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Article
February 1960

Circulatory Changes Associated with Osteolytic and Osteoblastic Reactions in Bone: The Possible Mechanism Involved in Massive Osteolysis: An Experimental Study

Author Affiliations

New York

From the Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Me.

AMA Arch Intern Med. 1960;105(2):199-216. doi:10.1001/archinte.1960.00270140021004
Abstract

Osseous tissue, as is well known, does not remain static. It is constantly undergoing absorption and replacement. The process probably depends on a balanced activity between osteoblasts and osteoclasts, a chemical balance between Ca and P, changes in lymph or blood flow, and/or upon some other unknown cause. When there are still such gaps in our knowledge of the physiological production and absorption of bone, it is quite evident that there must be considerably more uncertainty as to the exact mechanism involved in pathologic states, when new bone is formed or old bone is resorbed. Osteolysis has been found associated with a great variety of conditions, including infections, trauma, tumors, hyperparathyroidism, gout, the reticuloses, scleroderma, leprosy, syringomyelia, and tabes (the Charcot joint).

In addition to the foregoing, however, there is a strange, very rare, type of osteolysis which is characterized by the complete disappearance of one or more bones. Occasional

References
1.
Bevelander, G.:  Histogenesis and Histochemistry of the Exoskeleton of Molluscs and Echinoderms . American Association for Advancement of Science Symposium, Section Nd (Dentistry), Washington, D.C. (Dec.) 1958.
2.
Binkley, J. S., and Stewart, F. W.:  Morphogenesis of Extraskeletal Osteogenic Sarcoma and Pseudo-Osteosarcoma ,  Arch. Path. 29:42-56, 1940.
3.
Blair, H. C.:  The Alteration of Blood Supply as a Cause for Normal Calcification of Bone ,  Surg. Gynec. & Obst. 67:413-423, 1938.
4.
Brunschwig, A., and Bissell, A. D.:  Production of Osteosarcoma in a Mouse by the Intramedullary Injection of 1,2-Benzpyrene ,  Arch. Surg. 36:53-60 ( (Jan.) ) 1938.
5.
Fawcett, D. W., in Greep, R. O.:  Histology , New York, Blakiston Company (division of Mc-Graw-Hill Book Company, Inc.), 1954, p. 953.
6.
Follis, R. H.: Cartilage and Matrix: Chemical Structure, Formation and Destruction, in Metabolic Interrelations with Special Reference to Calcium: Transactions of Fourth Conference, New York, Jan. 7-8, 1952, edited by E. C. Reifenstein Jr., and S. L. Wells, New York, Josiah Macy, Jr., Foundation, 1952.
7.
Goldhaber, P.:  The Effect of Hyperoxia on Bone Resorption in Tissue Culture ,  A.M.A. Arch. Path. 66:635-641, 1958.
8.
Gorham, L. W.; Wright, A. W.; Shultz, H. H., and Maxon, F. C., Jr.:  Disappearing Bones: A Rare Form of Massive Osteolysis; Report of Two Cases, One with Autopsy Findings ,  Am. J. Med. 17:674-682, 1954.
9.
Gorham, L. W., and Stout, A. P.:  Massive Osteolysis (Acute Spontaneous Absorption of Bone, Phantom Bone, Disappearing Bone) Its Relation to Hemangiomatosis ,  J. Bone & Joint Surg. 37-A:985-1004, 1955.
10.
Gutman, E. B.; Sproul, E. E., and Gutman, A. B.:  Significance of Increased Phosphatase Activity of Bone at the Site of Osteoplastic Metastases Secondary to Carcinoma of the Prostate Gland ,  Am. J. Cancer 28:485-495, 1936.
11.
Hancox, N. M.:  The Osteoclast ,  Biol. Rev. 24:448-471, 1949.
12.
Huggins, C. B.:  The Phosphatase Activity of Transplants of the Epithelium of the Urinary Bladder to the Abdominal Wall Producing Heterotopic Ossification ,  Biochem. J. 25:728-732, 1931.
13.
Johnson, P. M., and McClure, J. G.:  Observations on Massive Osteolysis: A Review of the Literature and a Report of a Case ,  Radiology 71: 28-41, 1958.
14.
Kay, H. D.:  The Role of Phosphatase in Normal and Diseased Bone ,  Physiol. Rev. 12:384, 1932.
15.
King, E. S. J.:  Localized Rarefying Conditions of Bone : London, Edward Arnold & Co. 1935; Baltimore, Wm. Wood Co., 1935.
16.
Leriche, R., and Policard, A.:  Normal and Pathological Physiology of Bone: Its Problems , translated by S. Moore and J. A. Key, St. Louis, The C. V. Mosby Company, 1928.
17.
Maksimov, A. A., and Bloom, W.:  A Textbook of Histology , Ed. 7, Philadelphia and London, W. B. Saunders Company, 1957, p. 136.
18.
Mendlowitz, M., and Leslie, A.:  The Experimental Simulation in the Dog of the Cyanosis and Hypertrophic Osteoarthropathy Which are Associated with Congenital Heart Disease ,  Am. Heart J. 24:141-152, 1942.
19.
Milch, R. A., and Changus, G. W.:  Response of Bone to Tumor Invasion ,  Cancer 9:340-351, 1956.
20.
Pearse, H. E., and Morton, J. J.:  The Influence of Alterations in the Circulation on the Repair of Bone ,  J. Bone & Joint Surg. 13:68-74, 1931.
21.
Servelle, M., and Trinquecoste, P.:  Des Angiomes veineux ,  Arch. mal. coeur 41:436-442, 1948.
22.
Sharpe, W. S., and McDonald, J. R.:  Reaction of Bone to Metastasis from Carcinoma of the Breast and Prostate ,  Arch. Path. 33:312-325, 1942.
23.
Stetten, DeWitt, Jr.: Personal communication to the author.
24.
Stout, A. P.:  Tumors of Blood Vessels ,  Texas J. Med. 40:362-365, 1944.
25.
Sutro, C. J., and Pomerantz, L.:  Effect of Experimentally Formed Tumors on the Musculo-Skeletal System of the Rat ,  Arch. Surg. 38:1132-1149, 1939.
26.
Svartz-Malmberg, G.:  Unilateral Clubbing of the Fingers in a Child with Obstruction of the Subclavian Artery ,  Acta paediat. 45:252-258, 1956.
27.
von Recklinghausen, F.: Die fibröse oder deformirende Ostitis, die Osteomalacie und die osteoplastiche Carcinose in ihren gegenseitigen Beziehungen, Separatabdruck aus der Rud. Virchow zum 13 Oktober 1891 gewidmeten Festschrift der Assistenten (70th Birthday), p. 31.
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