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Auer R, Concha-Lozano N, Jacot-Sadowski I, Cornuz J, Berthet A. Heat-Not-Burn Tobacco Cigarettes: Smoke by Any Other Name. JAMA Intern Med. 2017;177(7):1050–1052. doi:10.1001/jamainternmed.2017.1419
The tobacco industry’s most recent response to the documented harms of cigarette smoking was to launch new heat-not-burn (HNB) tobacco cigarettes.1 Philip Morris International (PMI) created IQOS (I-Quit-Ordinary-Smoking): disposable tobacco sticks soaked in propylene glycol, which are inserted in a holder in the HNB cigarette. The tobacco is heated with an electric blade at 350°C. The cigarettes are marketed by PMI as a “revolutionary technology that heats tobacco without burning it, giving you the true taste of tobacco, with no smoke, no ash and less smell.”2 In many countries, laws that protect people from passive smoke only apply to smoked tobacco products. Philip Morris International claims that IQOS releases no smoke because the tobacco does not combust and the tobacco leaves are only heated not burned. However, there can be smoke without fire. The harmful components of tobacco cigarette smoke are products of incomplete combustion (pyrolysis) and the degradation of tobacco cigarettes through heat (thermogenic degradation). Complete combustion occurs at a high temperature (>1300°C), higher than the heat generated by smoking a tobacco cigarette (<800°C). Typical markers of pyrolysis and thermogenic degradation of tobacco cigarettes are acetaldehyde, an irritant carcinogenic volatile organic compound, benzo[a]pyrene, a carcinogenic polycyclic aromatic hydrocarbon, and carbon monoxide.
Pilot programs for IQOS began in 2014 in Japan and in 2015 in Switzerland and Italy. An internet survey in Japan published in 2015 suggested that younger individuals (15 to 39 years of age) were more likely to use IQOS, as were former smokers and current smokers.3 Since 2016, a total of 19 countries have allowed the sale of IQOS cigarettes. In June 2016, data from PMI revealed that IQOS had captured 2.2% of the cigarette market in Japan. IQOS is not yet sold in the United States, but in December 2016, PMI submitted a modified risk tobacco product application to the US Food and Drug Administration. If successful, PMI will be less restricted in its marketing for the IQOS than for conventional tobacco cigarettes. Smokers and nonsmokers need accurate information about toxic compounds released in IQOS smoke. This information should come from sources independent of the tobacco industry, but the only analyses we found were from PMI and PMI competitors.1
We compared the contents of IQOS (IQOS Holder, IQOS Pocket Charger, Marlboro HeatSticks [regular], and Heets, Philipp Morris SA) smoke with the contents of conventional cigarettes (Lucky Strike Blue Lights). We used a smoking device designed and tested in our facility to capture the mainstream aerosol and developed to meet standards for common cigarettes and e-cigarettes.4 We followed the International Organization for Standardization standards for puff volume (35 mL) at 2 puffs per minute, based on observation of IQOS smokers, who took a mean of 14 puffs during 5 to 6 minutes. We analyzed volatile organic compounds and nicotine by gas chromatography coupled to a flame ionization detector and polycyclic aromatic hydrocarbons using high-performance liquid chromatography coupled to a fluorescence detector, as previously described.4 We trapped polycyclic aromatic hydrocarbons from IQOS cigarette smoke in a glass filter (Whatman 37 mm Ø GF/B) mounted in line with an XAD2 cartridge. For each sampling, 10 IQOS cigarettes were smoked. Each sampling support was desorbed in 10 mL of acetonitrile and sonicated for 1 hour. The eluate was evaporated in a vacuum concentrator (Speed Vac SC-200, ThermoFisher Scientific) set with 30 millibars and 27g until the residue was almost dry to prevent evaporation of the most volatile polycyclic aromatic hydrocarbons. The residue was filtered with polytetrafluoroethylene membrane (Acrodisc CR 13 mm, 0.45 µm, Pall Life Sciences) before it was analyzed with a high-performance liquid chromatography device (Ultimate 3000, ThermoFisher Scientific) equipped with a fluorescence detector (FLD-3000RS), UV detector (VWD-3000), and a separation column Nucleodur EC 150 × 3 mm C18 3 µm (Macherey-Nagel) under isocratic conditions (1.2 mL · min−1). We injected 2 µL into the high-performance liquid chromatography chain; methanol/water (70/30) with acetonitrile was the eluent solvent at an initial ratio of 100% to 0% (4 minutes) and a linear gradient up to 100% acetonitrile (12 minutes). We did not analyze polycyclic aromatic hydrocarbons generated by conventional cigarettes and present the mean values in the 35 best-selling cigarettes brands in the United States, as reported by Vu et al.5 We monitored the temperature near the heater blade inside the IQOS holder and the core of the conventional cigarette at a sampling rate of 3 Hz with a type k thermocouple.
Volatile organic compounds, polycyclic aromatic hydrocarbons, and carbon monoxide were present in IQOS smoke (Table). The temperature of the IQOS was lower (330°C) than the conventional cigarette (684°C).5 The IQOS smoke had 84% of the nicotine found in conventional cigarette smoke.
The smoke released by IQOS contains elements from pyrolysis and thermogenic degradation that are the same harmful constituents of conventional tobacco cigarette smoke. International experts were invited by PMI to describe the IQOS aerosol; one expert claims that “less than 2% by weight of the aerosol components may derive from the pyrolysis of the tobacco substrate which would not be sufficient to characterize the aerosol as ‘smoke.’”6(p 2) In contrast, our analyses reveal that advertising slogans such as “heat-not-burn” are no substitute for science. Dancing around the definition of smoke to avoid indoor-smoking bans is unethical. Principle 1 for implementing article 8 of the World Health Organization convention on tobacco control highlights that we should reject ideas that there is a threshold value for toxic effects from second-hand smoke. Independent studies should further evaluate the health effects of the IQOS. In the meantime, heated tobacco products such as IQOS should fall under the same indoor-smoking bans as for conventional tobacco cigarettes.
Corresponding Author: Reto Auer, MD, MAS, Institute of Primary Health Care (BIHAM), University of Bern, Gesellschaftsstrasse 49, 3012 Bern, Switzerland (email@example.com).
Accepted for Publication: March 15, 2017.
Published Online: May 22, 2017. doi:10.1001/jamainternmed.2017.1419
Author Contributions: Drs Auer and Berthet had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Auer, Concha-Lozano, Jacot-Sadowski, Berthet.
Acquisition, analysis, or interpretation of data: Auer, Concha-Lozano, Jacot-Sadowski, Cornuz, Berthet.
Drafting of the manuscript: Auer, Concha-Lozano, Berthet.
Critical revision of the manuscript for important intellectual content: Concha-Lozano, Jacot-Sadowski, Cornuz.
Statistical analysis: Concha-Lozano.
Obtained funding: Cornuz, Berthet.
Administrative, technical, or material support: Concha-Lozano, Berthet
Conflict of Interest Disclosures: None reported.
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