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Article
December 1960

Intrathoracic Plasmacytoma: Report of a Case and Review of the Literature

Author Affiliations
Salt Lake City
From the Veterans Administration Hospital and Department of Medicine of the University of Utah College of Medicine, Salt Lake City.
Arch Intern Med. 1960;106(6):862-869. doi:10.1001/archinte.1960.03820060114013
Abstract

The common diagnostic possibilities when a mediastinal or hilar mass is discovered in the absence of parenchymal pulmonary disease can be divided into diseases of mediastinal structures and diseases of lymph nodes. The former group includes benign cysts, dermoid cysts, teratomas, tumors of the thyroid and thymus, and tumors of neural origin and of connective tissue.1 The common causes of hilar or mediastinal lymph node enlargement are granulomas, lymphomas, and metastatic carcinoma, while reactive hyperplasia, erythema nodosum, sarcoidosis, and leukemia virtually comprise the less common causes. Plasma-cell tumors of the hilar nodes are unusual members of this latter group.

The discovery of a plasma-cell tumor in a large hilar node of an asymptomatic 47-year-old man provoked this review of the life history and significance of extramedullary plasma-cell tumors located within the chest, and particularly of their relationship to multiple myeloma.

Report of Case  A 47-year-old white laborer was admitted

References
1.
Blades, B.:  Mediastinal Tumors: Report of Cases Treated at Army Thoracic Surgery Centers in the United States ,  Ann. Surg. 123:749, 1946.Crossref
2.
Maximow, A. A., and Bloom, W.:  A Textbook of Histology , Ed. 5, Philadelphia, W. B. Saunders Company, 1948, pp. 63, 109.
3.
Voegt, H.:  Extramedulläre Plasmocytome ,  Arch. path. Anat. 302:497, 1938.Crossref
4.
Azar, H. A.; Hill, W. T., and Osserman, E. F.:  Malignant Lymphoma and Lymphatic Leukemia Associated with Myeloma-Type Serum Proteins ,  Am. J. Med. 23:239, 1957.Crossref
5.
Inada, K.; Kawai, K.; Katsumura, T., and Nakano, A.:  Giant Lymph Node Hyperplasia of the Mediastinum ,  Am. Rev. Tuberc. 79:232, 1959.
6.
Castleman, B.; Iverson, L., and Pardo Menendez, V.:  Localized Mediastinal Lymph-Node Hyperplasia Resembling Thymoma ,  Cancer 9:822, 1956.Crossref
7.
Hellwig, C. A.:  Extramedullary Plasma Cell Tumors as Observed in Various Locations ,  Arch. Path. 36:95, 1943.
8.
King, B. B.:  Solitary Plasma Cell Myeloma of Bone as an Initial Stage of Multiple Myeloma ,  J.A.M.A. 115:36, 1940.Crossref
9.
Paul, L. W., and Pohle, E. A.:  Solitary Myeloma of Bone ,  Radiology 35:651, 1940.Crossref
10.
Gootnick, L. T.:  Solitary Myeloma: Review of 61 Cases ,  Am. J. Roentgenol. 45:385, 1945.
11.
Carson, C. P.; Ackerman, L. V., and Maltby, J. D.:  Plasma Cell Myeloma ,  Am. J. Clin. Path. 25:849, 1955.
12.
Jackson, H., Jr.; Parker, F., Jr., and Bethea, J. M.:  Studies of Diseases of the Lymphoid and Myeloid Tissues: II. Plasmacytomata and Their Relationship to Multiple Myeloma ,  Am. J.M. Sc. 181:169, 1931.Crossref
13.
Klose, H.:  Über das plasmacytom der pleura ,  Beitr. klin. Chir. 74:20, 1911.
14.
Diviš, G., and S̆ikl, H.:  Über erfolgreiche operative Entfernung einer eigenartigen Lungengeschwulst (Plasmozytom) ,  Acta chir. scandinav. 63:207, 1928.
15.
Bross, K.:  Zur Plasmozytomfrage ,  Folia haemat. 45:137, 1931.
16.
Gordon, J., and Walker, G.:  Plasmacytoma of the Lung ,  Arch. Path. 37:222, 1944.
17.
Childress, W. G., and Adie, G. C.:  Plasma Cell Tumors of the Mediastinum and Lung ,  J. Thoracic Surg. 19:794, 1950.
18.
Lane, J. D.; Krohn, S.; Kolozsi, W., and Whitehead, R. E.:  Plasma Cell Granuloma of the Lung ,  Dis. Chest 27:216, 1955.Crossref
19.
Kuley, M., and Kuntman, O.:  A Case of Plasmacytoma of the Lung ,  Dis. Chest 19:227, 1951.Crossref
20.
Cotton, B. H., and Penido, J. R. F.:  Plasma Cell Tumors of the Lung ,  Dis. Chest 21:218, 1952.Crossref
21.
Hill, L. D., III, and White, M. L., Jr.:  Plasmacytoma of the Lung ,  J. Thoracic Surg. 25: 187, 1953.
22.
Ackerman, L. V.:  Surgical Pathology , St. Louis, The C. V. Mosby Company, 1953, p. 208.
23.
Rozsa, S., and Frieman, H.:  Extramedullary Plasmacytoma of the Lung ,  Am. J. Roentgenol. 70:982, 1953.
24.
Spyker, M. A., and Kay, S.:  Plasma Cell Granuloma of a Mediastinal Lymph Node with Extension to Right Lung ,  J. Thoracic Surg. 31: 211, 1956.
25.
Robson, A. O., and Knudsen, A.:  Plasmacytoma of Lung and Stomach ,  Brit. J. Dis. Chest 53:62, 1959.Crossref
26.
Gross, R. E., and Vaughan, W. W.:  Plasma Cell Myeloma ,  Am. J. Roentgenol. 39:344, 1938.
27.
Grant, I. W. B., and Ross, J. D.:  Plasma Cell Tumour of Trachea ,  Brit. J. Tuberc. 52:299, 1958.Crossref
28.
Blumenfeld, L.:  Plasma Cell Tumors of the Nose and Nasopharynx ,  Ann. Otol. Rhin. & Laryng. 45:436, 1936.
29.
Stone, D. J.; Schwartz, M. J., and Green, R. A.:  Fatal Pulmonary Insufficiency Due to Radiation Effect Upon the Lung ,  Am. J. Med. 21:211, 1956.
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