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Table 1. 
Baseline Characteristics of the 21 376 US Male Physicians According to Breakfast Cereal Consumptiona
Baseline Characteristics of the 21 376 US Male Physicians According to Breakfast Cereal Consumptiona
Table 2. 
Incidence Rates and Hazard Ratios of Heart Failure by Breakfast Cereal Intake
Incidence Rates and Hazard Ratios of Heart Failure by Breakfast Cereal Intake
Table 3. 
Hazard Ratio of Heart Failure by Type and Quantity of Breakfast Cereal Consumeda
Hazard Ratio of Heart Failure by Type and Quantity of Breakfast Cereal Consumeda
1.
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Lloyd-Jones  DM The risk of congestive heart failure: sobering lessons from the Framingham Heart Study.  Curr Cardiol Rep 2001;3 (3) 184- 190PubMedGoogle ScholarCrossref
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Wilhelmsen  LRosengren  AEriksson  HLappas  G Heart failure in the general population of men–morbidity, risk factors and prognosis.  J Intern Med 2001;249 (3) 253- 261PubMedGoogle ScholarCrossref
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Truswell  AS Cereal grains and coronary heart disease.  Eur J Clin Nutr 2002;56 (1) 1- 14PubMedGoogle ScholarCrossref
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Pins  JJGeleva  DKeenan  JMFrazel  CO'Connor  PJCherney  LM Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?  J Fam Pract 2002;51 (4) 353- 359PubMedGoogle Scholar
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Liu  SSesso  HDManson  JEWillett  WCBuring  JE Is intake of breakfast cereals related to total and cause-specific mortality in men?  Am J Clin Nutr 2003;77 (3) 594- 599PubMedGoogle Scholar
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Pereira  MAO'Reilly  EAugustsson  K  et al.  Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies.  Arch Intern Med 2004;164 (4) 370- 376PubMedGoogle ScholarCrossref
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Anderson  JW Dietary fiber prevents carbohydrate-induced hypertriglyceridemia.  Curr Atheroscler Rep 2000;2 (6) 536- 541PubMedGoogle ScholarCrossref
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Burke  VHodgson  JMBeilin  LJGiangiulioi  NRogers  PPuddey  IB Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives.  Hypertension 2001;38 (4) 821- 826PubMedGoogle ScholarCrossref
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Braaten  JTWood  PJScott  FWRiedel  KDPoste  LMCollins  MW Oat gum lowers glucose and insulin after an oral glucose load.  Am J Clin Nutr 1991;53 (6) 1425- 1430PubMedGoogle Scholar
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Steering Committee of the Physicians' Health Study Research Group, Final report on the aspirin component of the ongoing Physicians' Health Study.  N Engl J Med 1989;321 (3) 129- 135PubMedGoogle ScholarCrossref
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Jacobs  DR  JrMeyer  KAKushi  LHFolsom  AR Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study.  Am J Clin Nutr 1998;68 (2) 248- 257PubMedGoogle Scholar
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Ho  KKAnderson  KMKannel  WBGrossman  WLevy  D Survival after the onset of congestive heart failure in Framingham Heart Study subjects.  Circulation 1993;88 (1) 107- 115PubMedGoogle ScholarCrossref
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Djoussé  LGaziano  JM Alcohol consumption and risk of heart failure in the Physicians' Health Study I.  Circulation 2007;115 (1) 34- 39PubMedGoogle ScholarCrossref
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D'Agostino  RBLee  MLBelanger  AJCupples  LAAnderson  KMKannel  WB Relation of pooled logistic regression to time dependent Cox regression analysis: the Framingham Heart Study.  Stat Med 1990;9 (12) 1501- 1515PubMedGoogle ScholarCrossref
