[Skip to Content]
[Skip to Content Landing]
Article
May 1914

THE PHYSIOLOGIC DEGENERATION OF THE MESONEPHROS: WITH A CONSIDERATION OF ANTAGONISTIC ACTION OF ORGANS AND OF FUNCTIONAL MUTATION WITH MORPHOLOGICAL PERSISTENCE

Author Affiliations

LONDON, ENGLAND

From the Gordon Pathological Laboratory of Guy's Hospital.

Arch Intern Med (Chic). 1914;XIII(5):770-789. doi:10.1001/archinte.1914.00070110099005
Abstract

I propose to draw attention to certain embryological processes and phenomena which appear to have escaped a more than cursory attention by the pathologist and, if a perusal of the literature and an inquiry among those able to judge lead me to suppose correctly, have received a rather inadequate consideration by anatomists and physiologists. The road, therefore, is difficult to travel, and the observations and considerations which are recorded below will appear necessarily fragmentary and incomplete. Indeed, the difficulty of obtaining suitable material and other more personal obstacles allow me to offer no more than an outline of the matter. That, however, seems warranted by the importance and the unfortunate neglect of the subject. Even in incomplete form it may, nevertheless, obtain the interest and future help of those who by position and experience are able to enlarge on the facts and elaborate the conclusions to be drawn therefrom.

References
1.
The introductory general part was essentially written for those unacquainted with present views of renal development and of the position and structure of the mesonephros; others may turn immediately to the second special part.
2.
Consult Felix, W.:  The Development of the Urogenital Oragns , in  Man- ual of Embryology , edited by F. Keibel and F. P. Mall, Philadelphia and London, J. B. Lippincott Company, 1912.
3.
Felix, W.:  Die Entwicklung des Harnapparats (1904) , in Hertwig's  Handbuch der vergleichenden Entwicklungslehre der Wirbelthiere , Jena, G. Fischer, 1906.
4.
Gaskell, W. H.:  The Origin of Vertebrates , London, etc., Longmans, Green & Co., 1908.
5.
Broman, Ivar:  Normale und abnormale Entwicklung des Menschen , Wiesbaden, Bergmann, 1911.
6.
Bonnet, R.:  Lehrbuch der Entwicklungsgeschichte , Berlin, Paul Parey, 1907.
7.
Braun:  Das Urogenitalsystem der einheimischen Reptilien ,  Arbeiten aus dem zool.-zoot. Institut zu Würzburg , 1877, iv.
8.
Schreiner, K. E.:  Ueber die Entwicklung der Amnioten Niere ,  Ztschr. f. wissensch. Zool. , 1902, lxxi, 1-189.
9.
Von Fürth, O.:  Vergleichende chemische Physiologie der niederen Thiere , Jena, G. Fischer, 1903.
10.
Gegenbaur, C.:  Vergleichende Anatomie der Wirbelthiere , Leipsic, W. Engelmann, 1898.
11.
Mihálkovics, G. Von:  Untersuchungen über die Entwicklung des Harn und Geschlechtsapparats der Amnioten ,  Internat. Monatsschr. f. Anat. u. Histol. , 1885, ii, p. 41 and p. 65.
12.
Winiwarter, H. Von, and Sainmont, E.:  Nouvelles recherches sur l'ovogénèse et l'organogénèse de l'ovaire des mammifères (chat) ,  Arch. de biol. , 1909, xxiv, 373.
13.
I intend to publish at some later day a full, illustrated account of mesonephric degeneration.
14.
Die mikroskopische Untersüchung hat im Frieden des Eies die Existenz höchst dramatischer Vorgänge nachgewiesen, welche ich aus Konzession an eine sehr beliebte Terminologie von zweifelhaften Werthe unter der Bezeichnung des Kampfes der Gewebe züsammenfassen will.
15.
Kermauner:  Das Fehlen beider Keimdrüsen ,  Beitr. z. path. Anat., von Ziegler (now Marchand and Aschoff) , 1912, liv, No. (3) , p. 478.
16.
Wolff, B.:  Ueber foetale Hormone , in  Handbuch der Biochemie von Carl Oppenheim , Ergänzungsband, 1913.
17.
Milne and Peters ( Observations of the Glycolytic Power of the Blood and Tissues in Normal and Diabetic Conditions ,  Jour. Med. Research , 1912, xxvi, 415)
18.
Gaskell: See Footnote 2.
19.
In discussions of the disorders of internal secretion, perhaps insufficient attention has been paid to the importance which the soil may exercise in this connection. It is evident, however, that the effect of an internal secretion depends not only on the function of the gland, but also on the condition of the particular soil which has become receptive to the secretion. It would seem, therefore, that disturbances may arise not only through glandular disorders, but also through developmental or acquired faults of the soil. This mutual relation may play an even greater part when close anatomical and physiological connections existed during embryonic life. Finally, it seems not improbable that internal secretions may be modified on their way by passage through other glands. This opens another opportunity for variations.
20.
Milne and Peters: See Footnote 10.
21.
Potter and Milne:  Bronzed Diabetes ,  Am. Jour. Med. Sc. , 1911, cxliii, 46.
22.
Aschoff, L.:  Zur Morphologie der Nierensekretion ,  Verhandl. d. deutsch. path. Gesellsch. , Jena, G. Fischer, 1912.
23.
I have not touched at all in this communication on any possible differences in this process between male and female and, further, what determines the preservation and subsequent incorporation into the sexual system of certain mesonephric tubules. These problems need special investigation.
×