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Article
March 1960

Relationship of Viruses to Malignant Disease: Part I. Tumor Induction by SE Polyoma Virus

Author Affiliations

Buffalo

Roswell Park Memorial Institute, Buffalo.

AMA Arch Intern Med. 1960;105(3):469-481. doi:10.1001/archinte.1960.00270150123012
Abstract

The discovery of viruses by Iwanowski1 in 1892 and its confirmation by Beijerinick 2 in 1899 led the two French investigators Borrel 3,4 and Boss 5 to postulate that some tumors may be caused by viruses. The first report of a tumor-inducing virus was made in 1908 by Ellerman and Bang 6 who discovered the virus of chicken leukosis. Three years later, Rous 7,8 discovered the viruses causing chicken sarcoma and osteochondrosarcoma.

In 1932, Shope 9,10 found that a fibroma in rabbits was caused by a virus, and discovered a virus causing infectious papilloma in rabbits. The following year, Furth11 classified chicken leukosis as erythroblastosis and myeloblastosis, and showed that it was transmissible by cell-free filtrates. In 1936, Bittner 12 made his fundamental discovery of the virus that induces mammary tumors in mice. Two years later, Lucké 13 demonstrated the viral etiology for a kidney carcinoma in the

References
1.
Iwanowski, D.:  Über die Mosaikkrankheit der Tabakspflanze ,  Z. Planzenkr. 12:1, 1903.
2.
Beijerinick, M. N.:  Über ein Contagium vivum fluidum als Ursache der Fleckenkrankheit der Tabaksblaetter ,  Zentralbl. Bakt. 2:27, 1899.
3.
Borrel, A.:  Epithelioses infectieuses et epitheliomas ,  Ann. Inst. Pasteur 17:81-122, 1903.
4.
Borrel, A.:  Le Probleme du cancer ,  Bull. Inst. Pasteur 5:497, 593, 641, 1907.
5.
Boss, F. J.:  Les Epitheliomas parasitairs laclaveles et l'epithelioma claveleus ,  Zentralbl. Bakt. Abst. I. Orig. 34:413, 517, 666, 1903.
6.
Ellerman, V., and Bang. O.:  Experimentelle Leukaemia bei Hühnern ,  Zentralbl. Bakt. 46:595, 1908.
7.
Rous, P.:  Transmission of a Malignant New Growth by Means of a Cell-Free Filtrate ,  J.A.M.A. 56:198, 1911.
8.
Rous, P.; Murphy, J. B., and Tytler, W. H.:  A Filterable Agent in the Cause of a Second Chicken Tumor, An Osteochondro-Sarcoma ,  J.A.M.A. 59:1793, 1912.Crossref
9.
Shope, R. E.:  A Transmissible Tumor-like Condition in Rabbits ,  J. Exper. Med. 56:793, 1932.Crossref
10.
Shope, R. E.:  Infectious Papillomatosis of Rabbits with a Note on Histopathology by E. W. Hurst ,  J. Exper. Med. 58:607, 1933.Crossref
11.
Furth, J.:  Lymphomatosis, Myelomatosis and Endothelioma of Chickens Caused by a Filtrate Agent ,  J. Exper. Med. 58:253, 1933.Crossref
12.
Bittner, J. J.:  Some Possible Effects of Nursing on the Mammary Gland Tumor Incidence in Mice ,  Science 84:162, 1936.Crossref
13.
Lucke, B.:  Carcinoma in the Leopard Frog: Its Probable Causation by a Virus ,  J. Exper. Med. 68:457, 1938.Crossref
14.
Duran-Reynals, F., and Thomas, R. M.:  A Hemorrhagic Disease Occurring in Chicks Inoculated with the Rous and Fujinami Viruses ,  Yale J. Biol. & Med. 13:77, 1940.
15.
Byran, W. R., and Beard, J. W.:  Studies on the Purification and Properties of the Rabbit Papilloma Virus Protein ,  J. Nat. Cancer Inst. 1:607, 1941.
