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Article
January 1942

SERUM PROTEINS IN CIRRHOSIS OF THE LIVER: I. RELATION TO PROGNOSIS AND TO FORMATION OF ASCITES

Author Affiliations

NEW YORK

From the Research Service, 1st Medical (Columbia) Division, Welfare Hospital, and the Department of Medicine, Columbia University College of Physicians and Surgeons.

Arch Intern Med (Chic). 1942;69(1):67-82. doi:10.1001/archinte.1942.00200130077007
Abstract

Filinski1 reported that in diseases of the liver, such as cirrhosis, catarrhal jaundice, amyloidosis and carcinomatosis from primary carcinoma of the bile duct, the albumin-globulin ratio of the serum was reversed. He concluded that the alterations in serum protein values were due to pathologic changes in the liver. In many subsequent reports containing single observations on the serum proteins of patients with cirrhosis of the liver, authors2 agreed that the albumin-globulin ratio may be reversed in the presence of this disease. However, it has not been clear what relation the changes in serum protein bear to the course of the disease and to the formation of ascites.

Snell2e has stated that "the ratio tends to return to normal as improvement takes place," although he has not published data pertinent to this observation. Foley, Keeton, Kendrick and Darling2h reported data on 1 patient with cirrhosis of the liver and ascites

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The serum proteins were determined by the Howe method of precipitating the globulin fraction, together with the mico-Kjeldahl distillation technic.
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Footnote 2 a-k.
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