There were no cases reported during the week of July 7 through 13, 2020. EVALI indicates e-cigarette, or vaping, product use–associated lung injury.
eFigure 1. California Department of Public Health case definition for e-cigarette, or vaping, product use-associated lung injury (EVALI)
eMethods. Detailed laboratory methods for analysis of case-patient vaping materials
eTable 1. Number of patients with product types identified by laboratory testing
eTable 2. Patient product types and diluents identified by laboratory testing.
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Heinzerling A, Armatas C, Karmarkar E, et al. Severe Lung Injury Associated With Use of e-Cigarette, or Vaping, Products—California, 2019. JAMA Intern Med. 2020;180(6):861–869. doi:10.1001/jamainternmed.2020.0664
What are the clinical characteristics and vaping exposures among patients hospitalized with e-cigarette, or vaping, product use–associated lung injury (EVALI) in California?
Of 160 patients included in this case series, 74% were younger than 35 years, 46% required admission to intensive care units, and 29% required mechanical ventilation. Of 86 patients interviewed, 83% reported using tetrahydrocannabinol (THC)-containing products, most of which were acquired from informal sources; vitamin E or vitamin E acetate was present in 84% of THC-containing products tested from 24 patients.
Use of THC-containing products and vitamin E acetate appear to be associated with the EVALI outbreak, but additional investigation is needed to determine the cause(s).
Since August 2019, more than 2700 patients have been hospitalized with e-cigarette, or vaping, product use–associated lung injury (EVALI) across the United States. This report describes the outbreak in California, a state with one of the highest case counts and with a legal adult-use (recreational) cannabis market.
To present clinical characteristics and vaping product exposures of patients with EVALI in California.
Design, Setting, and Participants
Case series describing epidemiologic and laboratory data from 160 hospitalized patients with EVALI reported to the California Department of Public Health by local health departments, who received reports from treating clinicians, from August 7 through November 8, 2019.
Standardized patient interviews were conducted to assess vaping products used, frequency of use, and method of product acquisition. Vaping products provided by a subset of patients were tested for active ingredients and other substances.
Main Outcomes and Measures
Demographic and clinical characteristics, level of care, and outcomes of hospitalization were obtained from medical record review.
Among 160 patients with EVALI, 99 (62%) were male, and the median age was 27 years (range, 14-70 years). Of 156 patients with data available, 71 (46%) were admitted to an intensive care unit, and 46 (29%) required mechanical ventilation. Four in-hospital deaths occurred. Of 86 patients interviewed, 71 (83%) reported vaping tetrahydrocannabinol (THC)-containing products, 36 (43%) cannabidiol (CBD)-containing products, and 39 (47%) nicotine-containing products. Sixty-five of 87 (75%) THC-containing products were reported as obtained from informal sources, such as friends, acquaintances, or unlicensed retailers. Of 87 vaping products tested from 24 patients, 49 (56%) contained THC. Vitamin E or vitamin E acetate was found in 41 (84%) of the THC-containing products and no nicotine products.
Conclusions and Relevance
Patients’ clinical outcomes and vaping behaviors, including predominant use of THC-containing products from informal sources, are similar to those reported by other states, despite California’s legal recreational cannabis market. While most THC products tested contained vitamin E or vitamin E acetate, other underlying cause(s) of injury remain possible. The California Department of Public Health recommends that individuals refrain from using any vaping or e-cigarette products, particularly THC-containing products from informal sources, while this investigation is ongoing.
Vaping, or electronic cigarette (e-cigarette) use, has grown substantially in the United States in recent years, particularly among youth.1,2 Vaping devices heat liquids to generate an aerosol that is inhaled into the lungs, and liquids can contain active ingredients such as nicotine; cannabis-derived compounds including tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, and cannabidiol (CBD); as well as flavorings and other chemicals.3 Despite increases in vaping among youth, the contents of vaping products are largely unregulated nationally. Recreational cannabis use, including the sale of cannabis-containing vaping products, is legal in California for adults 21 years and older under the Adult Use of Marijuana Act (Proposition 64), though local jurisdictions can prohibit or regulate cannabis sales.
On August 7, 2019, a local health department notified the California Department of Public Health (CDPH) of a cluster of 7 previously healthy individuals who were hospitalized with severe lung injury without evidence of infection. All reported a history of vaping. These reported cases closely resembled those described in a Wisconsin alert issued on July 25, 2019.4 On August 9, 2019, CDPH issued a statewide health alert to clinicians and local health departments requesting reports of any suspected cases of e-cigarette, or vaping, product use–associated lung injury (EVALI).
