Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products | Oncology | JAMA Internal Medicine | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
National Toxicology Program.  Toxicology and carcinogenesis studies of pulegone (CAS No. 89-82-7) in F344/N rats and B6C3F1 mice (gavage studies).  Natl Toxicol Program Tech Rep Ser. 2011;(563):1-201.PubMedGoogle Scholar
 Synthetic flavoring agents and adjuvants.  Fed Regist. 2018;83(195):50490-50503.Google Scholar
Lisko  JG, Tran  H, Stanfill  SB, Blount  BC, Watson  CH.  Chemical composition and evaluation of nicotine, tobacco alkaloids, pH, and selected flavors in e-cigarette cartridges and refill solutions.  Nicotine Tob Res. 2015;17(10):1270-1278. doi:10.1093/ntr/ntu279PubMedGoogle ScholarCrossref
Lisko  JG, Stanfill  SB, Watson  CH.  Quantitation of ten flavor compounds in unburned tobacco products.  Anal Methods. 2014;6(13):4698-4704. doi:10.1039/C4AY00271GPubMedGoogle ScholarCrossref
Stanfill  SB, Ashley  DL.  Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry.  J Chromatogr A. 1999;858(1):79-89. doi:10.1016/S0021-9673(99)00796-7PubMedGoogle ScholarCrossref
Schröder  K, Escher  SE, Hoffmann-Dörr  S, Kühne  R, Simetska  N, Mangelsdorf  I.  Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose.  Toxicol Lett. 2016;261:32-40. doi:10.1016/j.toxlet.2016.08.013PubMedGoogle ScholarCrossref
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    Research Letter
    September 16, 2019

    Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products

    Author Affiliations
    • 1Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina
    JAMA Intern Med. 2019;179(12):1721-1723. doi:10.1001/jamainternmed.2019.3649