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Article
February 1960

The Role of X-Ray Therapy to the Neck Region in the Production of Thyroid Cancer in Young People: A Report of Thirty-Seven Cases

Author Affiliations

Baltimore

From the Department of Medicine, The Johns Hopkins University School of Medicine and The John Hopkins Hospital. Assistant in Medicine (Dr. Wilson); Associate Professor of Medicine (Dr. Asper).

AMA Arch Intern Med. 1960;105(2):244-251. doi:10.1001/archinte.1960.00270140066007
Abstract

Duffy and Fitzgerald,1 in 1950, first called attention to the frequent association of x-ray therapy to the thymus gland of infants to the later appearance of thyroid carcinoma. Subsequently many clinical reports have appeared, not only substantiating this association2-8 but enlarging it to include any early irradiation received about the head and neck. Although these subsequent data have not provided definitive proof that a causal relationship exists between the two, they have indicated a sufficiently high frequency of occurrence to imply guilt by association. A history of previous irradiation, however, has not been found in all children with thyroid cancer,9-13 and the possible fallacies of drawing too strong inferences of cause and effect between the one and the other have been pointed out.13 Duffy14 has recently summed up his experiences, and the present study, although not supplying unequivocal proof, is in agreement with his conclusion that the bulk of evidence

References
1.
Duffy, B. J., Jr., and Fitzgerald, P. J.:  Cancer of the Thyroid in Children: A Report of Twentyeight Cases ,  J. Clin. Endocrinol. 10:1296, 1950.Crossref
2.
Clark, D. E.:  Association of Irradiation with Cancer of the Thyroid in Children and Adolescents ,  J.A.M.A. 159:1007, 1955.Crossref
3.
Majarakis, J. D.; Slaughter, D. P., and Cole, W. H.:  Thyroid Cancer in Childhood and Adolescence ,  J. Clin. Endocrinol. 16:1487, 1956.Crossref
4.
Fetterman, G. H.:  Carcinoma of the Thyroid in Children ,  A.M.A.J. Dis. Child. 92:581, 1956.Crossref
5.
Charache, H.:  Mixed Tumor of the Submaxillary Gland, Treated by Surgery and Radiation, Followed Eighteen Years Later by Carcinoma of the Thyroid ,  J. Pediat. 49:733, 1956.Crossref
6.
Bérard, F.; André, P., and Pinel, J.:  Third Observation of Cancer of Body of Thyroid After Radiotherapy for Laryngeal Papilloma ,  Ann. oto.laryng. 74:829, 1957.
7.
Skandalakis, J. E.; Rand, E. O., and Poer, D. H.:  Malignant Tumors of the Thyroid Gland ,  J.M.A. Georgia 47:165, 1958.
8.
Rooney, D. R., and Powell, R. W.:  Carcinoma of the Thyroid in Children After X-Ray Therapy in Early Childhood ,  J.A.M.A. 169:1, 1959.Crossref
9.
Warren, S.; Alvizouri, M., and Colcock, B. P.:  Carcinoma of the Thyroid in Childhood and Adolescence ,  Cancer 6:1139, 1953.Crossref
10.
Horn, R. C., Jr., and Ravdin, I. S.:  Carcinoma of the Thyroid Gland in Youth ,  J. Clin. Endocrinol. 11:1166, 1951.Crossref
11.
Hayles, A. B.; Kennedy, R. L. J.; Beahrs, O. H., and Woolner, L. B.:  Carcinoma of the Thyroid Gland in Children ,  A.M.A.J. Dis. Child. 90:705, 1955.
12.
Buxton, R. W.:  Thyroid Disease in Childhood ,  South. M.J. 50:1175, 1957.Crossref
13.
Uhlmann, E. M.:  Cancer of the Thyroid and Irradiation ,  J.A.M.A. 161:504, 1956.Crossref
14.
Duffy, B. J., Jr.:  Can Radiation Cause Thyroid Cancer?  J. Clin. Endocrinol. 17:1383, 1957.Crossref
15.
Cohen, E. A., and Hyman, C.:  Carcinoma of the Thyroid in Children ,  Am. Surgeon 23:240, 1957.
16.
Doniach, I.:  The Effect of Radioactive Iodine Alone and in Combination with Methylthiouracil upon Tumour Production in the Rat's Thyroid Gland ,  Brit. J. Cancer 7:181, 1953.Crossref
17.
Frantz, V. K.; Kligerman, M. M.; Harland, W. A.; Phillips, M. E., and Quimby, E. H.:  A Comparison of the Carcinogenic Effect of Internal and External Irradiation on the Thyroid Gland of the Male Long-Evans Rat ,  Endocrinology 61:574, 1957.Crossref
18.
Doniach, I.:  Sensitivity of the Weanling Rat Thyroid to Radiation ,  Brit. J. Cancer 11:253, 1957.Crossref
19.
Simpson, C. L.; Hempelmann, L. H., and Fuller, L. M.:  Neoplasia in Children Treated with X-Rays in Infancy for Thymic Enlargement ,  Radiology 64:840, 1955.Crossref
20.
Winship, T.:  Carcinoma of the Thyroid in Childhood ,  Pediatrics 18:459, 1956.
21.
Quimby, E. H., and Werner, S. C.:  Late Radiation Effects in Roentgen Therapy for Hyperthyroidism: Their Possible Bearing on the Use of Radioactive Iodine ,  J.A.M.A. 140:1046, 1949.Crossref
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