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US Department of Health and Human Services, Healthy People 2010: Understanding and Improving Health.  Washington, DC US Department of Health and Human Services2000;
21.
Meyer  KAKushi  LHJacobs  DR  JrSlavin  JSellers  TAFolsom  AR Carbohydrates, dietary fiber, and incident type 2 diabetes in older women.  Am J Clin Nutr 2000;71 (4) 921- 930PubMedGoogle Scholar
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Liu  SManson  JEStampfer  MJ  et al.  A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women.  Am J Public Health 2000;90 (9) 1409- 1415PubMedGoogle ScholarCrossref
23.
Liu  SManson  JE Dietary carbohydrates, physical inactivity, obesity, and the ‘metabolic syndrome’ as predictors of coronary heart disease.  Curr Opin Lipidol 2001;12 (4) 395- 404PubMedGoogle ScholarCrossref
24.
Appel  LJMoore  TJObarzanek  E  et al.  A clinical trial of the effects of dietary patterns on blood pressure.  N Engl J Med 1997;336 (16) 1117- 1124PubMedGoogle ScholarCrossref
25.
Keenan  JMPins  JJFrazel  CMoran  ATurnquist  L Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial.  J Fam Pract 2002;51 (4) 369PubMedGoogle Scholar
26.
Svetkey  LPSimons-Morton  DVollmer  WM  et al.  Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial.  Arch Intern Med 1999;159 (3) 285- 293PubMedGoogle ScholarCrossref
27.
Dodson  PMStephenson  JDodson  LJ  et al.  Randomised blind controlled trial of a high fibre, low fat and low sodium dietary regimen in mild essential hypertension.  J Hum Hypertens 1989;3 (3) 197- 202PubMedGoogle Scholar
28.
Steffen  LMKroenke  CHYu  X  et al.  Associations of plant food, dairy product, and meat intakes with 15-y incidence of elevated blood pressure in young black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.  Am J Clin Nutr 2005;82 (6) 1169- 1177PubMedGoogle Scholar
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Bazzano  LASong  YBubes  VGood  CKManson  JELiu  S Dietary intake of whole and refined grain breakfast cereals and weight gain in men.  Obes Res 2005;13 (11) 1952- 1960PubMedGoogle ScholarCrossref
30.
Liu  SWillett  WCManson  JEHu  FBRosner  BColditz  G Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women.  Am J Clin Nutr 2003;78 (5) 920- 927PubMedGoogle Scholar
31.
Mozaffarian  DKumanyika  SKLemaitre  RNOlson  JLBurke  GLSiscovick  DS Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals.  JAMA 2003;289 (13) 1659- 1666PubMedGoogle ScholarCrossref
32.
Ness  ARHughes  JElwood  PCWhitley  ESmith  GDBurr  ML The long-term effect of dietary advice in men with coronary disease: follow-up of the Diet and Reinfarction trial (DART).  Eur J Clin Nutr 2002;56 (6) 512- 518PubMedGoogle ScholarCrossref
33.
Brancati  FLAppel  LJSeidler  AJWhelton  PK Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet: a randomized, double-blind, placebo-controlled trial.  Arch Intern Med 1996;156 (1) 61- 67PubMedGoogle ScholarCrossref
34.
Gu  DHe  JWu  XDuan  XWhelton  PK Effect of potassium supplementation on blood pressure in Chinese: a randomized, placebo-controlled trial.  J Hypertens 2001;19 (7) 1325- 1331PubMedGoogle ScholarCrossref
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Sanders  TADean  TSGrainger  DMiller  GJWiseman  H Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor beta(1) concentrations and hemostatic risk factors for coronary heart disease in healthy subjects.  Am J Clin Nutr 2002;76 (2) 373- 377PubMedGoogle Scholar
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Original Investigation
October 22, 2007

