[Skip to Content]
[Skip to Content Landing]
Article
June 1960

I131 Triolein Tolerance Curves in Patients with Diabetes Mellitus: Their Similarity to Those Observed in Myocardial Infarction

Author Affiliations

Philadelphia With the Technical Assistance of Miss Jean Schraeder

From the Division of Cardiology, Philadelphia General Hospital.; Chief, Radioisotope Section (Dr. Sandberg); Resident (Dr. Min); Chief, Chemical Research Laboratory (Dr. Feinberg), Division of Cardiology, Philadelphia General Hospital. Director, Division of Cardiology, Philadelphia General Hospital, and Director, Division of Cardiovascular Disease, Graduate Hospital of the University of Pennsylvania (Dr. Bellet).

AMA Arch Intern Med. 1960;105(6):866-872. doi:10.1001/archinte.1960.00270180044006
Abstract

When Thannhauser and Stanley1,2 fed I131-labeled olive oil and followed the appearance and disappearance of the radioactivity in the blood of their patients, they introduced a new, simple, and very valuable technique for the study of neutral fat metabolism in health and disease. Numerous reports soon followed3-6 in which I131-labeled neutral fat was used as a diagnostic tool in various malabsorptive syndromes. The fruitfulness of this field of investigation probably led to a delay in the use of this technique in studying hyperlipemic states, although the original workers reported abnormal curves in nephrotics and idiopathic hyperlipemia as well.1,2 Recent studies by others as well as in our laboratory 7-9 have demonstrated that individuals with proven myocardial infarction display elevated levels of blood radioactivity following ingestion of a radioactively labeled fat meal. Since it is well known that patients with diabetes mellitus have a tendency to develop atherosclerotic lesions at an

