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Article
January 1969

Pleural Fluid Lactic Acid Dehydrogenase Activity: Value in Diagnosis

Author Affiliations

FRCP(C); Chicago

From the Department of Thoracic Medicine, Cook County Hospital (Drs. Chandrasekhar, Palatao, and Levine); the Department of Biochemistry, Hektoen Institute (Mr. Dubin); and the University of Illinois, Chicago (Dr. Levine). Doctor; Chandrasekhar is currently with the Division of Medicine, Northwestern University, Evanston, Ill.

Arch Intern Med. 1969;123(1):48-50. doi:10.1001/archinte.1969.00300110050008
Abstract

Lactic acid dehydrogenase (LDH) activity and protein content were studied in 80 patients with pleural effusion. Cases were categorized into malignant, infective, and transudative groups. In all of the 29 patients with inflammatory effusion and in 22 out of 24 patients with malignant effusion, pleural fluid LDH levels were above 550 units. In none of the 27 patients with transudative effusions were the LDH levels above 550 units. All malignant and inflammatory effusions had protein content above 3 gm/100 ml. In 19 out of 27 patients with "transudative" effusions, the plural fluid protein content was above 3 gm/100 ml. The results indicate that the pleural fluid LDH activity of 550 units serves better than protein in differentiating exudative effusions from transudative effusions.

References
1.
Asada, M., and Galambos, T.J.:  Clinical Value of Lactic Dehydrogenase Activity in Diagnosis of Malignant Effusion ,  Amer J Dig Dis 7:1001-1005 ( (Nov) ) 1962.Crossref
2.
 Berger Broida Colorimetric Determination of LDH , Sigma Technical Bulletin No. 500, St. Louis: Sigma Chemical Co., 1965.
3.
Wroblewski, F.:  The Clinical Significance of Lactic Dehydrogenase Activity of Effusions ,  Clin Res Proc 5:218, 1957.
4.
Wroblewski, F.:  The Significance of Alterations in Lactic Dehydrogenase Activity of Body Fluids in the Diagnosis of Malignant Tumors ,  Cancer 12: 27-39 ( (Jan-Feb) ) 1959.Crossref
5.
DeTorregrosa, V.M.:  Results of Lactic Dehydrogenase Determinations in Benign and Malignant Effusions ,  Amer J Med Sci 238:552-556 ( (Nov) ) 1959.
6.
Erickson, J.R., and Morales, R.D.:  Clinical Use of Lactic Dehydrogenase ,  New Eng J Med 265:531-534 ( (Sept) ) 1961.Crossref
7.
Erickson, J.R.:  Lactic Dehydrogenase Activity of Effusion Fluids as an Aid to Differential Diagnosis ,  JAMA 176:794-796 ( (June 12) ) 1961.Crossref
8.
Wu, P.C., and Sung, L.J.:  Clinical Study of Lactic Acid Dehydrogenase ,  Gastroenterology 42: 580-587 ( (May) ) 1962.
9.
Carr, T.D., and McGuckin, F.W.:  Chemistry of Pleural Effusion ,  Biochem Clin 4:283-286, 1964.
10.
Stead, E.M.:  Pleural Effusion ,  DM 1:48 ( (Jan) ) 1964.
11.
Kirkeby, K., and Prydz, H.:  Lactic Dehydrogenase Activity in Pleural and Peritoneal Effusions ,  Scand J Clin Lab Invest 11:185-189, 1959.Crossref
12.
Horrocks, E.J., et al:  Lactic Dehydrogenase Activity in the Diagnosis of Malignant Effusions ,  J Clin Path 15:57-61, 1962.Crossref
13.
Brauer, J.M.; West, M.; and Zimmerman, J.H.:  Serum Enzymes in Disease ,  Cancer 16:533-541 ( (April) ) 1963.Crossref
14.
Raabo, E.; Knud, N.; and Rassmussen:  A Study of the Isoenzymes of Lactic Dehydrogenase in Pleural Effusion ,  Scand J Resp Dis 47:150-156, 1966.
15.
Pillay, V.K.G.:  Total Proteins in Serous Fluids in Cardiac Failure ,  S Afr Med J 39:142-143 ( (Feb) ) 1965.
16.
Carr, T.D., and Power, H.M.:  Clinical Value of Measurement of Concentration of Protein in Pleural Fluid ,  New Eng J Med 259:926-927 ( (May 6) ) 1958.Crossref
17.
Levine, H., and Cugell, D.W.:  Blunt-End Needle Biopsy of Pleura and Rib ,  Arch Intern Med 109:516-525 ( (May) ) 1962.Crossref
18.
Goldberg, W.B.; Chakrabarti, S.; and Filipich, R.:  Urinary Lactic Dehydrogenase, Alkaline Phosphatase and Lysozyme in Renal Diseases ,  Canad Med Assoc J 94:1264-1268 ( (June) ) 1966.
19.
Jagt, T., and Larsen, A.O.:  Determination of Lactic Dehydrogenase in Ascitic Fluid From Patients With Malignant Tumours ,  Scand J Clin Lab Invest 12:200-204, 1960.Crossref
20.
Wroblewski, F.; Decker, B.; and Wroblewski, R.:  Activity of LDH in Spinal Fluid ,  Amer J Clin Path 28:269-271 ( (Sept) ) 1957.
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