Breakfast Cereals and Risk of Heart Failure in the Physicians' Health Study I

Author Affiliations

Author Affiliations: Divisions of Aging (Drs Djoussé and Gaziano) and Preventive Medicine (Dr Gaziano), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Arch Intern Med. 2007;167(19):2080-2085. doi:10.1001/archinte.167.19.2080
Abstract

Background  Heart failure (HF) is the leading cause of hospitalization among the elderly population in the United States. Consumption of grain products and dietary fiber has been shown to reduce the risk of hypertension and myocardial infarction. However, it is not known whether a higher consumption of breakfast cereals is associated with risk of HF.

Methods  This study evaluated prospectively the association between breakfast cereal intake and incident HF among 21 376 participants of the Physicians' Health Study I. Cereal consumption was estimated using a semiquantitative food frequency questionnaire. Incident HF was ascertained through annual follow-up questionnaires and validated using Framingham criteria. We used Cox regression models to estimate adjusted relative risk of HF across categories of cereal intake.

Results  During an average follow-up of 19.6 years, 1018 incident cases of HF occurred. For average weekly cereal consumption of 0 servings, 1 or fewer, 2 to 6, and 7 or more, hazard ratios (95% confidence intervals) for HF were 1 (reference), 0.92 (0.78-1.09), 0.79 (0.67-0.93), and 0.71 (0.60-0.85), respectively (P<.001 for trend), adjusting for age, smoking, alcohol consumption, vegetable consumption, use of multivitamins, exercise, and history of atrial fibrillation, valvular heart disease, and left ventricular hypertrophy. However, the association was limited to the intake of whole grain cereals (P <.001 for trend) but not refined cereals (P = .70 for trend).

Conclusions  Our data demonstrate that a higher intake of whole grain breakfast cereals is associated with a lower risk of HF. Additional studies are warranted to confirm these findings and determine specific nutrients that are responsible for such a protection.

The lifetime risk of heart failure (HF) is estimated at 20% (1 in 5) for both men and women aged 40 years.1 While advanced age, hypertension, diabetes mellitus, obesity, valvular heart disease, and myocardial infarction have been recognized as predictors of HF,2,3 limited data are available on the effects of modifiable lifestyle factors on the risk of HF. Studies have suggested that a higher consumption of grain products may confer a lower risk of hypertension, coronary heart disease, hypercholesterolemia, and mortality.4-9 Breakfast cereals and cereal products play an important role in the US diet. Cereals contain important nutrients such as vitamins, minerals, fiber, and oil that have been reported to lower cardiovascular risk factors10-12 and positively influence glucose and insulin metabolism.13,14 In addition, cereals contain phytoestrogens and phenolic acids, which have been shown to have health benefits. It is not known whether a higher consumption of breakfast cereals is associated with a lower risk of HF. Our primary objective was to prospectively examine whether a higher consumption of total breakfast cereals was associated with a lower risk of HF among US male physicians. In addition, since some of the nutrients are lost or added (fortification) in refined cereals, we sought to examine whether a higher intake of whole grain as well as refined breakfast cereals was associated with a lower incidence of HF in this population.

Methods
Study population

This study used data from a previously reported randomized trial among US male physicians, the Physicians' Health Study I (PHS I).15 Briefly, in 1981, 261 248 US male physicians were invited to participate in the trial. After exclusions, 33 223 participants were enrolled in an 18-week run-in period. Following the run-in period, 22 071 subjects were randomized to regimens of low-dose aspirin, beta carotene, both agents, or placebo. For the current project, we excluded 695 participants because of (1) missing information on baseline breakfast cereals (n = 25), (2) prevalent HF (n = 18), and/or (3) missing covariates (n = 652). A total of 21 376 individuals with complete data were included in the present analyses. Each participant gave written informed consent, and the study protocol was approved by the institutional review board at Brigham and Women's Hospital.

