Validation and Comparison of a Novel Screening Guideline for Kidney Disease: KEEPing SCORED | Guidelines | JAMA Internal Medicine | JAMA Network
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Research Letter
February 25, 2008

Validation and Comparison of a Novel Screening Guideline for Kidney Disease: KEEPing SCORED

Arch Intern Med. 2008;168(4):432-435. doi:10.1001/archinternmed.2007.122

Chronic kidney disease (CKD) is one of the world's major public health problems. Nearly 1 in 9 adults (20 million people) in the United States have CKD, and it is estimated that another 20 million are at increased risk.1 Given the asymptomatic nature of kidney disease, affected individuals and health care providers may be unaware of the condition in patients. Identifying individuals with early kidney disease would be a useful first step in preventing progression to end-stage renal disease as well as reducing morbidity and mortality from cardiovascular disease (CVD).

We recently published an instrument (SCreening for Occult REnal Disease [SCORED]) to systematically identify individuals with a high likelihood of prevalent CKD.2 Derived from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 and (partially) validated in the Atherosclerosis Risk in Communities (ARIC) study, SCORED identified 9 demographic and medical variables that could be assigned integer values and then entered into a scoring algorithm. The scoring algorithm was intentionally simplified to be accessible to lay persons and health care providers.

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