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Article
June 1914

STUDY XXI: THE IMMEDIATE EFFECT OF REPEATED DOSES OF THEOBROMIN SODIUM SALICYLATE AND THEOCIN ON RENAL FUNCTION IN ACUTE EXPERIMENTAL NEPHRITIS

Author Affiliations
BOSTON
From the Medical Clinic of the Peter Bent Brigham Hospital, Boston, and Laboratory of the Theory and Practice of Physic, Harvard Medical School.
Arch Intern Med (Chic). 1914;XIII(6):945-956. doi:10.1001/archinte.1914.00070120107009
Abstract

Such authorities as Senator,1 Osler,2 Bradford,3 Herrick4 and Forschheimer5 agree that in the treatment of acute nephritis a cautious trial with the use of diuretics may be made with safety, but that such drugs should not be given persistently unless a distinct effect is produced, since large doses or the continued effect of small doses may lead to scanty excretion of urine with retention of urinary products. The experimental evidence for this contention is slight.

Of the diuretics in clinical use, purin derivatives are given most extensively. The exact mechanism by which they produce diuresis is not altogether certain. Munk6 and Schwartz,7 from perfusion experiments on the isolated dog's kidney injected with caffein and allied drugs, found a marked diuresis without any evidence of increased flow of blood through the kidney, and concluded that these substances had a specific effect on renal

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The substance used in these experiments was the brand of theobromin sodium salicylate made by Knoll & Co., and sold under the proprietary name "Diuretin." The theocin sodium acetate was made by Bayer & Co.
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