16.
Burmester, B. R.:  Studies on the Fowl Lymphomatosis ,  Ann. New York Acad. Sc. 54: 992, 1952.
17.
Gross, L.:  "Spontaneous" Leukemia Developing in C3H Mice Following Inoculation in Infancy with AK-Leukemic Extracts, or AK-Embryos ,  Proc. Soc. Exper. Biol. & Med. 76:27, 1951.
18.
Gross, L.:  Pathogenic Properties and Vertical Transmission of the Mouse Leukemia Agent ,  Proc. Soc. Exper. Biol. & Med. 78:342, 1951.
19.
Gross, L.:  Studies on the Nature and Biological Properties of a Transmissible Agent Causing Leukemia Following Inoculation into Newborn Mice ,  Ann. New York Acad. Sc. 68:501, 1957.
20.
Stewart, S. E.:  Leukemia in Mice Produced by a Filterable Agent in AKR Leukemic Tissue with Notes on a Sarcoma Produced by the Same Agent ,  Anat. Rec. 117:532, 1953.
21.
Gross, L.:  Viral Etiology of "Spontaneous" Mouse Leukemia: A Review ,  Cancer Res. 18:371, 1958.
22.
Law, L. W.; Dunn, T. B., and Boyle, D. J.:  Neoplasms in C3H Strain and in F1 Hybrid Mice of 2 Crosses Following Introduction of Extracts and Filtrates of Leukemic Tissues ,  J. Nat. Cancer Inst. 16:495, 1955.
23.
Stewart, S. E.:  Neoplasms in Mice Inoculated with Cell-Free Extracts or Filtrates of Leukemic Mouse Tissues: I. Neoplasms of the Parotid and Adrenal Glands ,  J. Nat. Cancer Inst. 15:1391, 1955.
24.
Stewart, S. E.; Eddy, B. E.; Gochenour, A. M.; Borgese, N. G., and Grubbs, A. G.:  The Induction of Neoplasms with a Substance Released from Mouse Tumors by Tissue Culture ,  Virology 3:380, 1957.Crossref
25.
Stewart, S. E.; Eddy, B. E.; Haas, C. H., and Borgese, N. G.:  Lymphocytic Choreomeningitis Virus as Related to Chemotherapy Studies and to Tumor Induction in Mice ,  Ann. New York Acad. Sc. 68:419, 1957.Crossref
26.
Eddy, B. E.; Stewart, S. E.; Young, R., and Mider, G. B.:  Neoplasms in Hamsters Induced by Mouse Tumor Agent Passed in Tissue Culture ,  J. Nat. Cancer Inst. 20:747, 1958.
27.
Eddy, B. E., and Stewart, S. E.:  Physical Properties and Hemagglutinating and Cytopathogenic Effects of the SE Polyoma Virus ,  Canad. Cancer Conf. 3:307, 1959.
28.
Stewart, S. E.; Eddy, B. E., and Stanton, M. F.:  Induction of Neoplasms in Mice and Other Mammals by a Tumor Agent Carried in Tissue Culture ,  Canad. Cancer Conf. 3:287, 1959.
29.
Stewart, E.; Eddy, B. E., and Stanton, Lee S. L.:  Tissue Culture Plaques of SE Polyoma Virus ,  Proc. Am. Cancer Res. 3:67, 1959.
30.
Induction by Virus-like Agent(s), Canad. Cancer
31.
Mirand, E. A.; Mount, D. T.; Moore, G. E.; Grace, J. T., Jr., and Sokal, J. E.:  Induction of Tumors by Virus-like Agent(s) Released by Tissue Culture ,  Proc. Soc. Exper. Biol. & Med. 99:1, 1958.
32.
Schwartz, S. O.; Schoolman, H. M., and Szanto, P. B.:  Studies in Leukemia: IV. The Acceleration of the Development of AKR Lymphoma by Means of Cell-Free Filtrates ,  Cancer Res. 16:559, 1956.
33.
Schwartz, S. O.; Schoolman, H. M.; Spurrier, W., and Yates, L.:  Studies in Leukemia: VIII. Leukemogenic Effect of Brain Filtrates after Serial Passages Through Mice ,  Proc. Soc. Exper. Biol. & Med. 97:397, 1958.