Breakfast cereal consumption

Information about consumption of cold breakfast cereals was self-reported using a simple semiquantitative food-frequency questionnaire. A detailed description of the assessment of breakfast cereal intake in the PHS I has been published.8 Briefly, participants were asked to report their average number of servings of cold breakfast cereals consumed (1 serving = 1 cup [250 mL]) during the past year. Possible response categories included rarely or never consumed cereal, 1 to 3 servings per month, 1 per week, 2 to 4 per week, 5 to 6 per week, 1 per day, and 2 or more per day. In addition, the brand of cereals consumed was queried at baseline. We used an algorithm developed by Jacobs and colleagues16 to classify breakfast cereals into whole grain and refined grain. Specifically, breakfast cereals that contain at least 25% whole grain or bran by weight were classified as whole grain. This information was obtained at baseline, 18 weeks, and 24, 48, 72, 96, and 120 months after randomization.

Ascertainment of incident hf

A questionnaire was mailed to each participant every 6 months during the first year and has been mailed annually thereafter to obtain information on compliance with the intervention and the occurrence of new medical diagnoses including HF. In a pilot study, we found a higher confirmation rate (90%) of HF using the Framingham criteria.17 A detailed description of HF validation has been published elsewhere.18

Other variables

Information on age, height, weight, body mass index, cigarette smoking, vegetable consumption, hypertension, use of multivitamins, atrial fibrillation, valvular disease, diabetes mellitus, and physical activity was collected at baseline. Incidence of major chronic disease was ascertained through annual follow-up questionnaires.

Statistical analysis

We used total breakfast cereals as the main exposure. However, we conducted stratified analyses by whole grain vs refined breakfast cereals. Because there was a good correlation between reported breakfast cereals at baseline and at 18 weeks (weighted κ = 0.71), we substituted missing values at baseline using reported cereals at 18 weeks in 756 individuals. Excluding these individuals with missing baseline cereal data did not alter the results (P < .001 for trend in fully adjusted model; data not shown). Since the distribution of total, refined, and whole grain cereals was skewed to the right, we did not use quantiles to categorize cereal consumption. We grouped adjacent categories to allow sufficient number of person-times per category and to maintain a gradient of exposure as previously described.8 Thus, we classified each subject into 1 of the following categories of average number of cereal servings consumed per week: 0, 1 or fewer, 2 to 6, and 7 or more. We calculated person-time of follow-up from baseline until the first occurrence of (1) HF, (2) death, or (3) censoring date—date of receipt of last follow-up questionnaire.

Within each breakfast cereal group, we calculated the incidence rate of HF by dividing the number of HF cases by the corresponding person-time. We used Cox proportional hazard models to compute multivariable adjusted hazard ratios with corresponding 95% confidence intervals (CIs) using subjects in the cereal category of 0 servings per week as the reference group. We assessed confounding by using 10% change in hazard ratio. Assumptions for the proportional hazard models were tested (by including main effects and product terms of covariates and a logarithmic transformed time factor) and were met (P>.05 for all). We obtained P value for linear trend by treating the cereal variable as ordinal (taking values of 0, 1, 2, and 3 from the lowest to the highest category of cereal intake).

The initial model controlled for age. The fully adjusted model included age, smoking status (never, past, or current smokers), alcohol consumption (<1, 1-4, 5-6, or ≥7 drinks per week), vegetable consumption (<3, 3-4, 5-6, 7-13, or ≥14 servings per week), use of multivitamin (never, past, or current), physical activity (<1 or ≥1 time per week), and history of atrial fibrillation, left ventricular hypertrophy, and valvular heart disease. To examine whether the effect of breakfast cereals on HF was mediated by body mass index, diabetes mellitus, coronary heart disease, and hypertension, we included these variables in the full model to see if their inclusion led to an attenuation of the hazard ratios.

In secondary analyses, we excluded individuals with a follow-up time of 2 years of less. Finally, we repeated the main analysis using updated cereal consumption data at 24, 48, 72, 96, and 120 months. For the last analysis, we used pooled logistic regression. Results from pooled logistic regression have been shown to be equivalent to those obtained from Cox regression model.19 All analyses were completed using SAS, version 9.1 (SAS Institute, Cary, North Carolina). Significance level was set at P = .05.

