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Article
July 1960

Irreversible Renal Failure Following Short-Term Therapy in Sarcoidosis

Arch Intern Med. 1960;106(1):112-116. doi:10.1001/archinte.1960.03820010114016
Abstract

Hypercalcemia occurs in certain patients with sarcoidosis. The cause is not clearly defined. The studies of Henneman et al.1 suggest that the hypercalciuria of sarcoid may result from an excess endogenous source of vitamin D. Accordingly, sarcoid patients might exhibit unusual susceptibility to calciferol.

Curtis et al.,2 Robertson,3 and Nelson4 have shown that many patients with sarcoidosis are intolerant of large doses of vitamin D and, under such treatment, rapidly develop hypercalcemia. Harrell and Fischer5 reported one instance in which there was a rise in serum calcium from 9.6 to 14.2 mg. % when one pint of cod liver oil was ingested monthly.

This report presents a case of sarcoid in which irreversible renal damage occurred after administration of 1,200,000 units of vitamin D over an eight-day period. Ectopic calcification, renal calculi, and nephrocalcinosis appeared as complications. Steroid therapy was effective in reducing the ectopie calcium deposited, but there was

References
1.
Henneman, P. H.; Dempsey, E. F.; Carroll, E. L., and Albright, F.:  The Cause of Hypercalcuria in Sarcoid and Its Treatment with Cortisone and Sodium Phytate ,  J. Clin. Invest. 35:1229-1242 ( (Nov.) ) 1956.Crossref
2.
Curtis, A. C.; Taylor, H., and Grekin, R. H.:  Sarcoidosis: Results of Treatment with Varying Amounts of Calciferol and Dihydrotachysterol ,  J. Invest. Dermat. 9:131-150 ( (Sept.) ) 1947.Crossref
3.
Robertson, R. F.:  Vitamin D in Treatment of Boeck's Sarcoidosis ,  Brit. M.J. 2:1059-1061 ( (Dec. 18) ) 1948.Crossref
4.
Nelson, C. T.:  Calciferol in Treatment of Sarcoidosis ,  J. Invest. Dermat. 13:81-84 ( (Aug.) ) 1949.Crossref
5.
Harrell, G. T., and Fischer, S.:  Blood Chemical Changes in Boeck's Sarcoidosis with Particular Reference to Protein, Calcium and Phosphatase Values ,  J. Clin. Invest. 18:687-693 ( (Nov.) ) 1939.Crossref
6.
Carlsson, A., and Lindquist, B.:  Comparison of Intestinal and Skeletal Effects of Vitamin D in Relation to Dosage ,  Acta physiol. scandinav. 35:53-55, 1955.Crossref
7.
Gilg, I.:  Preliminary Experiences with Vitamin D2 in Treatment of Sarcoid of Boeck ,  Ugesk laeger 111:1281-1285 ( (Nov. 17) ) 1949.
8.
Scadding, J. G.:  Sarcoidosis (Bradshaw Lecture) ,  Brit. M.J. 1:745-753 ( (April 1) ) 1950.Crossref
9.
Steck, I. E.:  Clinical Experience in Treatment of Arthritis with Massive Doses of Vitamin D ,  Illinois M.J. 71:243-248 ( (March) ) 1937.
10.
Steinberg, C. L.:  Massive Doses of Vitamin D in Chronic Arthritis; Its Effect on Calcium Metabolism ,  J. Lab. & Clin. Med. 24:17-24 ( (Oct.) ) 1938.
11.
Larson, L.-G.; Liljestrand, A., and Wahlund, H.:  Treatment of Sarcoidosis with Calciferol ,  Acta med. scandinav. , 143:281-287, 1952.
12.
Harrison, T. R., and others, Editors:  Principles of Internal Medicine , Ed. 2, New York, The Blakiston Company (division of McGraw-Hill Book Company, Inc.), 1954.
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