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December 1986

Influenza Vaccine and Pneumonia Mortality in a Nursing Home Population

Author Affiliations

From the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (Drs Saah, La Montagne, Blackwelder, and Kaslow); the Jewish Home and Hospital for Aged, New York (Drs Neufeld and Rodstein); the Hackensack (NJ) Medical Center (Dr Gross); and Office of Biologics, the Food and Drug Administration, Bethesda, Md (Dr Quinnan).

Arch Intern Med. 1986;146(12):2353-2357. doi:10.1001/archinte.1986.00360240071013

• The effectiveness of immunization against influenza in elderly persons is uncertain. A retrospective cohort study in a New York City nursing home examined the occurrence of pneumonia and its related mortality over three consecutive influenza seasons (Nov 1 through April 30,1979 to 1980,1980 to 1981, and 1981 to 1982). Nearly one half of approximately 450 residents (mean age, 84 years) accepted immunization each year. The vaccinated and unvaccinated groups were similar. The attack rate of pneumonia did not differ significantly between the vaccinated and unvaccinated groups in any of the three influenza seasons. When influenza was occurring in the community (1979 to 1980 and 1980 to 1981), however, the risk of death from pneumonia in the unvaccinated group was threefold higher than in the vaccinated group (60% vs 18% and 73% vs 25%, respectively). In a year when influenza was specifically sought and not found in the facility (1981

Ailing DW, Blackwelder WC, Stuart-Harris CH:  A study of excess mortality during influenza epidemics in the United States, 1968-1976.  Am J Epidemiol 1981;113:30-43.
Glezen WP, Payne AA, Nelson Snyder D, et al:  Mortality and influenza.  J Infect Dis 1982;146:313-321.Crossref
Glezen WP:  Serious morbidity and mortality associated with influenza epidemics.  Epidemiol Rev 1982;4:25-44.
Barker WH, Mullooly JP:  Pneumonia and influenza deaths during epidemics.  Arch Intern Med 1982;142:85-89.Crossref
 Influenza vaccine 1980-81.  MMWR 1980;29:225-228.
Hall WN, Goodman RA, Noble GR, et al:  An outbreak of influenza B in an elderly population.  J Infect Dis 1981;144:297-302.Crossref
Goodman RA, Orenstein WA, Munro TF, et al:  Impact of influenza A in a nursing home.  JAMA 1982;247:1451-1453.Crossref
Patriarca PA, Weber JA, Parker RA, et al:  Efficacy of influenza vaccine in nursing homes.  JAMA 1985;253:1136-1139.Crossref
Lee ET:  Statistical Methods for Survival Data Analysis . Belmont, Calif, Lifetime Learning Publications, 1980.
Dixon WJ, Brown MB:  BMDP Biomedical Computer Programs, P-Series . Berkeley, Calif, University of California Press, 1977.
Breslow N:  Covariance analysis of censored survival data.  Biometrics 1974;30:89-99.Crossref
Howells CHL, Vesselinova-Jenkins CK, Evans AD:  Influenza vaccination mortality from bronchopneumonia in the elderly.  Lancet 1975;1:381-383.Crossref
Barker WH, Mullooly JP:  Influenza vaccination of elderly persons.  JAMA 1980;244:2547-2549.Crossref