[Skip to Content]
[Skip to Content Landing]
Article
March 1922

STUDY OF BLOOD SUGAR CURVES FOLLOWING A STANDARDIZED GLUCOSE MEAL

Author Affiliations

ST. LOUIS

From the Metabolic Unit of the Department of Medicine, Washington University School of Medicine.

Arch Intern Med (Chic). 1922;29(3):384-399. doi:10.1001/archinte.1922.00110030109007
Abstract

The following study is concerned with the effort to demonstrate the main factors which influence the duration of hyperglycemia after a glucose meal. More than 200 cases have been studied critically. There is extensive literature on the subject of blood sugar curves after various sorts of carbohydrate meals. In some studies standardized meals were given, in others not. Many clinicians have assigned diagnostic importance to an increased hyperglycemia following glucose ingestion.

The interpretation of the value of sugar curves depends on the following factors: (1) The technic of the administration of the glucose meal; (2) the collection of blood samples; (3) the method of doing the blood sugar determination, and (4) the wide application of the test so as to learn the many factors which influence these curves.

We believe it necessary, in order to support our conclusions, to discuss the first three of these points in detail.

Standardized Glucose 

References
1.
Janney:  Proc. Soc. Exper. Biol. & Med. 15: 1917-1918.
2.
Janney and Isaacson:  J. A. M. A. 70:1131 ( (April 20) ) 1918.Crossref
3.
Fisher & Wishart:  J. Biol. Chem. 13:49, 1912.
4.
Janney:  J. Biol. Chem. 22:191, 1915.
5.
Sansum and Woodyatt:  J. Biol. Chem. 30:155, 1917.
6.
Palmer:  J. Biol. Chem. 30:79, 1917.
7.
Allen, Wishart and Smith:  Arch. Int. Med. 24:523 ( (Oct.) ) 1919.Crossref
8.
Boothby:  J. A. M. A. 77:252 ( (July 23) ) 1921.Crossref
9.
Meyers and Bailey:  J. Biol. Chem. 24:147, 1916.
10.
Cowie and Parsons:  Arch. Int. Med. 26:333 ( (Sept.) ) 1920.Crossref
11.
Shaffer and Hartmann:  J. Biol. Chem. 45:365, 1921.
12.
Hammon and Hirschman:  Arch. Int. Med. 20:761 ( (Dec.) ) 1917.Crossref
13.
Janney and Isaacson:  Arch. Int. Med. 22:160 ( (Aug.) ) 1918.Crossref
14.
Janney and Henderson,  Arch. Int. Med. 26:297 ( (Sept.) ) 1920.Crossref
15.
Pemberton and Foster:  Arch. Int. Med. 25:243 ( (Feb.) ) 1920.Crossref
16.
Lusk: Science of Nutrition, p. 522
17.
Langfeldt:  J. Biol. Chem. 46:381, 1921.
18.
Cushing:  The Pituitary Body and Its Disorders , Lippincott, 1911.
19.
Weed, Cushing and Jacobson:  Bull. Johns Hopkins Hosp. 24:40, 1913.
20.
Cannon:  Bodily Changes in Pain, Hunger, Fear and Rage , New York, D. Appleton, 1920.
21.
For permission to study these cases we are indebted to Prof. Sidney I. Schwab.
22.
Underhill and Hilditch:  Am. J. Physiol. 25:66, 1909.
23.
Underhill and Blatherwick:  Am. J. Chem. 18:87, 1914.
24.
Cramer and Krause:  Quart. J. Exper. Physiol. 11:59, 1917.
25.
Cramer and McCall:  Quart. J. Exper. Physiol. 12:81, 1918.
×