Results

Among 21 376 participants in the PHS I, the mean ± SD age at randomization was 53.7 ± 9.5 years (age range, 40-86 years). Table 1 summarizes the baseline characteristics of the study participants. Frequent consumption of breakfast cereals was associated with (1) older age; (2) higher consumption of vegetables; (3) a higher proportion of current drinkers, those engaging in physical activity at least once a week, and users of multivitamins; (4) a lower proportion of current smokers; and (5) a lower prevalence of hypertension.

During an average follow-up of 19.6 years, 1018 new cases of HF occurred. The crude incidence rates of HF were 26.7, 24.1, 22.2, and 23.3 cases per 10 000 person-years for cereal consumption of 0, 1 or fewer, 2 to 6, and 7 or more servings per week, respectively. In the multivariable Cox regression model, corresponding hazard ratios (95% CIs) for HF were 1 (reference), 0.92 (0.78-1.09), 0.79 (0.67-0.93), and 0.71 (0.60-0.85), respectively, after adjustment for age, smoking (never, past, or current smokers), alcohol consumption (<1, 1-4, 5-6, or ≥7 drinks per week), vegetable consumption (<3, 3-4, 5-6, 7-13, or ≥14 servings per week), use of multivitamin (never, past, or current), physical activity (<1 or ≥1 time per week), and history of atrial fibrillation, left ventricular hypertrophy, and valvular heart disease (P< .001 for linear trend) (Table 2). The use of updated cereal consumption data at 24, 48, 72, 96, and 120 months yielded a similar inverse association between cereal consumption and risk of HF (P = .03 for trend). Additional adjustment for potential intermediate factors such as body mass index, hypertension, myocardial infarction, and diabetes mellitus resulted in a modest attenuation of the effect measure with corresponding relative risks (95% CIs) of 1 (reference), 0.91 (0.77-1.08), 0.83 (0.71-0.99), and 0.80 (0.67-0.96), respectively (P = .01 for trend). Finally, exclusion of individuals whose follow-up times were 2 years or less had no effect on the relative risks (P < .001 for trend; data not shown).

However, when we stratified by the type of breakfast cereals consumed, we observed an inverse association between whole grain cereals and HF (P < .001 for trend) but not with refined cereals (P = .70 for trend) (Table 3). Adjustment for intermediate factors (body mass index, myocardial infarction, hypertension, and diabetes) attenuated the relative risks modestly with corresponding hazard ratios (95% CIs) of 1 (reference), 0.85 (0.68-1.06), 0.82 (0.68-1.01), and 0.81 (0.66-0.99), from the lowest to the highest category of whole grain breakfast cereals, respectively (P = .02 for trend).

Comment

In the present prospective study, we demonstrated that a higher consumption of breakfast cereals was associated with a lower risk of HF among US male physicians. However, this association was mainly present in individuals consuming whole grain breakfast cereals but not refined breakfast cereals. To our knowledge, this is the first study to prospectively examine the relation between breakfast cereal consumption and the risk of HF in a large cohort.

Dietary guidelines recommend a consumption of grain products for health benefits.20 Cereal grains and their products represent an important source of energy in the US population. Depending on the type (whole vs refined), cereals can provide substantial amounts of proteins, oils, fiber, potassium, selenium, and vitamins and other nutrients.6 Processing generally reduces the content of these nutrients and bioprotective substances. Previous epidemiologic studies have reported beneficial effects of fiber, minerals, and certain vitamins on coronary heart disease,9 weight, type 2 diabetes mellitus,21,22 and hypertension23,24 (all of which are determinants of HF). Specifically, in a randomized placebo-controlled trial,25 consumption of 5.52 g/d of oat cereals was associated with a 7.5–mm Hg reduction in systolic blood pressure (P < .01) and a 5.5–mm Hg reduction in diastolic blood pressure (P < .02) after 6 weeks of intervention among 18 men and women with hypertension and hyperinsulinemia; in contrast, no effect was observed in the placebo group of that trial. Other clinical trials using an intervention consisting of a high-fiber, low-fat, and low-sodium diet reported similar reductions in blood pressure.7,26,27 Data from the Coronary Artery Risk Development in Young Adults Study28 reported a lower incidence of elevated blood pressure with consumption of whole grain but not refined grains.