As of January 2020, more than 2700 EVALI cases have been reported in all 50 states.5 Investigations in other states and nationally have described EVALI and highlighted the role of THC-containing products from informal sources6-8; however, findings from a state with a legal adult-use cannabis market have not previously been reported. This report describes demographics, clinical characteristics, and vaping exposures of 160 patients reported to CDPH from August 7 through November 8, 2019, and initial results of laboratory testing of vaping products used by case patients to help direct the public health response to the outbreak and guide clinicians caring for patients with EVALI.
Clinicians or hospitals reported suspected cases of EVALI to local health departments, who then reported them to CDPH. CDPH clinicians classified cases using a case definition based on the one established by the Centers for Disease Control and Prevention (CDC), which requires vaping in the past 90 days, findings of infiltrates or opacities on chest imaging, and absence of other plausible clinical explanations for illness, including infectious causes,6 with the additional requirement in California of hospitalization (see eFigure in the Supplement for full case definition). The California EVALI case definition was restricted to hospitalized patients in order to improve specificity while capturing the most severe cases. Although CDC’s case definition does not include this requirement, 95% of case patients reported nationally have been hospitalized, and since November 2019, CDC has only accepted reports of hospitalized cases.5
From August 7 through November 8, 2019, 160 cases of EVALI were reported to CDPH. At the time of initial case report, CDPH collected patient age, sex, and basic clinical information, including intensive care unit (ICU) admission and mechanical ventilation. CDPH clinicians reviewed and abstracted medical records for 106 patients (66%) with complete records available to gather data on additional clinical variables.
Local health department staff interviewed 86 patients (54%) or their family members in person or by telephone using a standardized questionnaire developed by CDPH in consultation with other states and the CDC. Patients were asked to report each type of product used, including different brands, flavors, and active ingredients, as a unique product. For each unique vaping product used, interviewed patients were asked to report product information such as active ingredient, frequency of use, and method of product acquisition. Specific locations of product acquisition named in patient interviews were compared with the California Bureau of Cannabis Control (BCC) License Search database.9
We calculated P values for categorical variables using Pearson χ2 tests, or 2-sided Fisher exact tests for cells with small values, and t tests for continuous variables. Analyses were conducted using SAS, version 9.4 (SAS Institute). We considered P values less than .05 to be statistically significant.
Vaping materials, including cartridges, pods, oils, and devices, were collected from patients voluntarily by local health jurisdictions; some patients declined to provide products or no longer had products available. Samples with sufficient residual liquid were tested by CDPH, and a subset tested by a partner state public health laboratory, in the order received by CDPH. Gas- and liquid-chromatography with mass spectrometry were performed to screen for THC, CBD and other cannabinoids, nicotine, vitamin E (alpha tocopherol; VE) and vitamin E acetate (alpha tocopheryl acetate, an esterified form of vitamin E; VEA), pesticides, synthetic cannabinoids, opioids, and other nontargeted compounds. Total reflection x-ray fluorescence was used to screen for metals (see eMethods in the Supplement for methodological details).
The California Health and Human Services Agency’s Committee for the Protection of Human Subjects determined that this investigation was exempt from review, as well as waived the need for patient informed consent, because the content involved public health practice, not research.
Among 160 patients with EVALI, the median age was 27 years (range, 14-70 years), and 99 (62%) were male (Table 1). Patients were admitted to the hospital between June 18 and November 6, 2019 (Figure). Among 86 patients interviewed, 38 (46%) were non-Hispanic white, and 39 (47%) were Hispanic. Race and ethnicity were only available for interviewed patients and based on their self-report, with categories selected by the investigators with the options of other and declines response available. There were no statistically significant differences in age or sex among interviewed and noninterviewed patients.
Among 86 patients interviewed, 71 (83%) reported vaping THC-containing products, and 27 (31%) reported exclusive use of THC products (Table 1). Nearly half (39 [47%]) reported using nicotine-containing vaping or e-cigarette products, and 8 (9%) reported exclusive use. Some (36 [43%]) reported using a CBD-containing product, and 4 (5%) reported exclusive use. One patient reported exclusive use of a flavor-only vaping product that did not contain THC, CBD, or nicotine. Most (63 [73%]) reported vaping at least daily, and 30 (35%) reported vaping 5 or more times daily.
