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In This Issue of Archives of Internal Medicine
November 28, 2005

In This Issue of Archives of Internal Medicine

Arch Intern Med. 2005;165(21):2449. doi:10.1001/archinte.165.21.2449

This article describes the experience of the Framingham Heart Study in the prediction of cardiovascular disease with C-reactive protein measurements and 8 years of follow-up. The study included 4446 adults free of cardiovascular disease at baseline; 283 developed major cardiovascular disease events. Categories of C-reactive protein were predictive of developing an event in age- and sex-adjusted models, but the effects were attenuated greatly in multivariable models.

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In this article, Gehi and colleagues examined the association between current major depression and self-reported medication adherence in 940 outpatients with coronary heart disease. Among the 204 participants with major depression, 14% reported not taking their medications as prescribed compared with 5% of nondepressed participants (odds ratio, 2.8; 95% confidence interval, 1.7-4.7; P<.001), and this relation persisted after adjustment for potential confounding variables. Greater depressive symptom severity was associated with greater nonadherence. These results raise the possibility that medication nonadherence may contribute to adverse cardiovascular outcomes in depressed patients.