carbapenem (37%), third- and fourth-generation cephalosporin (12%), and β-lactam/β-lactamase inhibitor combination antibiotics (26%). Despite substantial reduction in fluoroquinolone use, this class remained the most commonly used antibiotic class in US hospitals in 2012 (eFigure 2 in the Supplement).
We can only hypothesize why we observed certain antibiotic class-specific trends. For instance, the decrease in fluoroquinolone use may be related to Clostridium difficile infection prevention efforts23 or changes to empirical therapy due to the emergence of widespread resistance to fluoroquinolones among several clinically important bacteria.24 Increases in third- and fourth-generation cephalosporin, β-lactam/β-lactamase inhibitor combination, and carbapenem antibiotics may reflect increasing concern about infections caused by antibiotic-resistant gram-negative bacteria. Likewise, increases in glycopeptide use, mainly vancomycin, may reflect a response to the emergence of methicillin-resistant Staphylococcus aureus as a common cause of community-acquired skin and soft tissue infections.25,26
The current distribution of inpatient antibiotic use by antibiotic class in the United States appears to differ considerably in comparison to the United Kingdom and France. For example, in 2012, 47% of total inpatient use in the United States was accounted for by 4 classes: third- and fourth-generation cephalosporin, fluoroquinolone, carbapenem, and glycopeptide. In contrast, these 4 classes accounted for only 11% of inpatient use in the United Kingdom from 2012 to 201327 and for 27%, an estimate including all cephalosporins, in France in 2007.28 Similarly, penicillin antibiotics account for 30% of inpatient use in the United Kingdom27 and 21% in France28 but only 4% in US hospitals. It is possible that differences in prevalence of antibiotic-resistant pathogens observed in these countries, which tend to be lower than the United States, could be, in part, attributable to different patterns of antibiotic use, although other factors, such as different infection control practices or patient movement patterns may also play a role.25,29 Between 2005 and 2009, the United Kingdom observed dramatic reductions in C difficile infection, which is hypothesized to be attributable to replacing a large proportion of fluoroquinolone and cephalosporin use with antibiotics such as penicillin that may be less likely to result in C difficile overgrowth. Overall rates of antibiotic use in the United Kingdom did not change during this time period.30,31 While the optimal distribution of antibiotic use by class is unknown, the United Kingdom’s experience suggests a similar shift in distribution might be beneficial for US patients. Such a change is likely feasible given that approximately 50% of inpatient antibiotic use in US hospitals is for treatment of lower respiratory and urinary tract infections9 and that inpatient prescribing for these and other infections is often inappropriate.2,32 While current treatment guidelines for lower respiratory tract infections include fluoroquinolones or cephalosporins, nonfluoroquinolone and noncephalosporin regimens are also recommended as first-line therapy.33 Enhanced efforts to improve diagnosis of urinary tract infections could lead to deep reductions in unnecessary antibiotic use directed at urinary tract infections that are commonly treated with third-generation cephalosporin or fluoroquinolone antibiotics. A shift away from inpatient fluoroquinolone and cephalosporin use may have major implications for prevention of C difficile infections in the United States, especially because use of these 2 categories of antibiotics was particularly common among older patients at the highest risk of severe outcomes from C difficile infections.
Our study had a number of strengths. Of studies estimating inpatient antibiotic use in the United States, ours is the largest to date that we know of, containing information from at least 300 hospitals each year, representing a diversity of sizes, teaching status, and urban or rural locations in each geographic division. In addition, our study contained data across several years allowing for trend analysis. Even though our sample of hospitals contained a wider variety of hospital types, our point estimates were consistent with results from past studies with regard to overall and class-specific use.9-11,15 Detailed data contained information on a range of hospital and patient-specific demographic and clinical characteristics, allowing for this information to be included in multivariate models. Furthermore, we used data from the HCRIS to develop weighting information to extrapolate our estimates to the national level. Since nonweighted estimates were similar to those produced by our extrapolation, we believe the sample of hospitals participating in the HDD may represent a national sample. When we validated our national estimates from the HDD with independent national estimates derived from the HCUP, those measures matched well.
This study has certain limitations. Administrative data are collected primarily for billing purposes and adapted for research. There is likely misclassification in pharmacy, clinical, and facility information; however, this bias is most likely nondifferential. Furthermore, administrative data has been shown to be useful in other areas of health care research.34-38 Use of pharmacy charge data to estimate medication usage in hospitals was previously validated in a small sample with excellent agreement11 and more recently in a small group of pediatric hospitals.39 When limited to hospitals submitting data for at least 5 years of the study period, our analysis found similar trends in the multivariate analyses. Likewise, some geographic regions are over or under represented by the distribution of hospitals in this sample compared with the US distribution of hospitals. We sought to overcome this through regional adjustment of estimates using nationally representative data from the HCRIS; however, the small number of hospitals in some regions may still limit the reliability of the estimates. Furthermore, our extrapolated estimates were limited to acute, nonfederal hospitals in the United States and do not adequately represent children’s hospitals, which represent less than 1% of included hospitals. Nonetheless, we were encouraged to find that in aggregate, our national estimates appear quite consistent with other studies. Finally, due to changes in the data source, we were unable to generate national estimates after 2012; however, we do not believe major changes in antibiotic use in acute care hospitals have occurred. In a sensitivity analysis including a sample of 137 hospitals with data through 2014, we observed similar trends. Unfortunately, the hospitals available for this analysis were not representative of the entire sample because not all geographic regions were represented in this limited sample of hospitals.
Overall rates of antibiotic use in US hospitals did not change significantly from 2006 to 2012. However, we identified significant changes in specific antibiotic classes and regional variation that may have important implications for reducing antibiotic-resistant infections. Improved monitoring of antibiotic use is critical to direct the work of antibiotic stewardship programs in the United States. In 2012, the CDC launched the Antibiotic Use Option of the National Healthcare Safety Network that provides real-time monitoring of antibiotics administered in US hospitals. As enrollment in the antibiotic use option grows, it will provide ongoing systematic assessment at the hospital, state, regional, and national levels. Because inappropriate antibiotic use increases the risk of antibiotic resistance and other adverse patient outcomes,2 continued monitoring of antibiotic use is critical to future improvements in patient safety.
Corresponding Author: James Baggs, PhD, 1600 Clifton Rd, MS: A31, Atlanta, GA 30333 (email@example.com).
Published Online: September 19, 2016. doi:10.1001/jamainternmed.2016.5651
Author Contributions: Dr Baggs had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: All Authors.
Acquisition, analysis, or interpretation of data: Baggs, Fridkin, Pollack, Jernigan.
Drafting of the manuscript: Baggs, Jernigan.
Critical revision of the manuscript for important intellectual content: All Authors.
Statistical analysis: Baggs.
Administrative, technical, or material support: Pollack, Jernigan.
Study supervision: Fridkin, Jernigan.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was funded by the Centers for Disease Control and Prevention (CDC).
Role of the Funder/Sponsor: This manuscript underwent the CDC clearance process, but otherwise the CDC had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.