Cereal consumption has been shown to favorably influence other risk factors for HF. A previous report from this cohort demonstrated an inverse association between total breakfast cereals and whole and refined cereals and body mass index and weight gain over time.29 In addition, higher consumption of whole grains and dietary fiber was inversely associated with weight and weight gain over 12 years among 74 091 US female nurses30 and US male physicians.29 In contrast, refined grain was positively associated with weight gain over time in women30 but not in men.29

Epidemiologic data on the effects of cereals or dietary fiber on the risk of coronary heart disease remains inconsistent. In a meta-analysis of 10 prospective cohorts,9 each 10-g/d increment of energy-adjusted total dietary fiber was associated with a 14% decrease in risk of all coronary events (P = .01) and a 27% decrease in risk of coronary death (P < .001). The relative risks (95% CIs) for any coronary event and coronary death associated with a 10-g/d increment of cereal fiber were 0.90 (0.77-1.07) and 0.75 (0.63-0.91), respectively.9 Previous data from the PHS I showed an inverse association between whole grain breakfast cereals and cardiovascular disease (CVD) mortality (P = .01 for trend), whereas refined breakfast cereal consumption was associated with a statistically nonsignificant increased risk of CVD mortality.8 In addition, cereal fiber intake was inversely associated with incident CVD in the Cardiovascular Health Study.31 Contrary to most cohort studies, the Diet and Reinfarction trial (DART)32 did not show any benefit of cereal fiber consumption on the risk of coronary heart disease, stroke, or all-cause mortality. Of note is that the DART was a secondary prevention trial in men with coronary disease, thus making it more difficult to detect a small effect of cereal fiber given the elevated baseline risk of CHD in the group that did not receive advice to consume more cereal fiber. Alternatively, residual confounding and/or uncontrolled confounding could partially explain the beneficial effects of cereals/fiber observed in cohort studies.

There are several biological mechanisms by which whole grain cereals could protect against incident HF. Nutrients such as potassium contained in whole grain cereals have been shown to lower blood pressure.33,34 In addition, other constituents of cereals may exert beneficial effects on lipid and homocysteine levels or possess antioxidant properties.6,35,36 Phytoestrogens contained in whole grain cereals may improve lipid levels37,38 and insulin sensitivity.39 Slowing starch digestion or absorption and promoting satiety are possible mechanisms by which whole grain cereals may help control body weight.40 The attenuation of hazard ratios found after additional adjustment for body mass index, hypertension, myocardial infarction, and diabetes mellitus supports the hypothesis that beneficial effects of whole grain cereals on HF risk are mediated partially through these physiologic mechanisms. The fact that we still found a statistically significant P value for trend after adjusting for intermediate factors is more likely due to measurement errors in our data and/or unmeasured confounding.

Our study has some limitations. First, we did not collect data to distinguish HF with and without preserved left ventricular function. Second, we used a simple semiquantitative food frequency questionnaire to collect dietary information. Thus, we were not able to control for total energy intake and other nutrients in the diet. Third, there is a possibility of inaccurate reporting of consumption of breakfast cereals, which might have led to exposure misclassification. Fourth, the fact that our sample consists of highly educated male physicians who may have different behaviors than the general population limits the generalizability of our findings. Finally, given the intercorrelation between cereal consumption and other dietary or lifestyle factors, our data cannot precisely estimate the net contribution of cereal consumption on the observed association. Nevertheless, the large sample size, the longer duration of follow-up, and the fact that participants were physicians who could recognize early signs of HF are strengths of the present study.

