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Frailty is increasingly recognized as a geriatric syndrome, distinct from disability and comorbidity, but relatively little is known about its natural history. In this prospective study, which included assessments of frailty at 18-month intervals among 754 community-living older persons, Gill et al found that frailty is a dynamic process, characterized by frequent transitions between frailty states over time. Transitions to states of greater frailty were more common than transitions to states of lesser frailty, and the probability of transitioning from being frail to nonfrail was very low, even over an extended period. These results suggest ample opportunity for the prevention and remediation of frailty.
In This Issue of Archives of Internal Medicine. Arch Intern Med. 2006;166(4):387. doi:https://doi.org/10.1001/archinte.166.4.387
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