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Article
August 1914

STUDIES IN THE PATHOLOGY OF THE SPLEEN

Author Affiliations
BALTIMORE
From the Medizinische Klinik (Hofrat Karl von Noorden, Vienna), and the Hunterian Laboratory of Experimental Pathology, Johns Hopkins University, Medical Department.
Arch Intern Med (Chic). 1914;XIV(2):145-167. doi:10.1001/archinte.1914.00070140002001
Abstract

Many diseases of the blood are associated with striking changes in the morphology of the spleen. Often, indeed, the gross change in this organ is the dominating feature of the clinical picture. Much has been written concerning these changes, but as yet little progress has been made in the attempt to correlate changes in the spleen with clinical symptoms.

There is considerable uncertainly about our knowledge of the functions of the spleen. That this organ has important functions, however, can hardly be questioned. There is, for example, considerable evidence to show that the spleen may have a marked influence on hemolysis. It is but a step then to assume that there may exist for the spleen conditions associated with a hyperactivity of some of its functions, let us say the function of influencing hemolysis. To such a condition the term "hypersplenism" may be applied. Conversely, a

References
1.
Faust and Tallquist:  Ueber die Ursachen der Bothriocephalusanaemia ,  Archiv. f. exper. Path. u. Pharmakol. , 1907, lvii, 367.Crossref
2.
Joannovics and Pick:  Beitrag zur Kenntniss der Toluylendiaminvergiftung ,  Ztschr. f. exper. Path. u. Therap. , 1909, xii, 185.Crossref
3.
Joannovics and Pick :  Ueber hämolytisch wirkende freie Fettsämen in der Leber bei akuter gelber Atrophia und Phosphorvergiftung ,  Berl. klin. Wchnschr. , 1910, xx.
4.
Joannovics : Ueber die Auschaltung der Milz aus dem Pfortaderkreislauf, Separat-Abdruck aus den Verhandlung der Deutschem Pathologische Gesellschaft, v.
5.
Pearce, Austin and Evans :  Reactions to Hemolytic Serum at Various Intervals After Splenectomy ,  Jour Exper. Med. , 1912, xvi, 363.Crossref
6.
Pearce, Austin and Eisenbrey:  The Relation of Hemoglobinemia to Hemoglobinuria and Jaundice in Normal and Splenectomized Animals ,  Jour. Exper. Med. , 1912, xvi, 375.Crossref
7.
Pearce, Austin and Musser :  The Changes in the Blood Following Splenectomy, and their Relation to the Production of Hemolytic Jaundice ,  Jour. Exper. Med. , 1912, xvi, 758.Crossref
8.
Karsner and Pearce :  A Study by the Methods of Immunology, of the Increased Resistance of the Red Blood-Corpuscles After Splenectomy ,  Jour. Exper. Med. , 1912, xvi, 769.Crossref
9.
Pearce and Austin :  Change in the Endothelial Cells of the Lymph Nodes and Liver in Splenectomized Animals Receiving Hemolytic Serums ,  Jour. Exper. Med. , 1912, xvi, 780.Crossref
10.
Musser, J. H., Jr.:  An Experimental Study of the Changes in Blood Following Splenectomy ,  The Archives Int. Med. , 1912, ix, 592.Crossref
11.
Musser, J. H., Jr., and Krumbhaar, E. B.:  The Blood-Pictures at Various Periods After Splenectomy ,  Jour. Exper. Med. , 1913, xviii, 487.Crossref
12.
Pearce and Peet :  The Effect of Hemolytic Serum in Splenectomized Dogs ,  Jour. Exper. Med. , 1913, xviii, 494.Crossref
13.
Krumbhaar, E. B., and Musser, J. H., Jr.:  The Relation of the Spleen to Blood Destruction ,  Jour. Exper. Med. , 1913, xviii, 665.Crossref
14.
Eppinger, H.:  Zur Pathologie der Milzfunktion ,  Berl. klin. Wchnschr. , 1913, L, 1509, 1572.
15.
Eppinger, H.:  Zur Pathologie der Milzfunktion ,  München. med. Wchnschr. , 1913, No. (35) , p. 1952.
16.
Pribram:  Hypersplenische Hämophthisen und Stauungsmilz ,  Wien. klin. Wchnschr. , 1913, xxvi, 1607.
17.
McPhedran :  Hemolytic Properties of Fatty Acids and Their Relation to the Causation of Toxic Hemolysis and Pernicious Anemia ,  Jour. Exper. Med. , 1913, xviii, 527.Crossref
18.
Lamar:  Chemico-Immunological Studies in Localized Infections ,  Jour. Exper. Med. , 1911, xiv, 256.Crossref
19.
Hermann and Neumann:  Uber der Lipoidgehalt der Blutes normales und schwangerer Frauen sowie neugeborener Kinder ,  Biochem. Ztschr. , 1912, No. (43) , p. 47.
20.
Abderhalden:  Handbuch der Biochemie Arbeits Methoden , 19, (ii) , 208.
21.
Von Decastello :  Splenectomie bei pernizioser Anämie ,  Wien. klin. Wchnschr. , 1913, xxvi, 951.
22.
Pollitzer :  Ein Fall von Splenomegalia hemolytica ,  Wien. klin. Wchnschr. , 1913, xxvi, 952.
23.
Klemperer and Hirschfeld :  Milzexstirpation bei pernizioser Anämie ,  Therap. d. Gegenw. , 1913, No. (19) .
24.
Nidd:  Banti's Disease Cured by Splenectomy ,  Proc. Roy. Soc. of Med. , 1913, vi, Surg. Sect., p. 225.
25.
Giffin :  Clinical Observations Concerning Twenty-Seven Cases of Splenectomy ,  Am. Jour. Med. Sc. , 1913, cxvl, 781.Crossref
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