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Article
January 1940

PURPURA HAEMORRHAGICA DUE TO INGESTION OF SEDORMID (ALLYLISOPROPYLACETYLCARBAMIDE): EXPERIMENTAL OBSERVATIONS AND REPORT OF A CASE

Author Affiliations

SAN FRANCISCO

From the Department of Medicine, University of California Medical School.

Arch Intern Med (Chic). 1940;65(1):122-137. doi:10.1001/archinte.1940.00190070132009
Abstract

In 1933, Dennig1 reported 3 cases of purpura haemorrhagica due to oral administration of iodifix, a preparation containing iodine. One of the patients, a woman aged 64, after recovery from iodine purpura had two distinct relapses, each following the use of 1 tablet of sedormid (allylisopropylacetylcarbamide), a drug that she had not used previously. From 1933 to October 1938 reports of instances of purpura haemorrhagica following the use of sedormid2 appeared in rapidly increasing numbers, as evidenced by our having found, in the literature covering this period of approximately five years, reports of 41 cases. Including our reported case, the total number of cases at the time of writing (November 1938) is 42. We have prepared a table (table 1) setting forth the names of the authors and their reports of cases during the period mentioned. Pertinent data in connection with these published cases have been tabulated for

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