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October 1966

Generalized Toxoplasmosis Following Renal Transplantation: Report of a Case

Author Affiliations


From the departments of pathology, Peter Bent Brigham Hospital and Harvard Medical School, Boston, and the Toxoplasma Laboratory, Communicable Disease Center, Public Health Service, US Department of Health, Education and Welfare, Atlanta. Dr. Pfeiffer is presently with the Mary Hitchcock Memorial Hospital, Hanover, NH.

Arch Intern Med. 1966;118(4):401-405. doi:10.1001/archinte.1966.00290160101018

ALTHOUGH.LTHOUGH toxoplasmosis is a common asymptomatic protozoan infection, as indicated by the prevalence of antitoxoplasma antibodies among the adult population,1-3 acute toxoplasmosis in normal adults is uncommon.4-8 Indeed, most reported cases have occurred in patients with either leukemia, cancer, or other chronic disease treated with antimetabolites, immunosuppressive agents, or corticosteroids.9-15 This report concerns a patient with chronic renal disease who was placed on an immunosuppressive regimen and who died of acute disseminated toxoplasmosis one month after receiving a renal homotransplant. Serologic studies suggest that primary infection with Toxoplasma gondii occurred at the time of transplantation.

Report of Case  M. C., a 20-year-old man, was admitted to the Peter Bent Brigham Hospital with uermia secondary to chronic glomerulonephritis. He was febrile due to bacterial pneumonia and peritonitis. The infection responded to antibiotics. During the next two months he remained afebrile. His severe, intractible uremia was treated by repeated

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