In conclusion, our data showed an inverse association between consumption of whole grain breakfast cereals and incident HF. Such association is more likely to be mediated through beneficial effects of whole grains on risk factors of HF such as hypertension, myocardial infarction, diabetes mellitus, and obesity. If confirmed in other studies, a higher intake of whole grains along with other preventive measures could help lower the risk of HF.

Correspondence: Luc Djoussé, MD, MPH, DSc, Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont St, Third Floor, Boston, MA 02120 (ldjousse@rics.bwh.harvard.edu).

Accepted for Publication: June 25, 2007.

Author Contributions: Drs Djoussé and Gaziano have full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Djoussé and Gaziano. Acquisition of data: Gaziano. Analysis and interpretation of data: Djoussé and Gaziano. Drafting of the manuscript: Djoussé. Critical revision of the manuscript for important intellectual content: Djoussé and Gaziano. Statistical analysis: Djoussé. Obtained funding: Djoussé and Gaziano. Administrative, technical, and material support: Gaziano. Study supervision: Gaziano.

Financial Disclosure: Dr Gaziano has received investigator-initiated research grants from BASF, DSM Pharmaceuticals, Wyeth Pharmaceuticals, McNeil Consumer Products, and Pliva as well as honoraria from Bayer and Pfizer for speaking engagements. He is a consultant for Bayer, McNeil Consumer Products, Wyeth Pharmaceuticals, Merck, Nutraquest, and GlaxoSmithKline.

Funding/Support: The PHS is supported by grants CA-34944 and CA-40360 from the National Cancer Institute and grants HL-26490 and HL-34595 from the National Heart Lung and Blood Institute (NHLBI), Bethesda, Maryland. Dr Djoussé is supported by grant K01 HL-70444 from the NHLBI.

Role of the Sponsor: The sponsors had no role in the conduct of the study.

Additional Contributions: We thank the participants in the PHS for their outstanding commitment and cooperation and also thank the entire PHS staff.

References
1.
Lloyd-Jones  DMLarson  MGLeip  EP  et al.  Lifetime risk for developing congestive heart failure: the Framingham Heart Study.  Circulation 2002;106 (24) 3068- 3072PubMedGoogle ScholarCrossref
2.
Lloyd-Jones  DM The risk of congestive heart failure: sobering lessons from the Framingham Heart Study.  Curr Cardiol Rep 2001;3 (3) 184- 190PubMedGoogle ScholarCrossref
3.
Wilhelmsen  LRosengren  AEriksson  HLappas  G Heart failure in the general population of men–morbidity, risk factors and prognosis.  J Intern Med 2001;249 (3) 253- 261PubMedGoogle ScholarCrossref
4.
Khaw  KTBarrett-Connor  E Dietary fiber and reduced ischemic heart disease mortality rates in men and women: a 12-year prospective study.  Am J Epidemiol 1987;126 (6) 1093- 1102PubMedGoogle Scholar
5.
Pietinen  PRimm  EBKorhonen  P  et al.  Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men: the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.  Circulation 1996;94 (11) 2720- 2727PubMedGoogle ScholarCrossref
6.
Truswell  AS Cereal grains and coronary heart disease.  Eur J Clin Nutr 2002;56 (1) 1- 14PubMedGoogle ScholarCrossref
7.
Pins  JJGeleva  DKeenan  JMFrazel  CO'Connor  PJCherney  LM Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?  J Fam Pract 2002;51 (4) 353- 359PubMedGoogle Scholar
8.
Liu  SSesso  HDManson  JEWillett  WCBuring  JE Is intake of breakfast cereals related to total and cause-specific mortality in men?  Am J Clin Nutr 2003;77 (3) 594- 599PubMedGoogle Scholar
9.
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