The 86 interviewed patients reported using 130 (range, 1-5 per individual) unique vaping products in the 90 days prior to EVALI symptom onset (Table 2). Among 87 products reported to contain only THC, 79 (91%) were prefilled cartridges, while among 25 nicotine-only products, only 12 (48%) were prefilled cartridges. Forty-five of the 87 (56%) THC-containing products and 19 of the 25 (76%) nicotine-containing products reportedly contained flavoring.
Nicotine-containing products were most commonly reported as purchased at vape shops or dispensaries (11 of 25 [44%]) or bought or received from another person (7 of 25 [28%]); THC-containing products were most commonly bought or received from another person (38 of 87 [44%]) or purchased at a vape shop or dispensary (28 of 87 [33%]). When asked specifically whether THC-containing products had been acquired at a licensed dispensary, patients answered affirmatively for only 22 of 87 (25%) THC-containing products, which represent a subset of the 28 products reported as purchased at vape shops or dispensaries (Table 2). Of the 22 products, only 4 products, belonging to 1 patient, had a named purchase location verified as a licensed dispensary in the BCC database. The remaining 18 (82%) products were either reported as acquired from a pop-up shop or from another individual (5 products), acquired from a named establishment that was not listed as licensed in the BCC database (4 products), or did not have a named purchase location that could be searched in the BCC database (9 products).
Among the 86 interviewed patients, median time from last vaping product use to EVALI symptom onset and to hospital admission was 3 days (range, 0-73 days) and 5 days (range, 0-87 days), respectively. Thirty-four of 79 patients (43%) reported continued vaping after symptom onset; 6 (8%) reported continued vaping after hospital admission.
Among all 160 patients, median time from symptom onset to hospital admission was 5 days (range, 0-30 days). Among 106 patients with complete medical records available, 69 (65%) sought outpatient or emergency medical care at least once prior to hospital admission, and 44 (42%) had been prescribed antibiotics or antivirals as an outpatient (Table 3). Additionally, 41 (39%) patients had a documented diagnosis of anxiety or depression, and 15 (14%) had a history of asthma. A total of 45 (42%) patients reported either current or former combustible tobacco smoking.
Of the 106 patients with complete medical records available, the most commonly reported symptoms were cough (89 [84%]), shortness of breath (87 [82%]), and subjective fever or chills (80 [76%]). Eighty-four (79%) patients reported at least 1 gastrointestinal symptom (Table 3). At admission, 98 (93%) patients met at least 2 systemic inflammatory response syndrome criteria. Of 85 patients tested, 17 (20%) had lactic acid greater than 2 mmol/L, and of 70 patients tested, 33 (47%) had procalcitonin greater than 0.5 ng/mL. Bilateral findings of infiltrates or opacities were observed on chest imaging in 100 of 106 (94%) patients.
Nearly all patients (104 of 106 [98%]) were treated with antibiotics during their hospital admission. Eighty-five of 106 (80%) patients received systemic steroids; of those who received steroids, 58 (68%) had documented clinical improvement. Fifteen of 106 (14%) patients were discharged from the hospital on supplemental oxygen. Four of 160 patients (3%), who were between the ages of 40 and 65 years, died in the hospital.
Among 156 patients with available data, 71 (46%) required admission to an ICU during their hospitalization, including 34 of 60 (57%) females and 37 of 95 (38%) males (P = .03). Of 154 patients with available data, 46 (29%) required mechanical ventilation. Among the 106 patients with complete medical records, 78 (74%) required some form of respiratory support (mechanical ventilation, positive airway pressure, high-flow oxygen, and/or oxygen via nasal cannula), and median length of hospitalization was 6 days (range, 1-37 days). There were no other statistically significant associations among ICU admission, mechanical ventilation, or length of hospitalization and age, reported substances vaped, or vaping frequency (Table 4). There were no statistically significant differences in mechanical ventilation or ICU admission between interviewed and noninterviewed patients.
Chemical analyses were performed on a total of 87 vaping products from 24 patients. Forty-nine products (56%) contained cannabis-derived compounds and 38 (44%) contained nicotine. All cannabis-containing products contained THC; 24 also contained CBD. No products contained both THC and nicotine, and no products contained CBD exclusively. Of the 24 patients with tested products, 20 submitted at least 1 product containing THC, 8 submitted at least 1 product containing nicotine, and 4 submitted both (eTable 1 in the Supplement).
