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April 1910


Author Affiliations


From the Clinical Laboratory of the Sheppard and Enoch Pratt Hospital.

Arch Intern Med (Chic). 1910;V(4):374-381. doi:10.1001/archinte.1910.00050260051005

During the course of some studies of metabolism it was desired to bring about a moderate grade of anesthesia in order that a diagnostic lumbar puncture might be made possible, and for this purpose a mixture of scopolamin (hyoscin), hydrobromate and morphin (sulphate) was given subcutaneously a short time before the operations were carried out.1 It is stated2 that morphin and several of its derivatives when given in therapeutic doses will cause no alteration in the respiratory metabolism, while conclusions concerning the protein metabolism are at variance, some observers having found an increase and others a decrease in the intensity. In either case the variation seems to have been quite slight. With atropin and several of its congeners, however, a somewhat more definite result seems to have been obtained. De Stella,3 after long-continued small doses of scopolamin, noted in four experiments on rabbits and dogs that

In order to perform a lumbar puncture for the purpose of diagnosis in these patients it is desirable and generally necessary to administer some sedative medicine to allay the attacks of motor restlessness and irritability to which persons with general paresis are so frequently subject. The effects of the drugs thus administered for diagnostic and therapeutics measures are recorded here in so far as the metabolic functions are concerned.
Von Noorden: Pathologie des Stoffwechsels, ed. 2, 1907, ii, 775.
De Stella: ., 1907, ii, 807.
Barnes:  A Study of the Metabolism of Two Atypical Cases Related to the Dementia Præcox Group ,  Am. Jour. of Insanity , 1909, lxv, 593. ,
Although this last day at first suggests some loss of material, I feel quite certain that all urine voided during the twenty-four hours is here represented. This experiment would no doubt have been of more complete value if continued for at least another day, but this could not be done.
Wait: Experiments on the Effect of Muscular Work on the Digestibility of Food and the Metabolism of Nitrogen, U. S. Dept. of Agric., O. E. S. Bull. 117, 1902, p. 40.
Magnus, R.:  Die stopfende Wirkung des Morphins ,  Arch. f. d. ges. Physiol. , 1908, cxxii, 210.Crossref