[Skip to Content]
[Skip to Content Landing]
Article
July 1910

THE QUANTITATIVE DETERMINATION OF THE CHLORIDS IN THE URINE

Author Affiliations

NEW HAVEN, CONN.

From the Sheffield Laboratory of Physiological Chemistry and the Medical Laboratory of Yale University.

Arch Intern Med (Chic). 1910;VI(1):12-18. doi:10.1001/archinte.1910.00050290017002
Abstract

The methods commonly described for the determination of the chlorids in the urine are, with the exception of those of Mohr and Volhard, either too long and complicated for the busy clinician or too inaccurate for anything approaching scientific work.

The method described by Mohr,1 in which the chlorids are precipitated by a standardized solution of silver nitrate, using potassium chromate as an indicator, is a rapid and convenient process. It uniformly gives too high results,2 however, as the silver also precipitates the uric acid, purin bases, urinary pigments, etc., and therefore is not satisfactory for accurate work in the urine.

The Volhard method3 as modified by Drechsel4 and applied to the urine by Falck and Arnold consists briefly in the precipitation of the chlorids by an excess of a standardized solution of silver nitrate, the removal of the silver chlorid by filtration and

References
1.
Mohr, F.:  Lehrbuch der Titrirmethode , 1856, 11, 13.
2.
Neubauer and Vogel:  Anleitung zur Analyse des Harns , 1898, p. 709.
3.
Volhard, J.:  Ueber eme neue Methode der massanalytischen Bestimmung des Silbers ,  Jour. f. prakt. Chem. , 1874, ix, 217.Crossref
4.
Drechsel, E.:  Zur Volhard'schen Silberbestimmung ,  Jour. f. prakt. Chem. , 1877, xv, 191.
5.
Rosanoff, M. A., and Hill, A. E.:  A Necessary Modification of Volhard's Method for the Determination of Chlorids ,  Jour. Am. Chem. Soc. , 1907, xxix, 269.Crossref
6.
Goodall, H. W.:  An Accurate Method for the Quantitative Determination of Chlorin in Urine ,  Boston Med. and Surg. Jour. , 1909, clx, 304.Crossref
×