In the 49 THC-containing products, VE and/or VEA was found in 41 (84%), which corresponds to 16 patients with VE and/or VEA products in the 20 (80%) patients who submitted THC-containing products. Of 41 products with either VE or VEA, 32 contained both substances, 2 contained VEA only, and 7 contained VE only. VEA concentrations measured in 13 samples by the partner state laboratory ranged from 37% to 64%. No nicotine-containing products were found to contain VE or VEA. Propylene glycol was found in 34 of 38 (89%) nicotine-containing products and no THC-containing products (eTable 2 in the Supplement).
Ten vaping product liquids were screened for metals. Levels of arsenic, cadmium, chromium, mercury, manganese, and lead were below 100 parts per billion. Nickel was detected in 1 product.
Low levels of pesticides were found in 12 of 18 (67%) THC-containing products tested by a partner state laboratory for these substances. Detected pesticides included myclobutanil, bifenthrin, bifenazate, tebuconazole, metalaxyl, propiconazole, imidacloprid-urea, piperonyl butoxide, and trifloxystrobin. No synthetic cannabinoids or opioids were found in 27 products tested for these substances.
This report—the first to our knowledge to describe cases in a state with a legal adult-use (recreational) cannabis market—appears to confirm patterns of clinical findings and vaping practices previously reported in other states and nationally.6,10,11 Although California has a legal adult-use cannabis market, the majority of affected patients reported using THC-containing products obtained from informal sources, such as friends or acquaintances or unlicensed retailers. In addition, most THC-containing products tested contained VEA, which has recently been identified in both clinical and product samples from patients with EVALI.
Consistent with previous reports,6,10,11 in California, EVALI affected predominantly young, otherwise healthy patients, many of whom presented with both respiratory and gastrointestinal symptoms, and ultimately developed severe illness requiring ICU admission and mechanical ventilation. In addition, many patients sought care from outpatient or other health care providers at least once prior to hospitalization. The findings of this case series suggest that many patients with EVALI present with a severe inflammatory response, including signs, symptoms, and laboratory findings often presumed to be infectious by both outpatient and inpatient health care providers. These findings underscore the importance for all clinicians, including outpatient health care providers, to consider EVALI in patients with a history of vaping who present with typical findings of infection, as well as monitor their clinical course and respiratory status closely for decompensation, in accordance with CDC guidance.12 Clinicians should also continue to report suspected cases to local health departments to allow for ongoing public health surveillance and intervention. The high proportion of patients who improved clinically with systemic steroids suggests that steroid therapy may be beneficial, though additional research is needed to determine which patients may benefit most and which therapeutic regimens may be appropriate.12,13
Although the majority of patients with EVALI were male, we found that a higher proportion of female patients required ICU admission compared with male patients. Although this comparison was not adjusted for other potentially confounding variables, studies of other lung diseases have also suggested that women may be more susceptible to the effects of certain environmental insults, such as tobacco smoke.14
The most common preexisting comorbidities among California patients with EVALI were depression and anxiety, which is consistent with reports from other states.6,10,15 These findings may indicate higher vaping rates in patients with these conditions and/or increased risk of EVALI in these individuals. Although it has been suggested that use of nicotine e-cigarettes may be associated with certain mental health diagnoses,16 further research is needed to understand the link between depression and anxiety and EVALI.
In addition to the respiratory support required during hospitalization, 14% of patients required supplemental oxygen at time of hospital discharge. While limited short-term follow-up of patients with EVALI has shown persistent postdischarge symptoms and pulmonary function abnormalities,10,17 little is known about the potential long-term consequences of EVALI, such as sustained deficits in pulmonary function. Continued follow-up and investigation of clinical outcomes in affected patients is needed to answer these questions.
Overall, patient demographic and product-use patterns reported here are similar to those reported among patients in other states where cannabis use is illegal.15,18 The proportion of Hispanic patients in California (47%) is higher than nationally (16%); though this may reflect demographic differences in the overall population, it also highlights the need for additional investigation regarding vaping practices among different demographic groups.
Most patients interviewed (73%) reported vaping at least daily, and 35% reported vaping 5 or more times daily. Prior reports have suggested that higher frequency of vaping THC products may be associated with increased risk of EVALI.7 However, among affected patients in California there was no statistically significant association between vaping frequency and ICU admission or mechanical ventilation.
