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Article
July 1966

Extended Radiotherapy in Advanced Hodgkin's Disease: Hematologic Aspects

Author Affiliations

BETHESDA, MD

From the Radiation Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Arch Intern Med. 1966;118(1):70-74. doi:10.1001/archinte.1966.00290130072013
Abstract

THE LITERATURE convincingly substantiates the argument that clinically localized Hodgkin's disease, in the absence of constitutional symptoms, is controllable for prolonged periods if not curable by intensive irradiation. The frequency of survival at ten years following treatment is appreciable.1-4 Perhaps more important is the comparability of the survival curve at five and particularly at ten years after therapy 3 to the expected survival curve for the control population. It has also been observed that the clinical pattern of spread is predictable5 with new manifestations of disease showing a tendency to occur in areas immediately adjacent to regions of initial involvement. This has encouraged the so-called prophylactic irradiation of lymphatic sites adjacent to the clinically involved nodes. Although the value of this approach has not yet been confirmed by controlled investigations, there is suggestive merit to the concept in the reported results.2

An obvious extension of the above

References
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Peters, M.V., and Middlemiss, K.C.H.:  A Study of Hodgkin's Disease Treated by Irradiation ,  Amer J Roentgen 79:114-121, 1958.
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Easson, E.C., and Russell, M.H.:  The Cure of Hodgkin's Disease ,  Brit Med J 1:1704-1707, 1963.Crossref
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Lukes, R.J.:  Relationship of Histologic Features to Clinical Stages in Hodgkin's Disease ,  Amer J Roentgen 90:944-955, 1963.
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Scheer, A.C.:  The Course of Stage 1 Malignant Lymphomas Following Local Treatment ,  Amer J Roentgen 90:939-943, 1963.
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Kurohara, S.S., et al:  Eosinophilia After Exposure to Ionizing Radiation ,  Radiat Res 23:357-367, 1964.Crossref
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DeVita, V.T., et al:  Intensive Combination Chemotherapy and X-Irradiation in the Treatment of Hodgkin's Disease ,  Proc Amer Assoc Cancer Res 6:15, 1965.
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Williams, H.M.; Diamond, H.D.; and Craver, L.F.:  The Pathogenesis and Management of Neurological Complications of Patients With Malignant Lymphomas and Leukemias ,  Cancer 11:76-82, 1958.Crossref
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