[Skip to Content]
[Skip to Content Landing]
July 1960

Postnecrotic Cirrhosis Without Antecedent Acute Liver Disease

Arch Intern Med. 1960;106(1):71-80. doi:10.1001/archinte.1960.03820010073012

Postnecrotic cirrhosis is considered, in the United States, almost always to be a residual of infectious or homologous serum hepatitis, although in occasional instances, exposure to toxic chemicals may be blamed.1 In the tropics, malnutrition is believed to be an important etiologic factor. Whatever the basic cause, all appear to have in common the ability to produce the diffuse hepatocellular necrosis required in the pathogenesis of postnecrotic cirrhosis.

During and since World War II, there has been a high incidence of hepatitis throughout the world. This has stimulated great interest in the possible residuals of that disease. In our experience and in that of others,2,3 there also has recently been an increase in the frequency of postnecrotic cirrhosis, and it is natural to associate the two conditions. There have been, however, a number of patients in whom postnecrotic cirrhosis appears to have developed de novo.4,5 Not only

Ratnoff, O. D.:  Posthepatic Cirrhosis ,  J.A. M.A. 165:1096-1098, 1957.Crossref
MacDonald, R. A.:  Cirrhosis and Primary Carcinoma of Liver: Changes in Their Occurrence at the Boston City Hospital, 1897-1954 ,  New England J. Med. 255:1179-1183, 1956.Crossref
MacDonald, R. A.:  Primary Carcinoma of the Liver: A Clinicopathological Study of 108 Cases ,  A.M.A. Arch. Int. Med. 99:266-279, 1957.Crossref
Ratnoff, O. D., and Patek, A. J., Jr.:  Hepatitis and Cirrhosis of the Liver ,  Medicine 21:207-212, 1942.
Ratnoff, O. D., and Patek, A. J., Jr.:  Postnecrotic Cirrhosis of the Liver: A Study of 45 Cases ,  J. Chron. Dis. 1:266-291, 1955.Crossref
Jones, C. M., and Minot, G. R.:  Infectious (Catarrhal) Jaundice: An Attempt to Establish a Clinical Entity ,  Boston M. & S.J. 189:531-551, 1923.
Roholn, K., and Iverson, P.:  Changes in the Liver in Acute Epidemic Hepatitis Based on 38 Aspiration Biopsies ,  Acta path. et microbiol. scandinav. 16:427-442, 1939.
Barzelatto, J.: Caracteres anatomo clinicos y sistematizacion de las cirrhosis hepaticos, Thesis, 1950.
Bjorneboe, J., and Raschou, F.:  Pathology of Subchronic Atrophy of the Liver ,  Arch. Int. Med. 84:933-944, 1949.
Jersild, M.:  Infectious Hepatitis with Subacute Atrophy of the Liver ,  New England J. Med. 231:315-320, 1944.
Kunkel, H. G.:  Chronic Liver Disease Following Infectious Hepatitis: II. Cirrhosis of the Liver ,  Ann. Int. Med. 32:433-450, 1950.
Lucke, B.:  The Pathology of Fatal Epidemic Hepatitis ,  Am. J. Path. 20:471-487, 1944.
Cullinan, E. R.:  Idiopathic Jaundice, Often Recurrent, Associated with Subacute Necrosis of the Liver ,  St. Barth. Hosp. J. 69:55-142, 1936.
Bloomfield, A. L.:  Natural History of Chronic Hepatitis (Cirrhosis of the Liver) ,  Am. J.M. Sc. 195:429-444, 1938.
Klatskin, G., and Rappaport, E. M.:  Late Residuals in Presumably Cured Infectious Hepatitis ,  Ann. Int. Med. 26:13-25, 1947.
Kornberg, A.:  Latent Liver Disease in Persons Recovered from Catarrhal Jaundice and in Otherwise Normal Medical Students as Revealed by the Bilirubin Excretion Test ,  J. Clin. Invest. 21: 299-308, 1942.
Marion, D. G.:  Delayed Convalescence Following Acute Hepatitis: Clinical and Laboratory Evaluation ,  Gastroenterology 8:717-727, 1947.
Neefe, J. R.:  Results of Hepatic Tests in Chronic Hepatitis Without Jaundice: Correlation with the Clinical Course and Liver Biopsy Findings ,  Gastroenterology 7:1-13, 1946.
Neefe, J. R.:  Chronic Hepatitis in Volunteers , in  Transactions of the Conference on Liver Injury 5:90-97, 1946.
Watson, C. J., and Hoffbauer, F. W.:  The Problem of Prolonged Hepatitis with Particular Reference to the Cholangiolitic and to the Development of Cholangiolitic Cirrhosis of the Liver ,  Ann. Int. Med. 25:195-227, 1946.
Smetana, H. F.:  Histogenesis of Coarse Nodular Cirrhosis ,  Lab. Invest. 5:175-193, 1956.
Zieve, L.; Hill, E.; Nesbitt, S., and Zieve, B.:  Incidence of Residuals of Viral Hepatitis ,  Gastroenterology 25:495-531, 1953.
Snell, A. M.:  Presidential address ,  Gastroenterology 24:467-475, 1953.
MacDonald, R. A., and Mallory, G. K.:  The Natural History of Postnecrotic Cirrhosis ,  Am. J. Med. 24:334-357, 1958.Crossref
Klatskin, G.:  Subacute Hepatic Necrosis and Postnecrotic Cirrhosis Due to Anicteric Infections with the Hepatitis Virus ,  Am. J. Med. 25:333-358, 1958.Crossref
Damodaran, K.:  Infective Hepatitis and Portal Cirrhosis ,  Brit. M.J. 1:1032-1040, 1949.Crossref
Brick, I. B.:  Residuals of Yellow Fever Vaccine After 10 Years ,  A.M.A. Arch. Int. Med. 92:221-227, 1953.Crossref
Popper, H., and Schaffner, F.:  Liver: Structure and Function , New York, McGraw-Hill Company, Inc., 1957.
Popper, H.:  Transition of Hepatitis into Cirrhosis ,  Am. J. Digest. Dis. 2:397-404, 1957.Crossref