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In 478 persons with peripheral arterial disease (PAD) and 292 without PAD, this study determined whether lower extremity ischemia was associated with impaired lower extremity nerve function. Among nondiabetic participants, those with severe PAD had poorer peroneal nerve conduction velocity (NCV) compared with participants without PAD, participants with mild PAD, and participants with moderate PAD. Among 224 diabetic participants, PAD was associated with poorer peroneal NCV, sural nerve amplitude, and ulnar NCV compared with the absence of PAD. Results suggest that leg ischemia impairs peroneal nerve function. This association is less strong in patients with diabetes, perhaps because of the overriding influence of diabetes on peripheral nerve function.
In This Issue of Archives of Internal Medicine. Arch Intern Med. 2006;166(18):1937. doi:10.1001/archinte.166.18.1937
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