[Skip to Content]
[Skip to Content Landing]
Article
January 1960

The Prognostic Significance of So-Called Mallory Bodies in Portal Cirrhosis

Author Affiliations

West Haven, Conn.

From the Laboratory Service, Veterans Administration Hospital.

AMA Arch Intern Med. 1960;105(1):99-104. doi:10.1001/archinte.1960.00270130115014
Abstract

In 1911, F. B. Mallory1 called attention to a peculiar hyaline change in the liver cells in alcoholic cirrhosis. It consisted of the appearance of a coarse, eosinophilic meshwork in the cytoplasm of single hepatic cells or groups of cells, followed by necrosis and invasion by polymorphonuclear leukocytes and mononuclear phagocytes, then by connective tissue proliferation at the site of necrosis. This hyaline change in the liver cells was thought to be so characteristic of the pathogenesis of the cirrhotic process that it was termed "alcoholic hyaline." Subsequently these cytoplasmic changes have been termed "Mallory bodies."

While it has been well established that Mallory bodies are neither limited to the cirrhotic livers of alcoholics nor are peculiar to portal cirrhosis,2,3 they are most frequently seen in portal cirrhosis and most often in the active phase of the disease where inflammatory changes predominate. Thus the presence of Mallory bodies,

References
1.
Mallory, F. B.:  Cirrhosis of the Liver: Five Different Types of Lesions from Which It May Arise ,  Bull. Johns Hopkins Hosp. 22:69, 1911.
2.
Moon, V. H.:  Histogenesis of Atrophic Cirrhosis ,  Arch. Path. 13:691, 1932.
3.
Baggenstoss, A. H., and Stauffer, M. H.:  Posthepatitic and Alcoholic Cirrhosis: Clinicopathologic Study of 43 Cases of Each ,  Gastroenterology 22:157, 1952.
4.
Rather, L. J.:  Hepatic Cirrhosis and Testicular Atrophy ,  Arch. Int. Med. 80:397, 1947.Crossref
5.
Mallory, T. B., in  Case Records of the Massachusetts General Hospital ,  New England J. Med. 237:339, 1947.Crossref
6.
Davidson, C. S.:  Cirrhosis of the Liver ,  Am. J. Med. 16:863, 1954.Crossref
7.
Phillips, G. B., and Davidson, C. S.:  Acute Hepatic Insufficiency of the Chronic Alcoholic ,  A.M.A. Arch. Int. Med. 94:585, 1954.Crossref
8.
Lacquer, G. L.:  A Selective Stain for Cytoplasmic Hyaline Bodies in Laennec's Cirrhosis ,  Am. J. Clin. Path. 20:689, 1950.
9.
Roque, A. L.:  Chromotrope Aniline Blue Method of Staining Mallory Bodies of Laennec's Cirrhosis ,  Lab. Invest. 2. :15, 1953.
10.
Klatskin, G., and Yesner, R.:  Factors in the Treatment of Laennec's Cirrhosis: I. Clinical and Histological Changes Observed During a Control Period of Bed Rest, Alcohol Withdrawal, and a Minimal Basic Diet ,  J. Clin. Invest. 28:723, 1949.Crossref
11.
Seife, M.; Kessler, B. J., and Lisa, J. R.:  Clinical, Functional and Needle Biopsy Study of the Liver in Alcoholism ,  Arch. Int. Med. 86:658, 1950.Crossref
×