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August 1957

Acetyldigitoxin in Clinical Practice

Author Affiliations
Butte, Mont.
AMA Arch Intern Med. 1957;100(2):209-213. doi:10.1001/archinte.1957.00260080035008

Since the introduction of digitalis into the practice of medicine by William Withering, in 1785, as a diuretic,1 numerous preparations have been tried in the search for an ideal drug for cardiac disease, one that is not only effective but also less toxic. Goodman and Gilman2 stated that a "nontoxic digitalis does not exist. A digitalis preparation which will not cause poisoning when given in excess is also one which will not exert any therapeutic effect."

Reports of the use of acetyldigitoxin have appeared in the European literature,3-6 and they have stated that it is an effective, rapidacting, well-absorbed, fairly rapidly excreted, well-tolerated digitalis preparation, but there have been relatively few American clinical trials.7 -16

Acetyldigitoxin (Acylanid) is a purified glycoside prepared first by Stoll and Kreis 17 by the enzymatic cleavage of a glucose molecule from lanatoside A, the glycoside

derived from Digitalis lanata.

Major, R. H.:  Classic Description of Diseases with Biographical Sketches of the Authors , Ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1939, p. 479.
Goodman, L., and Gilman, A.:  The Pharmacological Basis of Therapeutics; A Textbook of Pharmacology, Toxicology, and Therapeutics for Physicians and Medical Students , Ed. 2, New York, The Macmillan Company, 1955, p. 686.
Hoburg, H.:  Beitrag zur differenzierten Therapie der Herzinsuffizienz ,  München. med. Wchnschr. 98:199 ( (Jan.) ) 1956.
Trolliet, J.; Conne, G., and Dreyfuss, R.:  Résultats thérapeutiques obtenus avec l'Acétyl-Digitoxine Sandoz ,  Praxis 42:310 ( (April 16) ) 1953.
Häusler, H. P., and Hörtnagl, W.:  Klinisch-experimentelle Untersuchungen über die Herz- und Kreislaufwirksamkeit eines neuen Digitalis-Rein- glykosides (Acetyl-Digitoxin) ,  Wien. klin. Wchnschr. 65:473 ( (May 29) ) 1953.
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Löffler, W.; Essellier, A. F., and Forster, G.:  Acetyl-Digitoxin: Clinical Observations on the Treatment of Patients with Advanced Congestive Heart Failure ,  Am. Heart J. 47:898 ( (June) ) 1954.Crossref
Maher, C. C., Jr., and Pullen, C. W.:  Acetyldigitoxin: A New Cardiac Glycoside ,  Rocky Mountain M. J. 52:436 ( (May) ) 1955.
Zilli, A., and Luisada, A. A.:  Effects of Acetyl-Digitoxin a in Ambulatory Patients with Congestive Failure ,  Exper. Med. & Surg. 13:118, 1955.
Crouch, R. B.; Hejtmancik, M. R., and Herrmann, G. R.:  A Clinical Evaluation of Acetyl-Digitoxin ,  Am. Heart J. 51:609 ( (April) ) 1956.
Goldfarb, M.; Thorner, M. C., and Griffith, G. C.:  Clinical Experience with Acetyl-Digitoxin: Preliminary Report ,  Am. J. M. Sc. 231:186 ( (Feb.) ) 1956.
Brill, I. C.; Burgner, P. R., and David, N. A.:  Acetyl-Digitoxin (Acylanid): Rapid Digitalization and Maintenance by Oral Administration ,  Ann. Int. Med. 44:707 ( (April) ) 1956.
Gillis, H. B.:  Acetyl Digitoxin: A New Cardiac Glycoside ,  Northwest Med. 55:418 ( (April) ) 1956.
Gunther, L.; Baum, R. N.; Elek, S. R.; John, D., and Levy, I.:  A Clinical Evaluation of Acetyl-Digitoxin ,  Am. Heart J. 52:290 ( (Aug.) ) 1956.
Shah, S. J.; Rubler, S., and Weston, R. E.:  Clinical Studies on a New Cardiac Glycoside, Acetyldigitoxin ,  J. A. M. A. 161:1543 ( (Aug. 18) ) 1956.
Bernstein, A.; Kogan, E., and Cohen, I. E.:  Acetyl-Digitoxin: A Clinical Study ,  Journal-Lancet 76:228 ( (Aug.) ) 1956.
Stoll, A., and Kreis, W.:  Acetyldigitoxin-Alpha und Acetyldigitoxin-Beta ,  Helvet. chim. acta 35:1318, 1952.
Stoll, A.:  The Cardiac Glycosides , London, The Pharmaceutical Press, 1937.
Kay, C. F.:  The Clinical Use of Digitalis Preparations ,  Circulation 12:291 ( (Aug.) ) 1955.