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In the earliest days of the investigation of some of the important soluble ferments, or enzymes, the question of their behavior toward each other came up for study. In the human body we have to consider the action of the salivary, the gastric, the pancreatic and the intestinal ferments, and the behavior of each one of these may be modified not only by the reaction of the medium in which it acts, but also by the presence of others. Since the activity of the salivary diastase is not confined to the mouth, but is continued to the stomach, the effect of the hydrochloric acid and pepsin present has naturally been the subject of frequent studies. Practically, the behavior of the acid alone has real importance, since the ptyalin is so sensitive to the acid that even minute traces are sufficient to render it inert. That pepsin, also, may
LONG JH, MUHLEMAN GW. THE MUTUAL ACTION OF CERTAIN DIGESTIVE FERMENTS. Arch Intern Med (Chic). 1914;XIII(2):314–348. doi:10.1001/archinte.1914.00070080139007
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