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In a study of the literature concerning the urea content of the spinal fluid, we have been struck by the amount of work done on this subject by French clinicians as contrasted with its apparent neglect by German, English and American clinicians.
The normal quantity of urea in the spinal fluid, as indicated from a review of a considerable mass of material in the literature, varies between 0.01 per cent. and 0.05 per cent. Mollard and Froment,1 in 1909, reviewed the literature up to that time and cited the works which follow in brief. Richet, in 1897, gave twenty-five analyses and stated "possibly urea." Deniges and Sabrazés, and Sabrazés and Binaud,2 in 1895, reported two cases of tuberculous meningitis showing 0.015 per cent. and 0.035 per cent, of urea in the spinal fluid. Comba,3 in 1899, reported two cases of acute uremia, in which there was an
SOPER WB, GRANAT S. THE UREA CONTENT OF THE SPINAL FLUID WITH SPECIAL REFERENCE TO ITS DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE: A SERIES OF NINETY-SEVEN CASES. Arch Intern Med (Chic). 1914;XIII(1):131–142. doi:10.1001/archinte.1914.00070070136007
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