[Skip to Content]
[Skip to Content Landing]
January 1969

Extranodal Lymphosarcoma of the Left Liver Lobe With Paraproteinemia

Author Affiliations


From the departments of pathology (Drs. Alami; Bowman; and Race) and medicine (Dr. Reese), Baylor University Medical Center, Dallas. Dr. Alami is now with the Department of Clinical Pathology, American University Hospital, Beirut, Lebanon.

Arch Intern Med. 1969;123(1):64-68. doi:10.1001/archinte.1969.00300110066013

The association of gammapathies with lymphomas and related disorders has been increasingly reported.1-9 Cases of extranodal lymphosarcoma are relatively rare, and those originating in the liver, with associated serum M-components, are accordingly more rare. To the best of our knowledge, this latter association has not been reported by others.

The present report is concerned with a case of malignant lymphoma, lymphocytic type, associated with macroglobulinemia and increased IgG, which was recognized during a diagnostic work-up for anemia and an epigastric mass. Light chain typing of the IgM revealed the presence of type L specificity which is less commonly encountered.

Patient Summary  The patient (BUMC 160-342), an 80-year-old white male, retired grocer, was admitted to Baylor University Medical Center on Aug 13, 1967. The patient had been in unusually good health and active, considering his age, until six to eight weeks prior to admission. He began to note the onset

Azar, H.A.; Hill, W.T.; and Osserman, E.F.:  Malignant Lymphoma and Lymphatic Leukemia Associated With Myeloma-Type Serum Proteins ,  Amer J Med 23:239-249 ( (Aug) ) 1957.Crossref
Prasad, A.S., and Block, H.S.:  Macroglobulinemia Secondary to a Lymphosarcoma of the Brain ,  Arch Intern Med 105:316-319 ( (Feb) ) 1960.Crossref
Bachmann, R.:  Simultaneous Occurrence of Two Immunologically Different M-Components in Serum ,  Acta Med Scand 177:593-599 ( (May) ) 1965.Crossref
Hallen, J.:  Discrete Gamma Globulin (M-) Components in Serum: Clinical Study of 150 Subjects Without Myelomatosis ,  Acta Med Scand 181 ( (suppl 462) ): 71-79, 1966.
Krauss, S., and Sokal, J.:  Paraproteinemia in the Lymphomas ,  Amer J Med 40:400-413 ( (March) ) 1966.Crossref
Miller, D.G., and Korngold, L.:  Monoclonal Immunoglobulins in Cancer ,  Med Clin N Amer 50: 667-674 ( (May) ) 1966.
Wood, T.A., and Frenkel, E.P.:  An Unusual Case of Macroglobulinemia ,  Arch Intern Med 119: 631-637 ( (June) ) 1967.Crossref
Dameshek, W.:  Chronic Lymphocytic Leukemia: An Accumulative Disease of Immunologically Incompetent Lymphocytes ,  Blood 29:566-584 ( (April) ) 1967.
Zawadzki, Z.A., and Edwards, G.A.:  M-Components in Immunoproliferative Disorders, Electrophoretic and Immunologic Analysis of 200 Cases ,  Amer J Clin Path 48:418-430 ( (Oct) ) 1967.
Abrams, A.; Cohen, P.P.; and Meyer, O.O.:  The Physical Properties of a Cryoglobulin Obtained From Lymph Nodes and Serum of a Case of Lymphosarcoma ,  J Biol Chem 181:237-245 ( (Nov) ) 1949.
Mellors, R.C., and Korngold, L.:  The Cellular Origin of Human Immunoglobulins (γ2, γ1M γ1A) ,  J Exp Med 118:387-396 ( (Sept) ) 1963.Crossref
Nossal, G.J.V., et al:  Single Cell Studies on 19 S Antibody Production ,  J Exp Med 119:485-501 ( (Nov) ) 1964.Crossref
Pernis, B., and Chiappino, G.:  Identification in Human Lymphoid Tissues of Cells That Produce Group 1 or 2 Gamma-Globulins ,  Immunology 7: 500-506 ( (Sept) ) 1964.
Burtin, P., and Buffe, D.:  Synthesis of Human Immunoglobulins in Germinal Centers of Lymphoid Organs ,  J Immun 98:536-542 ( (March) ) 1966.
Craddock, C.G., et al:  The Immune System, Immunoglobulins, and Some Disorders of the Lymphatic System ,  Ann Intern Med 64:687-708 ( (March) ) 1966.Crossref
Gamble, C.N., and Cutting, H.O.:  The Production of γG-Globulin by Lymphocytes in Chronic Lymphocytic Leukemia: Immunocytologic Investigation of a Case ,  Blood 27:187-198 ( (Feb) ) 1966.
Merler, E., and Rosen, F.S.:  The Gamma Globulins: I. The Structure and Synthesis of the Immunoglobulins (Concluded) ,  New Eng J Med 275:536-542 ( (Sept) ) 1966.Crossref
Cummings, N.A., and Franklin, E.C.:  Atypical γ1A-Globulin With Electrophoretic Properties of an α2-Globulin Occurring in Multiple Myeloma ,  J Lab Clin Med 65:8-17 ( (Jan) ) 1965.
Vaerman, J.P., et al:  Multiple Myeloma With Two Paraprotein Peaks: An Instructive Case ,  J Lab Clin Med 65:18-25 ( (Jan) ) 1965.
Williams, R.C., et al:  Studies of Monoclonal Immunoglobulins (M-Components) in Various Kindreds ,  Ann Intern Med 67:309-327 ( (Aug) ) 1967.Crossref
Seligmann, M.:  Immunoglobulin Abnormalities in Families of Patients With Waldenstrom Macroglobulinemia ,  Amer J Med 43:66-83 ( (July) ) 1967.Crossref
Waldenstrom, J.:  Clinical Diagnosis and Biochemical Findings in Material of 296 Sera With M-Type, Narrow, Globulins ,  Acta Med Scand 170 ( (suppl 367) ):110-119, 1961.Crossref
Nilehn, J.E., and Nilsson, I.M.:  Coagulation Studies in Different Types of Myeloma ,  Acta Med Scand 179 ( (suppl 445) ):194-199, 1966.Crossref
Simpson, J.F.; Leddy, J.P.; and Hare, J.D.:  Listerosis Complicating Lymphoma ,  Amer J Med 43:39-49 ( (July) ) 1967.Crossref
Hallen, J.:  Frequency of "Abnormal" Serum Globulins (M-Components) in the Aged ,  Acta Med Scand 173:737-744, 1963.Crossref
Axelsson, U.; Bachmann, R.; and Hallen J.:  Frequency of Pathological Proteins (M-Components) in 6,995 Sera From an Adult Population ,  Acta Med Scand 179:235-247, 1966.Crossref
Zawadzki, Z.A., and Edwards, G.A.:  Dysimmunoglobulinemia in the Absence of Clinical Features of Multiple Myeloma and Macroglobulinemia ,  Amer J Med 42:67-88 ( (Jan) ) 1967.Crossref