34.
Friend, C. J.:  Cell-Free Transmission in Adult Swiss Mice of a Disease Having the Character of a Leukemia ,  J. Exper. Med. 105:307, 1957.
35.
Friend, C. J.:  A Virus-Induced Leukemia of Adult Mice , in  Perspectives in Virology , New York, John Wiley & Sons, Inc., 1959, p. 231.
36.
Graffi, A.:  Chloroleukemia of Mice ,  Ann. New York Acad. Sc. 68:540, 1957.
37.
Mirand, E. A., and Moore, G. E.:  Tumor Induction by Virus-like Agent(s) ,  Canad. Cancer Conf. 3:325, 1959.
38.
Mirand, E. A.; Grace, J. T., and Sokal, J. E.:  The Transplantability of Tumors Induced by the SE Polyoma Virus ,  Anat. Rec. 134:608, 1959.
39.
Eddy, B. E.; Stewart, S. E., and Berkeley, W.:  Cytopathogenicity in Tissue Cultures by Tumor Virus from Mice ,  Proc. Soc. Exper. Biol. & Med. 98:848, 1958.
40.
Rowe, W. P.; Hartley, J. W.; Estes, J. D., and Huebner, R. J.:  Studies of Mouse Polyoma Virus Infection: I. Procedure for Quantitation and Detection of Virus ,  J. Exper. Med. 109:379, 1959.
41.
Kahler, H.; Rowe, W. P.; Lloyd, B. J., and Hartley, J. W.:  Electron Microscopy of Mouse Parotid Tumor (Polyoma) Virus ,  J. Nat. Cancer Inst. 22:647, 1959.
42.
Bernhard, W.; Febvre, H. L., and Cramer, R.:  Mise en évidence au microscope electronique d'un Virus dans des cellules infectées in vitro par l'agent du polyoma ,  Compt. rend. Acad. sc. 249: 483, 1959.
43.
Burmester, B. R., and Cottral, G. E.:  The Propagation of Filterable Agents Producing Lymphoid Tumors and Osteopetrosis by Serial Passage in Chickens ,  Cancer Res. 7:669, 1947.
44.
Eckert, E. A.; Beard, D., and Beard, J. W.:  Dose-Response Relations in Experimental Transmission of Avian Erythromyeloblastic Leukosis: V. Influence of Host Age and Route of Virus Inoculation ,  J. Nat. Cancer Inst. 15:1195, 1955.
45.
Beaudreau, G. S.; Bonar, R. A.; Beard, D., and Beard, J. W.:  Virus of Avian Erythroblastosis: II. Influence of Host Age and Route of Inoculation on Dose-Response ,  J. Nat. Cancer Inst. 17:91, 1956.
46.
Gottschalk, R. J.:  Factors Influencing the Stability of a Filterable Agent of Chicken Leukosis and Sarcoma ,  Cancer Res. 6:270, 1946.
47.
Bryan, W. R.:  Biological Studies on the Rous Sarcoma: I. General Introduction; II. Review of Sources of Experimental Variation and of Methods for Their Control ,  J. Nat. Cancer Inst. 16:285, 1955.
48.
Harris, R. J. C.:  Acquired Tolerance of Turkeys to Rous Sarcoma Agent ,  Proc. Roy. Soc. London, Ser. B 146:59, 1956.Crossref
49.
Sachs, L.; Fogel, M., and Winocour, E.:  In Vitro Analysis of a Mammalian Tumour Virus ,  Nature, London 183:663, 1959.Crossref
50.
Dulbecco, R., and Freeman, G.:  Plaque Production by the Polyoma Virus ,  Virology 8:396, 1959.Crossref
51.
Rowe, W. P.; Hartley, J. W.; Brodsky, I.; Huebner, R. J., and Law, L. W.:  Observations on the Spread of Mouse Polyoma Virus Infection ,  Nature, London 182:1617, 1958.Crossref
52.
Lieberman, M., and Kaplan, H. S.:  Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice ,  Science 130: 387, 1959.Crossref
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