While most California patients reported vaping THC-containing products obtained from informal sources, some denied use of THC-containing vaping products. Recent findings from Illinois suggest that patients with EVALI who only vaped nicotine may differ in their demographics and clinical presentations from patients using THC-containing products, which potentially suggests a different contributing cause of injury.19 This subgroup of patients merits additional investigation, both in California and nationally.
Although cannabis products can be obtained from licensed dispensaries in some California municipalities, most patients with EVALI reported obtaining products from informal sources, which may not have performed state-mandated product testing. Among all adults in California who report vaping cannabis products, 76% reported stores or dispensaries as their usual product sources20; by comparison, patients with EVALI reported purchasing only 34% of THC products from vape shops or dispensaries. In addition, even among patients with EVALI who reported obtaining products from licensed dispensaries, most did not, in fact, name licensed purchase locations. More research about the factors influencing consumers’ choice of THC products, and education about where to safely obtain legal cannabis products, are needed to limit the use of potentially hazardous products from informal sources.
Although histopathologic findings from patients with EVALI have suggested airway-centered chemical pneumonitis,21,22 this pattern can represent a nonspecific response to a wide variety of toxicants. Recently, attention has focused on VEA, an esterified form of VE that is typically ingested as a dietary supplement or applied to the skin in cosmetic products. VEA was identified in the majority of patients’ THC-containing products tested by CDPH, other states, and the US Food and Drug Administration.8,15,23,24 In addition, CDC detected VEA in 94% of bronchoalveolar lavage specimens from patients with EVALI that were tested from multiple states, including California.25 Furthermore, in Minnesota, none of 7 tested THC-containing vaping products seized by law enforcement in 2018 were found to contain VEA, whereas all 20 seized in September 2019 did contain VEA, which supports a temporal association between the introduction of VEA into the market and the EVALI outbreak.8
Beyond VEA, a wide range of possible etiologic agents has been proposed, including other diluents, metals, pesticides, flavorings, and microbial products, though none has been identified consistently in laboratory testing to date. CDPH identified a subset of THC-containing products with VE but not VEA; neither VE nor VEA were found in any nicotine-containing products. Although propylene glycol, a common diluent for nicotine-based e-cigarettes, was found in most nicotine-containing products in California, it was not found in any THC-containing products. Furthermore, levels of metals, pesticides, synthetic cannabinoids, and opioids in patient products tested by CDPH were low or below detection limits.
Before the EVALI outbreak, VEA was not a recognized nor suspected inhalational toxicant. Indeed, 1 animal study using aerosolized VEA did not report any toxic effects to the lungs at the dose used.26 However, lung injuries from inhalation of compounds thought to be safe via other routes, such as butter flavorings, textile dye, and humidifier biocide, have been described.27,28 Surfactant disruption and generation of ketene, a highly reactive respiratory toxicant, have been invoked as biologically plausible mechanisms of VEA lung toxic effects.25 It is also possible that other known or novel toxicants could be generated during VEA vaporization, perhaps because of reactions with other fluid constituents or vaping device components.
This report is subject to several limitations. First, self-reporting of vaping practices may result in exposure misclassification because individuals may be unsure of the contents of their vaping products or may be hesitant to report use of products from informal sources. Second, only 54% of patients were interviewed; although age, sex, and disease severity of interviewed and noninterviewed patients were similar, the 2 groups may differ in other important ways. Product testing results were only available for a small sample of patients, and those patients may not have submitted all of their vaping products.
EVALI is a severe illness that continues to affect mostly young, otherwise healthy patients, with as yet undetermined long-term health effects. In this report, most patients in California reported using THC-containing products from informal sources, which suggests that individuals may continue to use unregulated products even in jurisdictions with licensed markets. Outreach by clinicians and public health departments is needed to educate patients and the public about the health risks associated with vaping, particularly vaping of unregulated cannabis products.
In addition, most THC-containing products tested in California contained VEA, which reinforces the potential association between this chemical and EVALI that has been suggested by prior studies of patient and product samples. However, additional research is needed to address the many unknowns still associated with this outbreak. Although most patients reported using THC-containing products, other potential causes of illness cannot be excluded at this time, particularly given the subset of patients in California and nationally who do not report use of THC-containing products. Therefore, while this investigation is ongoing, CDPH urges that individuals refrain from e-cigarette use and vaping of all substances, particularly THC-containing products from unregulated sources.29
Accepted for Publication: February 14, 2020.
