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The FAVOURED trial (Fish Oils and Aspirin in Vascular Access Outcomes in Renal Disease) is the first randomized clinical trial to determine whether fish oil or low-dose aspirin is effective in preventing failure of de novo arteriovenous fistulae (AVF) in patients requiring hemodialysis. In this trial that included 567 adults, the occurrence of fistula failure within 12 months of surgery was high (47%) and not reduced by fish oil (relative risk 1.03) or aspirin (relative risk 1.05) compared with placebo. Based on these results, neither fish oil nor aspirin can be recommended for prevention of AVF failure and additional strategies to reduce the high AVF failure rate are urgently required.
Highlights. JAMA Intern Med. 2017;177(2):151–153. doi:10.1001/jamainternmed.2016.6129
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