References
1.
Thannhauser, S. J., and Stanley, M. M.:  Serum Fat Curves Following Oral Administration of I-131 Labelled Neutral Fat to Normal Subjects and Those with Idiopathic Hyperlipemia ,  Tr. A. Am. Physicians 62:245, 1949.
2.
Stanley, M. M., and Thannhauser, S. J.:  The Absorption and Disposition of Orally Administered I-131 Labelled Neutral Fat in Man ,  J. Lab. & Clin. Med. 34:1634, 1949.
3.
Ruffin, J. M.; Shingleton, W. W.; Baylin, G. J.; Hymans, J. C.; Isley, J. K.; Sanders, A. R., and Sohmer, M. F.:  I-131 Labelled Fat in the Study of Intestinal Absorption ,  New England J. Med. 255:594, 1956.
4.
Beres, P.; Wenger, J., and Kirsner, J. B.:  The Use of I-131 Triolein in the Study of Absorptive Disorders in Man ,  Gastroenterology , 32:1, 1957.
5.
Berkowitz, D., and Sklaroff, D.:  The Use of Radioactive Fat in the Study of Absorption in Various Disease States ,  A.M.A. Arch. Int. Med. 100:951, 1957.
6.
Turner, D. A.:  The Absorption, Transport and Deposition of Fat: Application of a New Method for the Determination of I-131 Lipid Activity in Dogs and Man; Pt. 1 and Pt. 2 ,  Am. J. Digest. Dis. 3:594, 682, 1958.
7.
Seller, R. H.; Brachfeld, J.; Sandberg, H., and Bellet, S.:  The Use of I-131 Labelled Fat in the Study of Lipid Handling in Patients with Coronary Artery Disease ,  Am. J. Med. 27:231, 1959.
8.
Likoff, W.; Berkowitz, D.; Woldow, A.; Jacobs, A. G., and Sklaroff, D.:  Radioactive Fat Absorption Patterns: Their Significance in Coronary Artery Atherosclerosis ,  Circulation 18:1118, 1958.
9.
Berkowitz, D.; Sklaroff, D.; Woldow, A.; Jacobs, A. G., and Likoff, W.:  Blood Absorptive Patterns of Isotopically-Labeled Fat and Fatty Acid ,  Ann. Int. Med. 50:247, 1959.
10.
New York Heart Association, Inc.:  Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Blood Vessels , Ed. 5, New York, American Heart Association, 1953.
11.
Abell, L. L.; Levy, B. B.; Brodie, B. B., and Kendall, F. E.:  A Simplified Method for the Estimation of Total Cholesterol in Serum and Demonstration of Its Specificity ,  J. Biol. Chem. 195:357, 1952.
12.
Youngburg, G. E., and Youngburg, M. V.:  Phosphorus Metabolism: I. A System of Blood Phosphorus Analysis ,  J. Lab. & Clin. Med. 16:158, 1930.
13.
Van Handel, E., and Zilversmit, D. B.:  Micromethod for the Direct Determination of Serum Triglycerides ,  J. Lab. & Clin. Med. 50:152, 1957.
14.
Fredrickson, D. S., and Gordon, R. S., Jr.:  Transport of Fatty Acids ,  Physiol. Rev. 38:585, 1958.
15.
Gray, H.:  Lipids in 1,000 Diabetic Bloods with Special Regard to Prognosis ,  Am. J.M. Sc. 168:35, 1924.
16.
Man, E. B., and Peters, J. P.:  Serum Lipids in Diabetes ,  J. Clin. Invest. 14:579, 1935.
17.
Pomeranze, J., and Kumkel, H. G.:  Serum Lipids in Diabetes Mellitus ,  Proc. Am. Diabetic A . 10:217, 1950.
18.
Barr, D. P.; Russ, E. M., and Eder, H. A.:  Protein-Lipid Relationships in Human Plasma: II. In Atherosclerosis and Related Conditions ,  Am. J. Med. 11:480, 1951.
19.
Harris, L. V.; Albrink, M. J.; Van Eck, W. F.; Man, E. B., and Peters, J. P.:  Serum Lipids in Diabetic Acidosis ,  Metabolism 2:120. 1953.
20.
Blix, G.:  Diabetic Lipemia ,  Acta med. scandinav. 64:142, 1926.
21.
Waddell, W. R., and Geyer, R. P.:  Effect of Insulin on Clearance of Emulsified Fat from the Blood in Depancreatized Dogs ,  Proc. Soc. Exper. Biol. & Med. 96:251, 1957.
22.
Bierman, E. L.; Dole, V. P., and Roberts, T. N.:  An Abnormality of Nonesterified Fatty Acid Metabolism in Diabetes Mellitus ,  Diabetes 6:475, 1957.
23.
Dole, V. P.:  Fat Metabolism in Diabetes .  Bull. N.Y. Acad. Med. 34:21, 1958.
24.
Rony, H. R., and Ching, T. T.:  Studies on Fat Metabolism: Effects of Certain Hormones on Fat Transport ,  Endocrinology 14:355, 1930.Crossref
25.
Rubin, L., and Aladjem, F.:  Serum Lipoprotein Changes During Fasting in Man ,  Am. J. Physiol. 178:263, 1954.
26.
Albrink, M. J.; Fitzgerald, J. R., and Man, E. B.:  Effect of Glucagon on Alimentary Lipemia ,  Proc. Soc. Exper. Biol. & Med. 95:778, 1957.
27.
Albrink, M. J.; Fitzgerald, J. R., and Man, E. B.:  Reduction of Alimentary Lipemia by Glucose ,  Metabolism 7:162, 1958.
28.
Albrink, M. J., and Man, E. B.:  Effect of Carbohydrate Ingestion on Post-Prandial Lipemia ,  Am. J. Digest. Dis. 2:649, 1957.
29.
Bragdon, J. H., and Gordon, R. S., Jr.:  Tissue Distribution of C" After the Intravenous Injection of Labeled Chylomicrons and Unesterified Fatty Acids in the Rat ,  J. Clin. Invest. 37: 574, 1958.
30.
White, N. K.; Edwards, J. E., and Dry, T. J.:  The Relationship of the Degree of Coronary Atherosclerosis with Age in Men ,  Circulation 1:645, 1950.
31.
Gofman, J. W.; Glazier, F.; Tamplin, A.; Strisower, B., and DeLalla, O.:  Lipoproteins, Coronary Heart Disease and Atherosclerosis ,  Physiol. Rev. 34:589, 1954.
32.
Necheles, H.; Meyer, J., and Becker, G. H.:  Fat Absorption and Atherosclerosis: A Theory on the Development of Atherosclerosis with Aging ,  Am. Heart J. 38:472, 1949.
33.
Ackermann, P. G.; Toro, G.; Toro, J.; Kheim, T., and Kountz, W. B.:  Blood Lipids in Young and Old Individuals ,  Clin. Chem. 5:100, 1959.
×