Corresponding Authors: Jason A. Wilken, PhD, MPH, California Department of Public Health, 850 Marina Bay Pkwy, Building P, Third Floor, Richmond, CA 94804 (firstname.lastname@example.org); Christina Armatas, MD, MPH, California Department of Public Health, 850 Marina Bay Pkwy, Building P, Third Floor, Richmond, CA 94804 (email@example.com).
Published Online: March 6, 2020. doi:10.1001/jamainternmed.2020.0664
Author Contributions: Dr Heinzerling had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Heinzerling and Armatas contributed equally to this report.
Study concept and design: Heinzerling, Armatas, Karmarkar, Attfield, Vrdoljak, Wagner, Dean, Cummings, Wilken.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Heinzerling, Armatas, Karmarkar, Attfield, Guo, Vrdoljak, Moezzi, Wagner, Cummings, Wilken.
Critical revision of the manuscript for important intellectual content: Heinzerling, Armatas, Karmarkar, Wang, Vrdoljak, Moezzi, Xu, Wagner, Fowles, Dean, Cummings, Wilken.
Statistical analysis: Heinzerling, Armatas, Karmarkar, Attfield, Vrdoljak, Xu, Wagner.
Obtained funding: Vrdoljak.
Administrative, technical, or material support: Armatas, Attfield, Guo, Wang, Vrdoljak, Moezzi, Xu, Wagner, Fowles, Dean, Wilken.
Study supervision: Heinzerling, Armatas, Karmarkar, Vrdoljak, Dean, Wilken.
Conflict of Interest Disclosures: None reported.
Disclaimer: The findings and conclusions in this article are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the California Department of Public Health.
Additional Contributions: The authors gratefully acknowledge the Laboratory of Organic Analytical Chemistry at the Wadsworth Center of the New York State Department of Health for numerous chemical analyses provided for this study. The authors also acknowledge the following collaborators from local health departments in California for case identification and interviewing and collaborators at the California Department of Public Health for their contributions to the investigation logistics, public messaging, and laboratory work. e-Cigarette, or vaping, product–use associated lung injury investigators at local health departments include Elaine Bautista, Alameda County Public Health Department; Abigail Miranda, Contra Costa Public Health; Grinnell Norton, Glenn County Health and Human Services Agency; Jasmine Ochoa, Kern County Public Health Services Department; Sharon Soong, Kings County Department of Public Health; Emily Holman, Long Beach Department of Health and Human Services; Lello Tesema, Los Angeles County Department of Public Health; Jennifer Maddox, Madera County Department of Public Health; Matthew Willis, Marin County Department of Public Health; Kristy Michie, Monterey County Health Department; Eva Weinstein, Napa County Public Health; Alissa Dratch, Orange County Health Care Agency; Lorene Vanzandt, Placer County Health and Human Services; Barbara Cole, Riverside University Health System Public Health; Pamela Abdali, Sacramento County Public Health; Ruchi Pancholy, San Bernardino County Department of Public Health; Meagan Chuey, Epidemic Intelligence Service, Centers of Disease Control and Prevention, and County of San Diego Health and Human Services Agency; Kismet Baldwin, San Joaquin County Public Health Services; the San Mateo County Health Epidemiology Program; Karen White, Santa Barbara County Public Health Department; Rebecca Quenelle, County of Santa Clara Public Health Department; Rodney Butterfield, Solano Public Health; Denise Sanford, Stanislaus County Public Health; Katherina Martin, Tehama County Health Services Agency; Paula Ptomey, Tulare County Health & Human Services Agency; Artin Mahmoudi, Adventist Health Sonora; and Andrei Bobrow, Ventura County Medical Center. California Department of Public Health e-cigarette, or vaping, product use–associated lung injury investigation team includes Sonia Angell, Alanna Barres, Chante Buntin, Armando Chévez, Caroline W. Collins, Carolina Espineli, Susan Fanelli, Thomas Garrett, Kathleen Harriman, Sheena Harris, Catherine Hess, Miren Klein, Daniel Ung Kwon, Asif Maan, Mónica Morales, Nancy Ortiz, Caroline Peck, April Roeseler, Svetlana Smorodinsky, Mark Starr, Kayla Thomas, Alon Volner, Rebecca Williams, Janet Young, and the California Department of Public Health Medical and Health Coordination Center. No compensation was provided to the individuals acknowledged here.