[Skip to Content]
[Skip to Content Landing]
Article
February 1914

THE EFFECT OF HEAT ON BLOOD-PRESSURE

Author Affiliations

BOSTON

From the Department of Medicine and the Laboratory of Physiology, Harvard Medical School.

Arch Intern Med (Chic). 1914;XIII(2):287-297. doi:10.1001/archinte.1914.00070080112005
Abstract

In most infectious disease there is a progressive fall in blood-pressure during the course of the infection. This fall has been attributed to a weakness or insufficiency of the circulatory apparatus. In 1899 Romberg, Pässler, Bruhns and Müller1 investigated the cause of this presumed weakness by means of animal experiments. They reached the conclusion that the myocardium was not at fault but that the toxin of the infection caused a grave injury to the vasomotor center in the medulla, and that the low pressure was due entirely to an abeyance of the function of this center. Since that time it has been generally held by clinicians that the height of the blood-pressure in the infectious diseases was a measure of the tone of the vasomotor center, that low readings were evidence of the failure of the center and were an absolute indication for therapeutic procedures which stimulated the center.

References
1.
Romberg, Pässler, Bruhns and Müller: Experimentelle Untersuchungen über die allgemeine Pathologie der Kreislaufstörung bei acuten Infections-krankheiten,  Arch. f. klin. Med. , 1899, lxiv, 652.
2.
Halliburton, W. D. :  Chemical Side of Nervous Activity ,  Croonian Lectures , London, 1901, p. 42.
3.
Marinesco: Quoted by Halliburton.
4.
Lawrence, C. H.: The Effect of Pressure-Lowering Drugs and Therapeutic Measures on the Systolic and Diastolic Pressures in Man,  The Archives Int. Med. , 1912, ix, 409.Crossref
5.
DeZilwa: Quoted by Grützner,  Ergebn. d. Physiol. , 1904, ii, 12.
6.
Stewart, C. C.:  The Cat's Bladder ,  Am. Jour. Physiol. , 1900, iv, 185.
7.
Hodge: Quoted by Donaldson,  The Growth of the Brain , London, 1895, p. 317.
8.
Donaldson, H. H.:  The Growth of the Brain , London, p. 309.
9.
Helmholtz and Von Miram: Quoted by Snyder,  Am. Jour. Physiol. , 1908, xxii, 179.
10.
Porter, W. T., Marks, H. K., and Swift, J. B.:  The Relation of Afferent Impulses to Fatigue of the Vasomotor Center ,  Am. Jour. Physiol. , 1907, xx, 444.
11.
Porter, W. T.:  Relation of Afferent Impulses to the Vasomotor Center ,  Am. Jour. Physiol. , 1910, xxvii, 276.
12.
Henderson, Y.:  A Principle Underlying the Normal Variations in the Volume of the Blood-Stream , Etc.,  Am. Jour. Physiol. , 1909, xxiii, 353.
×